Research Papers/Topics in Pharmacology

The anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models

ABSTRACTObjectives: to explore the anxiolytic activity of ethanolic leaf extract of culcasian scadens in experimental animal models .Methods:  The anxiolytic activity was examined by using the elevated plus maze (EPM) and open field test (OFT), hole board test and light and dark box exploration test. Twenty Swiss albino male mice were divided into five groups of four mice each. Group 1 received distilled water and served as negative control; group 2 received 100mg/kg of ECS; group 3 received...

Anti-ulcerogenic Effects of Chloroform extract of Chasmanthera dependens on Indomethacin and Aspirin-iduced Ulcer in Rats

Peptic ulcer is one of the leading causes of gastrointestinal surgery with high morbidity and mortal￾ity rates. This study assessed the anti-ulcerogenic effect of the chloroform extract of Chasmantheradependens on indomethacin and aspirin-induced ulcer in rats. Fifty (50) adult rats were divided intotwo broad groups of twenty five rats each for aspirin and indomethacin models respectively. Foreach model, twenty five adult rats divided into five groups of four rats each were used for ulcerst...

Anti-inflammatory and analgesic activities of Alafia barteri and it’s possible mechanisms of action.

ABSTACTThe pharmacological effects of the metanolic root extract of the plant Alafia barteri Oliv. used commonly in West and Central Africa, from Guinea Bissau east to Cameroon and south to Congo, including Nigeria for the treatment of various diseases (including malaria, arthritis, eye infection an inflammation) was evaluated.The analgesic effect of the metanolic root extract of Alafia barteri (100, 200 and 400mg/kg) was evaluated in mice using Acetic acid induced writhing, Formalin induced ...

EFFECT OF AQEUOUS EXTRACT OF Rauwola vomitoria ROOT EXTRACT ON ISOLATED RABBIT INTESTINE

Rauwolfia vomitoria is a natural medicinal herb which has been used over the years for the treatment of hypertension and mental disorders. This is to investigate the inhibitory effect of RAUWOLFIA VOMITORIA aqueous root extract on invitro isolated rabbit intestine precontracted with Acetylcholine. The effect of the root extract was compared with adrenaline.seven healthy adult rabbit bred in the animal house of college of basic medical science delta state university,abrake were alowed to aclim...

EFFECT OF COMBINED TREATMENT WITH CHLOROQUINE AND ARTESUNATE ON WHITE BLOOD CELL COUNT OF PLASOMDIUM BERGHEI INFECTED ALBINO MICE

ABSTRACTMalaria is an enormous public health problem worldwide and kills one to two million people every year, mostly children residing in Africa . And the aim of this study is to determine the impact of combined treatment with Artesunate and Chloroquine on the white blood cell count of plasmodium berghei infected albino mice. And to compare and observe effect of combined treatment of chloroquine and artesunate on white blood cell count of P. berghei infected albino mice.   A total ...