ABSTRACT Mushroom cuisines are global delicacies and have been used for decades, not only as food, but mostly for the health benefits which are claimed or scientifically proven. The present study explored the immunomodulatory activities of the hot aqueous extract of a local oyster mushroom, Pleurotustuberregium (Fr.) Singer (Pleurotaceae) (PT) and its β–D-Glucan-Rich Polysaccharide fraction (BGP).The effects of the aqueous extract (PT) and the β–D-Glucan-Rich Polysaccharide fraction (B...
ABSTRACT The immunomodulatory properties of methanol extract and fractions of Hoslundia opposita leaf on Delayed-Type Hypersensitivity (DTH), primary and secondary humoral response and in vivo leucocyte mobilization were evaluated. Acute toxicity test of crude extract and phytochemistry study was carried out. The methanol extract (ME) at 200, 400 and 800 mg/kg body weight produced significant (P
ABSTRACT The anti-ulcer and other gastrointestinal effects of the methanol extract and fractions of Cucumis metuliferus were investigated in rats and mice. Ethyl acetate (EAFCM), butanol (BFCM) and water (WFCM) fractions obtained from the methanol extract of Cucumis metuliferus (MECM) were screened for anti-ulcer activity. The anti-ulcer effect was investigated on gastric ulcers induced by absolute ethanol, hypothermic-restraint stress and indomethacin in rats. The median lethal dose (LD50)...
ABSTRACT Gastrointestinal nematode parasitism is a global problem in both sub-tropical and tropical countries. Due to frequent administration of chemical anthelmintics the gastrointestinal nematodes have developed resistance hence giving rise to the search of alternative anthelmintics. This study was carried out to evaluate anthelmintic effects of Tithonia diversifolia in Mbinga district, Ruvuma region, Tanzania. The study specifically dealt with evaluation of the efficacy of T. diversifolia...
ABSTRACT Peptic ulcer disease (PUD) is a sore in the lining of the stomach or duodenal mucosa. The search for an ideal antiulcer drug continues and has also been extended to medicinal plants. Bridelia ferruginea Benth (Euphorbiaceae) is a plant used in traditional medical practice in South West Nigeria. This study was aimed at evaluating the antiulcer activity and mechanisms of the extract of the stem bark and to isolate the bioactive constituents responsible for the antiulcer activity. Met...
ABSTRACT Terminalia superba Engl. & Diels (Combretaceae), is a member of the genus Terminalia that comprises around 100 species distributed in tropical regions of the world. In Africa it is found along the coast of west and central Africa. It has different uses in traditional medicine such as antimalarial, anti-diabetic, anti-fungal, and anti-hypertensive in the areas where it is found. Most of these uses are yet to be scientifically investigated. The powdered stem bark of Terminalia superba...
ABSTRACT Introduction: Prostate cancer is a major disease that affects adult males. The high cost of current drugs in use, treatment failure/drug resistance as well as toxic side effects warrants the development of more effective, less toxic and affordable anti-prostate cancer drugs. The aim of the study was to investigate the anti-prostate cancer properties of selected Ghanaian medicinal plants used for the management of prostate cancer. Method: The leaves, fruit and seeds of selected plant...