Research Papers/Topics in Pharmaceutics

Evaluation of Phyto-Chemical and Medicinal Properties of Cannabis Sativa Linn. (Family Moraceae).

Abstract This work studied the various delivery systems (oral and parental formulations) of crude Cannabis. The stability, pharmacological and toxicological profiles of Cannabis resin in the formulations was also studied. Dried powdered leaves of Cannabis sativa L. were extracted with chloroform, the extract was concentrated to obtain an oil-based tar (resin) and its phytochemical composition determined. The Cannabis crude resin was formulated as syrup, capsule and suppository dosage forms. ...

Solid Dispersions Based on Peg 4000, Soluplus and their Hybrids for Enhanced Delivery of Glimepiride

ABSTRACT The present study investigates the possibility of enhancing the solubility, and hence the bioavailability of poorly water soluble glimepiride via formation of polyethylene glycolpolyvinyl caprolactam - polyvinyl acetate grafted copolymer (Soluplus®) and PEG 4000 based solid dispersions by solvent evaporation technique.Different batches of glimepiride solid dispersions (SD) were prepared using solvent evaporation method with Soluplus® and PEG 4000 as polymer matrix at different rat...

Evaluation of N- Hydroxymethyl Chlorphensin Carbamate and Ethionamide as Potential Prodrugs

ABSTRACT Chlorphensin carbamate is a centrally acting muscle relaxant, insoluble in water, readily absorbed from the gastro-inteatinal tract, when administered orally and highly metabolished. The mechanism of action is by depressing spinal polysynaptic reflexes. Neuronal conduction, neuromuscular transmission and muscle excitability are not depressed except after nearly lethal doses. This action led to its characterisation as inter-neuronal blocking agent and therefore used to relief symptoma...

Characterisation and Application of Grewia Gum in Tabletting

CONTENTS Page Title page ... . . . .-. I. Certification ..- ... . . . ... Dedication ... ... ..I ... Ack nowledgemen t ... -.. . . Abstract ... . ... I.. Contents ... -.. ... ..* CHAPTER 1 INTRODUCTION . . . . 0 0 1.1 Plant Gums -.. .-. ... 1.2 Sources of Plant Gums . . . ... 1- 3 Classification of Plant Gums *.- 1.4 Extraction and purification of Plant Gums 1.5 Cmposition and Structure of Plant Gums 1.6 Analysis of Plant ems .. . ..- 1.6.1 Qualitative Analysis ... .-. 1.7 Physic-chemical Pro...

Sustained Release Solid Lipid Nanoparticles Formulation of Lumefantrine and Ciprofloxacin

Title Page --- --- --- --- --- --- --- --- --- --- i Certification --- --- --- --- --- --- --- --- --- --- ii Dedication --- --- --- --- --- --- --- --- --- --- --- iii Acknowledgment --- --- --- --- --- --- --- --- --- --- iv Table of contents --- --- --- --- --- --- --- --- --- --- vi Abstract --- --- --- --- --- --- --- --- --- --- --- xii List of tables--- --- --- --- --- --- --- --- --- --- xvii List of figures--- --- --- --- --- --- --- --- --- --- xviii CHAPTER ONE: INTRODUCTION --- --...

Solid Dispersions Based on Peg 4000, Soluplus and Their Hybrids for Enhanced Delivery of Glimepiride

ABSTRACT The present study investigates the possibility of enhancing the solubility, and hence the bioavailability of poorly water soluble glimepiride via formation of polyethylene glycolpolyvinyl caprolactam - polyvinyl acetate grafted copolymer (Soluplus®) and PEG 4000 based solid dispersions by solvent evaporation technique.Different batches of glimepiride solid dispersions (SD) were prepared using solvent evaporation method with Soluplus® and PEG 4000 as polymer matrix at different rati...

Phytochemical and Antimicrobial Properties of the Stem Bark of Detarium Microcarpum (Case Alpiniaceae)

TABLE OF CONTENTS TITLE PAGE ... ... ... ... ... ... ... CERTIFICATION ... ... ... ... ... ... & DEDICATION ... ... ... ... ... ... ACKNOWLEDGEMENT ... .... ... ... ... ABSTRACT ... .... ... ... ... ... ... TABLE OF CONTENTS ... ... ... ... ... CHAPTER ONE INTRODUCTION 1.1 Aims of study ... .+. ,.. ... 1.2 Botanic Profile and Functional Properties of Deltrrrtin~ Micr-octrrprrm 1.3 Microorganisnl arid Diseases.. . ... ... ... ... . ,. 1.4 Phytochemicals ... ... ... ... ... ... ... ... 1.5 Anti...

