Research Papers/Topics in Biochemistry

Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats

Objective: To determine the noxious attribute of methanol extract of Nigeria bee propolis at 300 and 600 mg/kg body weight in rats.Methods: Healthy Wistar rats were indiscriminately assigned into three groups (A-C) of five rats each. The control rats (Group A) were orally given 0.5 mL of dimethyl sulfoxide daily for 21 days while rats in Groups B and C were administered the same 0.5 mL dimethyl sulfoxide containing 300 and 600 mg/kg body weight methanol extract of bee propolis respectivel...

African natural products with potential antioxidants and hepatoprotectives properties: a review

Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome ...

Human Genetic Markers and Structural Prediction of Plasmodium falciparum Multidrug Resistance Gene (pfmdr1) for Ligand Binding in Pregnant Women

Te study aims to determine the association of malaria infection with ABO blood groups and genotype and also to detect pointmutations at positions 86, 184, 1034, and 1042 of the Plasmodium falciparum multidrug resistance gene (pfmdr1) in blood samplescollected from pregnant women attending General Hospital Minna. Out of 250 pregnant women screened, 39 (15.60%) had malariainfection. Prevalence was higher in women, during the third trimester (46.15%), genotype AA (64.10%), and O blood group (53....

POLYETHYLENE GLYCOL – MODIFIED NANOCARRIER ENCAPSULATION OF DIMINAZENE ACETURATE IMPROVED HAEMATOBIOCHEMICAL RECOVERY IN TRYPANOSOMA BRUCEI BRUCEI INFECTED RATS

AbstractThe enhanced safe drug delivery properties of polyethylene glycol (PEG) – modified Diaminazene aceturate nanocomposite against Trypanosoma brucei infected rats were evaluated. The drug conjugation was carried out by adding gold nanoparticle to PEG and diminazene aceturate. A group of infected rats were treated with free diaminazene aceturate, while other groups were treated with conjugated drug at different drug release time interval. Results revealed complete parasite clearanc...

Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolavir

Abstract Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury.  This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. KV was administered at a dos...

Efficacy of Combined Crude Extract of Curcuma longa and Moringa oleifera in the Prevention of Peptic Ulcer in Albino Rats

Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcumalonga and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats.Place and Duration of Study: This research was carried out in Ibadan Nigeria betweenNovember 2017 and January, 2018.Methods: Fifty (50) healthy male albino rats with body weights between 150 and 200 g were usedfor this study. They were randomly divided into ten groups of five rats each. Group I was  admi...

Hepatoprotective Effect of Parkia biglobosa on Acute Ethanol-induced Oxidative Stress in Wistar Rats

Aim: This study is aimed at investigating the hepatoprotective effect of Parkia biglobosa on acuteethanol-induced oxidative stress in wistar rats.Methods: P. biglobosa was purchased from a local market at Orita-Challenge area of Ibadan,Nigeria. They were sun dried and milled into powder using an electronic blender (Moulinex). Thepowder was extracted using n-hexane. Twenty adult male wistar rats with body weight between120 and 150 g were purchased from the Central Animal House, College of Medi...

Nutritional and AntiNutritional Evaluation of Garri Processed by Traditional and Instant Mechanical Methods

Aim: The aim of this study is to evaluate the nutritional and anti-nutritional composition of garriprocessed by traditional and instant mechanical methods.Place and Duration of Study: This study was carried out in Achara, Uturu and analyses weredone at the Biochemistry and Central Laboratories of Gregory University, Uturu, Abia Statebetween March and July, 2017.Methods: Cassava was harvested and processed in Achara area of Uturu, Abia State. For garriprocessed by instant mechanical method, ca...

Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats

Background: African locust bean is a condiment believed to be for the people of low class. Itshealth importance has not been fully known especially to the so-called high class.Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar andlipid profile of albino rats.Methods: African locust bean (ALB) was purchased from a local market at Orita-Challenge area ofIbadan, Nigeria. They were sun dried and milled into powder using an electronic blender. Thepow...

Toxicological Effect of Monosodium Glutamate in Seasoning on Human Health

The use of seasonings to enhance the flavor of food has been on the increase in recent time. Different types of seasonings are produced daily. Theconstituent of these flavor-enhancers is unknown to ignorant consumers. They only want to eat food with good taste without consideration of theeffect of these additives on their health. These seasonings contain monosodium glutamate (MSG) which really spiced the food. This review focuses onthe toxicological effect of monosodium glutamate in seasoning...

Quality Assessment of Sachet and Bottled Water in Ogbomoso Metropolis, Nigeria

Background: Access to potable water has become a difficult task in many countries of the worldincluding Nigeria. In Nigeria, the government is trying her best to make water supply available tothe masses but till now this vision has never been accomplished. If those living in urban areascould not have access to portable water supply by the government, what is the fate of the peopleliving in rural areas? This has led to increased usage of sachet and bottled water as portabledrinking water.Aim: ...

Assessment of Sachet and Bottled Water Quality in Ibadan, Nigeria

Background: With the recent increase in the consumption of sachet and bottled water in major cities and towns of Nigeria due to lack of portable drinking water, there is need to investigate the prevalence of possible contaminants in these water that may have toxicological effect on human when consumed.Aim: Quality assessment of sachet and bottled water produced and/or sold in Ibadan, Nigeria was the aim of this study.Place and Duration of Study: This research was carried out in Ibadan, the Oy...

Evaluation of Phytochemical Content and Antioxidant Potential of Ocimum gratissimum and Telfairia occidentalis Leaves

Aim: The aim of this study is to compare the phytochemical content and antioxidant potential of Ocimum gratissimum and Telfairia occidentalis leaves.Study Design: This study was made to fit a one-way Analysis of Variance.Place and Duration of Study: This research was carried out in the Department of Premedical Science, Educational Advancement Centre, Ibadan and Pharmaceutical Laboratory of the University of Ibadan, Nigeria between January and June, 2018.Methods: Both plants were purchase...

Evaluation of Moringa oleifera Leaf Potential in the Prevention of Peptic Ulcer in Wistar Rats

This study is aimed at investigating the potential ofaqueous extract of Moringa oleifera leaf in theprevention of indomethacin-induced ulcer. Toachieve this, thirty adult male rats of body weightbetween 150 and 200g were divided into six groupsof five rats each. Group I was treated with 0.8mg/mlof Omeprazole for seven days. Group II was treatedwith a solution of 0.8 g/ml Moringa oleifera leaf forseven days, while group III received distilled waterfor seven days. This group served as the contr...

Comparative Assessment of Phytochemical Content and Antioxidant Potential of Azadirachta indica and Parquetina nigrescens Leaves

Aim: The aim of this study is to compare the phytochemical content and antioxidant potential of Azadirachta indica and Parquetina nigrescens leaves.Study Design: This study was made to fit a one way Analysis of Variance.Place and Duration of Study: This research was carried out in Premedical Science Department, Educational Advancement Centre, Ibadan and Pharmaceutical Laboratory of the University of Ibadan, Nigeria between January and June, 2018.Methodology: Both plants were harvested fr...


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