Research Papers/Topics in Physiology

Pregnancy- Induced Changes In Some Ventilatory Indices In Enugu, South East Nigeria

ABSTRACT Pregnancy is essentially a physiological process, which involves a great number of physiological changes, affecting virtually all the organ systems in the body. Literature is sparse on the changes in ventilatory function during pregnancy in our locality. The objective of this study is to establish the value of Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), FEV1/FVC ratio and Peak Expiratory Flow Rate (PEFR) during pregnancy. The study is a descriptive cro...

Impact Of Hibiscus Sabdariffa Calyx Aqueous Extract Consumption By Pregnant And Lactating Spraguedawley Rats On Pregnancy Outcome And Postnatal Development

ABSTRACT Extracts of Hibiscus sabdariffa (HS) are widely believed in folk medicine to be effective in the treatment of a variety of ailments. Aqueous extract of HS has been reported to decrease fluid and food consumption and weight gain in non-pregnant rats through mechanisms not yet fully understood. Thus when aqueous extract of HS is administered to pregnant and lactating animals, it may lead to decreased food consumption and consequently, malnutrition in these animals. Maternal malnutriti...

Market Integration And Pricing Efficiency Of Soyabeans In Benue And Enugu States, Nigeria

ABSTRACT The study analysed market integration and pricing efficiency of soyabeans in Benue and Enugu States, Nigeria. Low household demand for soyabeans makes its production and marketing less popular amongst farmers and marketers which leads to marketing inefficiency. A two-stage sampling technique was used to select 207 respondents. Secondary data comprising monthly retail prices (urban and rural) of soyabeans from 1999 to 2013 was also collected BNARDA and ENADEP. Descriptive statistics, ...

Experiences Of Children Who Have Gone Through The Foster Care Program In Zimbabwe.

ABSTRACT The research examined the experiences of children who have gone through the foster care program in Zimbabwe. Children coming into foster care would have been take away from their parents may be facing emotional, psychological and behavioural problems due to the turmoil, abuse and negligence they may have experienced as such it is critical to emphasise the healing aspect of foster care. There are certain challenges from the system which need to be addressed. This research was guided ...

Changes In Selected Biochemical Parameters In Thermal Burns Patients At The Korle Bu Teaching Hospital

ABSTRACT  Background: Thermal burns injuries are associated with changes in biochemical parameters which require specialized care. Burn shock is the first consequence of deep and extensive burns that constitutes the main cause of mortality if local and systemic treatments are not correct and timely. Changes in the biochemical parameters are attributed to the hypermetabolic state, arising mainly from increases in adrenaline release, hemolysis, sepsis, loss of fluid and electrolytes that requi...

The Biochemical Effects if Cussonia Arborea Root Bark Extract in Alloxan -Induced Diabetic Rats

ABSTRACT Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. It is a growing public health concern worldwide affecting humans and animals. Synthetic drugs available for the treatment of the ailment have serious side effects, complicated mode of intake and are costly. Literature search revealed that Cussonia arborea is used folklorically in the management of Diabetes mellitus....

The Toxic Effect Of Six Commonly Occurring Plants In .Nigerian Pastures

ABSTRACT The toxicology of six suspected poisonous plants Leucaena leucocephala Benth, Tribulus terrestris Linn Eugenia uniflora Linn, Dichapetalum madagascasience Poir, Lantana camara Linn, and Solanum torvum Benth); were evaluated in Sprague Dawley rats weighing between 200-300 grams. Two of these plants, Lantana camara and ~. madagascasience were re-evaluated in West African dwarf goats. Spectrophotometric and titrimetric methods were also used to determine some inorganic and metallic cont...

An evaluation of serum leptin dynamics in Preeclampsia at the Korle-Bu Teaching Hospital

ABSTRACT Background: Preeclampsia is a peculiar human pregnancy condition with heightened immune response, oxidative stress, hypoxia and reduced angiogenesis. These features of preeclampsia which are influenced by leptin which causes endothelial dysfunction; the main pathology of this condition. Hypertension, which is a diagnostic marker of preeclampsia, is also associated with increased leptin level. This implicates leptin in preeclampsia pathogenesis. Data from Caucasians and Asians show hi...

Serum Levels Of Angiogenic And Antiangiogenic Factors In Ghanaian Women Diagnosed With Preeclampsia And Its Relation To Fetal Outcomes

ABSTRACT Background: Pregnancies complicated by pre-eclampsia are associated with a high rate of maternal and fetal morbidity and mortality. The only effective treatment of pre-eclampsia is premature delivery of the baby and the placenta which can result in neonatal complications. Antiangiogenic and angiogenic factors have been implicated in the pathophysiology of preeclampsia resulting in of placental ischemia with subsequent maternal endothelial cell dysfunction and fetal complications. Gen...

Metabolic Syndrome In Acute Stroke Survivors At Korle-Bu Teaching Hospital

ABSTRACT Background: The presence of metabolic syndrome (MetS) has been associated with an increased risk of stroke. The indicators of MetS that predispose individuals to stroke still persist after stroke. There is insufficient information on MetS in acute ischaemic and haemorrhagic stroke survivors at Korle-Bu Teaching Hospital. Aim: This study assessed metabolic syndrome in acute stroke survivors at Korle-Bu Teaching Hospital. Method: This was a cross-sectional study involving patients at t...

Association Between Arterial Stiffness And Circulating Adipokines In Patients With Systemic Lupus Erythematosus In Ghana

ABSTRACT Background: Cardiovascular complication accounts for greater number of deaths that occur in lupus patients who have chronic inflammation. However, arterial stiffness is used to predict diseases of the cardiovascular system, characterized by persistent inflammation which affects adipose tissues, dysregulation of adipokines and hyperinsulinemia, tend to quicken hardening of arteries in patients with systemic lupus erythematosus (SLE). Aim: This study investigated association existing b...

Baseline Serum And Urine Osmolality And Factors That Affect It In Steady State Sickle Cell Disease Patients

ABSTRACT It is over a century since the discovery of Sickle Cell Disease (SCD) and since then, a lot more is still being discovered about the pathophysiology of the disease. Notable amongst the various factors that affect the disease’s pathophysiology and management is red cell dehydration. Factors that affect cellular dehydration and serum osmolality in SCD patients are not very clearly understood. An objective method among of assessing SCD patient’s hydration status is by measuring the ...

Ageing in an Elderly Ghanaian Population: A Cross Sectional Study of Physiological Parameters, FOXO3A Genetic Variability And Oxidative Stress

ABSTRACT  Brief background Worldwide, the population of the elderly has tripled in the last century. Projections indicate that the global population of persons aged 60 years and over, which was 11% in 2000 will reach 22% by 2050. Ageing is a gradual process with various determinants many of which are modifiable. Functional systemic changes, together with the effect of the environment, nutrition, lifestyle and genome of a person may insidiously lead to the development of chronic age-associate...


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