Bioactivity-Guided Studies on the Crude Extract and fractions of Hibiscus Asper Hook F. (Malvaceae) Leaf

ABSTRACT The antibacterial and anti-inflammatory activities of the leaf extract of Hibiscus asper Hook F. (Malvaceae) were investigated. Solvent extraction of the leaves yielded the crude methanol extract (CME), while solvent-guided fractionation of CME yielded a n-hexane fraction (HF), chloroform fraction (CF), ethyl acetate fraction (EF), acetone fraction (AF), butanol fraction (BF), methanol fraction (MF) and water fraction (WF). TheCME and the solvent fractions were subjected to phytochem...

Assessment Of The Pharmaceutical Manufacturing Industry In Kenya To Forecast Local Production Sufficiency

ABSTRACT The World Health Organization’s global strategy on public health aims to support Member States to improve access to essential medicines. The desire of Kenya Government to implement this is expressed by formulation of Kenya National Pharmaceutical Policy (2010) which encourages local production of essential medicines for self-sufficiency. The pharmaceutical manufacturing industry in Kenya is engaged in production of various types of dosage forms but its capacity and capability to p...

Pharmacological Characterization Of The Antiasthmatic Constituent Of The Leaves Of Asystasia Gangetica (L.) Anderson (ACANTHACEAE).

Abstract Asthma Is Currently A Worldwide Problem, With Increasing Prevalence In BothR Children And Adults; A Prevalence Rate Of 5 - 10% Has Been Reported For Nigeria. The Pathophysiological Features Of The Disease Are Bronchoconstriction, Airway Hyperresponsiveness And Chronic Inflammation. Drugs Used In The Management Include Bronchodilators Which Are Short-Term Relievers And Anti-Inflammatory Drugs Which Are Long-Term Controllers. Despite The Availability Of Oral And Inhaled Medications,...

Incidence, Molecular Characterization And Sensitivity To Buchholzia Coriacea Leaf Extract Of Methicillin Resistant Staphylococcus Aureus Nasal Isolates From Tertiary Institution Students In D

ABSTRACT This study investigated the incidence, molecular characters and sensitivity to Buchholzia coriacea leaf extract, of methicillin-resistant Staphylococcus aureus (MRSA) nasal isolates from tertiary institution students in Delta State. Nasal swabs were collected with sterile swab sticks from nine hundred (900) apparently healthy students in the study areas and cultured on mannitol salt agar. The bacterial isolates (S. aureus) were Gram-stained, and the Gram positive isolates subjected...

Solid Dispersions Based On Peg 4000, Soluplus® And Their Hybrids For Enhanced Delivery Of Glimepiride

ABSTRACT The present study investigates the possibility of enhancing the solubility, and hence the bioavailability of poorly water soluble glimepiride via formation of polyethylene glycolpolyvinyl caprolactam - polyvinyl acetate grafted copolymer (Soluplus® ) and PEG 4000 based solid dispersions by solvent evaporation technique.Different batches of glimepiride solid dispersions (SD) were prepared using solvent evaporation method with Soluplus® and PEG 4000 as polymer matrix at different ra...

Analysis Of Pesticide Residue In Maize And Beans Types In Lagos Markets

ABSTRACT Pesticides used in agriculture for the control of various pests often leave residues in foodstuffs and these have been shown to pose health hazards, Analysis of pesticide residues in food is one way to determine the level of human exposure to these chemicals and hence their potential human health hazards. Maize (Zea mays L.) and beans (Phaseolus vulgaris L.) samples purchased from different markets in Lagos State were analyzed for residues of organochlorine, organophosphate and carb...

The Physicochemical Properties, Biopharmaceutics And Chromatographic Quantification Of Atovaquone, In Vitro And In Vivo

ABSTRACT The purpose of this study was to develop a reversed-phase chromatographic method for the quantification of atovaquone, with a view to establish the disposition of atovaquone in selected Nigerians, thereby validating the method developed. However, the parameters involved in the HPLC method developed, included the use of an appropriate internal standard, pyrimethamine. In the developmental phase of method development, the following parameters were established an appropriate internal st...

Analysis Of Pesticide Residues In Maize And Beans Types In Lagos Markets

ABSTRACT Pesticides used in agriculture for the control of various pests often leave residues in foodstuffs and these have been shown to pose health hazards. Analysis of pesticide residues in food is one way to determine the level of human exposure to these chemicals and hence their potential human health hazards. Maize (Zea mays L.) and beans (Phaseolus vulgaris L.) samples purchased from different markets in Lagos State were analyzed for residues of organochlorine, organophosphate and carba...


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