Abstract: Many microorganisms have the potential to cause diseases for which the human body is prone. The discovery of antibiotics has, however, provided important tools to combat bacterial diseases. But due to the indiscriminate use of commercial antimicrobial drugs in the treatment of infectious diseases multiple drug resistance has developed among some pathogens. This creates a need for searching new effective and safe antimicrobial therapeutic agents. The aim of this study was to test th...
Abstract: Phytochemicals are important as protective and disease fighting compounds. The guava (Psidium guajava L.) is a phytotherapic plant used in folk medicine. It is believed to have active components that help to treat and manage various infectious diseases. The present study was carried out to screen and quantify the major phytochemicals and to evaluate antibacterial activities of guava leaf and bark extracts. Extraction was done by maceration using ethanol solvent. Qualitative analysi...
Abstract: Plants have been used for generations as source of medicine in the treatment of a variety of human illnesses. In Ethiopia, many plants are used for this purpose by traditional healers without any scientific justification for their therapeutic values. Thus, this study was aimed atassessing the antibacterial activities of crude extracts obtained from different parts of Calotropis procera and Vernonia amygdalina against Escherichia coli, Staphylococcus aureus, and Pseudomonas aerugino...
Abstract: Plants possess a wide variety of secondary metabolites which have been found to exhibit antimicrobial, antioxidant and antitumor activities. In Ethiopia, a number of plant species are traditionally used for the treatment of many diseases. Among these, Croton macrostachyus and Justicia schimperiana, which are abundantly available in many areas of the Country, are widely known for their traditional medicinal values. Therefore, this study was conducted with the objective of analyzing ...
Abstract: Eucalyptus camaldulensis and E. tetragona are the species of genus Eucalyptus in Ethiopia known for medicinal values of its essential oils. The essential oil composition of these species may vary due to genetic difference. In this study, essential oil composition and antibacterial activities of the leaves of E. camaldulensis and E. tetragona leaf essential oils were analyzed. The oil was extracted by steam distillation by using Clevenger apparatus and their compositions were analyz...
Abstract: Plants have been used for generations as source of medicine in the treatment of human and livestock ailments. Ethiopia is also well recognized for higher diversity and uses of medicinal plants in the treatments of diversified human and livestock diseases. Osyris quadripartita and Toddalia asiatica were reported to possess different phenolic compounds claimed to have potential antimicrobial inhibitory effects. Therefore, the objectives of this study were to assess the phytochemical ...
Abstract: Plant materials continue to play a major role in the primary health care as therapeutic remedies in many developing countries. Three medicinal plants: Moringa oleifera, Azadirachta indica, and Lepidium sativum which were traditionally believed to have medicinal values for the treatment of various infectious diseases were investigated for their antibacterial activities against Staphylococcus aureus, Salmonella Typhi, streptococcus agalactiae and Shigella boydii. Two solvent types (m...
Abstract: ommon mullein, also known as Wooly Mullein (Verbascum thapsus L., Scrophulariaceae) has been used as a medicinal herb since ancient times. The aim of the present study was to investigate qualitative screening of major phytochemicals and antimicrobial activity of common mullein (Verbascum thapsus L.) root, leaf and fruit methanolic extracts. The qualitative analyses of major phytochemicals were tested for tannins, phlobatannins, saponins, flavonoids, steroids, termenoids and alkaloi...
Abstract: The study of indigenous knowledge on utilization of native plants as source of medicine is important to conserve useful plants and preserve indigenous knowledge for next generation. This study documents indigenous medicinal plant utilization and factors contributing to the dwindling of native plants and indigenous knowledge. The study was undertaken in Kurfa Chele Woreda, East Hararghe Zone Oromia Region, and Ethiopia. Fifty respondents (10 key informants (traditional healers) and ...
Abstract: Ethiopia has rich flora with different plant species having use in health care system based on local indigenous knowledge. However, the documented ethnomedicinal plants information was lacking in Gedeb Hasasa district. Hence, the aim of this study was to identify, document and evaluate the antifungal activities of extracts of some selected plant species prescribed by traditional healers in study area.A total of 60 (48 males and 12 females) informants were selected as recommended by...
Abstract: Marula (Sclerocarya birrea (A. Rich.)Hochst.)is often referred to as the “tree of life “since its leaves, stem barks, roots, and fruits are used as food and traditional medicine. The present study is undertaken to investigate antioxidant and antimicrobial activities of the aqueous and methanolic extracts of S. birrea leaf and seed extracts. Qualitative analysis of major secondary metabolites including alkaloids, flavonoids, saponins, steroids, tannins and terpenoids of the S. b...
Abstract: In the different parts of Ethiopia Carica papaya is widely used for nutritional purpose and traditionally used to treat disease. The aim of this study was to quantitatively analyze the major secondary compounds of C. papaya and to evaluate antimicrobial properties of its leaf extract against S. aureus and E. coli. The leaf of C. papaya was shade dried, ground to powders, and extracted by using distilled water and ethanol. Total phenolic, alkaloids and terpenoids in the resulting ex...
Abstract: Antibiotic resistance has been a growing worldwide public health issue. The World Health Organization (WHO) has stated that the search for new antibiotics is slow, while antibiotic resistance is growing. WHO has also declared that antibiotic resistance is one of the top 10 global public health threats facing humanity in the 21st century. Therefore, this review discusses the potential of metal-based drugs as antibacterial agents from the period of the early 2000s to date. The review...
Abstract: The potential antimicrobial properties of a tridentate polypyridyl ligand 4-butoxy-N,N-bis(pyridin-2-ylmethyl)aniline (BUT) 1 and its corresponding mixed ligand ruthenium complexes were investigated on drug-resistant and non-drug-resistant bacterial species. The ligand and its complexes were synthesized and successfully characterized by 1H NMR, UV/Vis, and FTIR spectra; ESI-MS; and magnetic susceptibility. Electronic spectra and magnetic susceptibility of these Ru(II)/(III) complex...
Abstract: Albizia anthelmintica is a medicinal plant belonging to the Fabaceae family. It is widely used by smallholder farmers and pastoralists to treat internal parasites in their livestock.This study aimed to determine the antibacterial and antioxidant potential of A. anthelmintica on pathogenic veterinary isolates. 100% hexane (He100), 100% chloroform (Ch100), 100% ethanol (E100), and 70% ethanol (E70) extracts of the roots and barks of A. anthelmintica were tested against four bacterial...