Research Papers/Topics in Pharmacology

Protective Role of Aqueous Leaf Extract of Vernonia Amygdalina Del. (Asteraceae) and Ocimum Gratissimum Linn (Lamiaceae) in Cyclophosphamide Induced Urotoxicity and Myelosuppression

ABSTRACT  Cyclophosphamide (CP) is one of the most potent and widely used alkylating anticancer agents. Urotoxicity and myelosuppression is known as the most prevailing dose-limiting toxicity associated with CP. In the present study, the protective potential of Vernonia amygdalina and Ocimum gratissimum aqueous leaf extracts in CP-induced urotoxicity and myelosupression were evaluated using biochemical and histopathological approaches. Sodium -2-macarptoethane sulfonate (MESNA) was used as a...

Evaluation of the Subacute and Delayed Toxicity of Artemether-Lumefantrine Combination in Rats

ABSTRACT  Despite the reported rapid increase in demand for artemisinin and its derivatives, there is little independent collaboration of the toxicity patterns of artemether-lumefantrine combination besides those documented by the manufacturer in its application for approval. It is however, pertinent to conduct an independent evaluation of the subacute and delayed toxicity of artemether-lumefantrine combination (ALC). In this study, rats in groups I-VI were administered varying concentration...

Serum Profiles Of Pro-Inflammatory Cytokines And Some Other Biomarkers Of Inflammation In Nigerian Tuberculosis Patients Undergoing Standard Chemotherapy At Enugu.

Introduction:Tuberculosis (TB) is a communicable disease that has afflicted man for centuries. It is one of the commonest causes of death from infectious diseases in the world. Nigeria is ranked among the 22 countries with the highest TB burden in the world. The discovery of host or pathogen specific biomarkers of TB for diagnosis, treatment, and prognosis has of recent become top research priority globally. The pathogenesis of TB involves cell-mediated immune response against Mycobacterium t...

Evaluation of Hypoglycaemic Effect And Phytochemical Constituents of Methanol Extract of Vernonia Amygdalina Del Fam. (ASTERACEAE)

ABSTRACT Leaf of Vernonia amygdalina has been shown to have hypoglycemic activity. This may be as a result of the presence of secondary metabolites as its constituents. The major secondary metabolites present in the leaf are tannins, carbohydrates, reducing sugars, glycosides, steroids and proteins. This work was designed to identify these secondary metabolites responsible for this activity, test the lethality of the constituents and then determine the best solvent for extraction. A 1 kg cru...

Evaluation of The Antiplasmodial Activity of Methanol Leaf Extract And Fractions of Landolphai Owariesis P. Beauv (APOCYNACEAE) in Mice

ABSTRACT  Landolphia owariensis P. Beauv (Apocynaceae) is a woody liane commonly used in Africa for the treatment of gonorrhea, worm infestation and malaria. The methanol leaf extract (ME) of L. owariensis was obtained by cold maceration and then fractionated into nhexane (nHF), ethylacetate (EF) and methanol (MF) fractions. The methanol extract and fractions were tested against chloroquine-sensitive Plasmodium berghei berghei in early, established and repository models of infection using Pe...

NEUTRALIZATION OF THE LETHAL EFFECT OF BITIS ARIETANS VENOMBY EUPHORBIA COTINIFOLIA LEAF EXTRACT

TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE---------i DECLARATION--------ii CERTIFICATION--------iii DEDICATION--------iv ACKNOWLEDGEMENT-------v TABLE OF CONTENT-------vi LIST OF TABLES--------ix LIST OF FIGURES-------ix ABSTRACT---------x CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW 1.1 TRADITIONAL MEDICINE-------1 1.2 MODERN MEDICINE--------4 1.2.1 The Role of Plants in Drug Development -----4 1.3 DESCRIPTION OF THE STUDY PLANT   - -----5 1.3.1 Scientific Classification and Folkloric U...

The anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models

ABSTRACT Objectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models . Methods:  The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided into five groups of four mice each. Group 1 received distilled water and served as negative control; group 2 received 100mg/kg of ECS; group 3 receiv...

Anti-ulcerogenic Effects of Chloroform extract of Chasmanthera dependens on Indomethacin and Aspirin-iduced Ulcer in Rats

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortality rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmanthera dependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided into two broad groups of twenty five rats each for aspirin and indomethacin models respectively. For each model, twenty five adult rats divided into five groups of four rats each were used for ulcer s...

Anti-inflammatory and analgesic activities of Alafia barteri and it’s possible mechanisms of action.

ABSTACT The pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated. The analgesic effect of the metanolic root extract of Alafia barteri (100, 200 and 400mg/kg) was evaluated in mice using Acetic acid induced writhing, Formalin induc...

EFFECT OF AQEUOUS EXTRACT OF Rauwola vomitoria ROOT EXTRACT ON ISOLATED RABBIT INTESTINE

Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with adrenaline.seven healthy adult rabbit bred in the animal house of college of basic medical science delta state university,abrake were alowed to aclim...

EFFECT OF COMBINED TREATMENT WITH CHLOROQUINE AND ARTESUNATE ON WHITE BLOOD CELL COUNT OF PLASOMDIUM BERGHEI INFECTED ALBINO MICE

ABSTRACT Malaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and observe effect of combined treatment of chloroquine and artesunate on white blood cell count of P. berghei infected albino mice.    A total of 15 ...