Objective: Materials and This study was aimed to investigate . whether levofloxacin perturb lipid metabolism
methods: 7.14 mg/kg body weight) of levofloxacin was administered intraperitoneally 12 hourly to Therapeutic dose (
rats for 5 and 10 days. Twenty-four hours after the last levofloxacin treatment and 7 days after levofloxacin withdrawal
(for a group of rats), blood and other tissues (liver, kidney, brain, heart, lung and spleen) were removed from the animals
after an overnight fast and analysed for their lipid contents. Levofloxacin administration resulted in Results:
dyslipidemia in different compartments investigated. characterised Plasma and erythrocyte dyslipidemia were by
increased concentrations of phospholipid, free fatty acids (FFA) and depletion of cholesterol. It also resulted in kidney
and heart cholesterogenesis, while spleen and lung cholesterol were reduced. Liver cholesterol was unaffected.
Administration of the drug equally produced phospholipidosis in the kidney, lung and liver while brain and heart
phospholipids decreased. Lipoprotein abnormalities were reflected as up-regulation of HDL triglyceride and
phospholipid as well as down-regulation of VLDL-LDL cholesterol and phospholipid. Hypertriglyceremia was the
hallmark of dyslipidemia in the plasma, kidney, lung and brain while in the heart and erythrocyte triglyceride level was
decreased. The distortion observed in the lipid profile in most of the compartments of the animals studied, Conclusion:
suggest that induction of dyslipidemia might represent additional adverse effects of levofloxacin.
Augustine, A (2019). Levofloxacin induced dyslipidemia in male albino rats -. Afribary.com: Retrieved March 05, 2021, from https://afribary.com/works/levofloxacin-induced-dyslipidemia-in-male-albino-rats
Airaodion, Augustine. "Levofloxacin induced dyslipidemia in male albino rats -" Afribary.com. Afribary.com, 29 Mar. 2019, https://afribary.com/works/levofloxacin-induced-dyslipidemia-in-male-albino-rats . Accessed 05 Mar. 2021.
Airaodion, Augustine. "Levofloxacin induced dyslipidemia in male albino rats -". Afribary.com, Afribary.com, 29 Mar. 2019. Web. 05 Mar. 2021. < https://afribary.com/works/levofloxacin-induced-dyslipidemia-in-male-albino-rats >.
Airaodion, Augustine. "Levofloxacin induced dyslipidemia in male albino rats -" Afribary.com (2019). Accessed March 05, 2021. https://afribary.com/works/levofloxacin-induced-dyslipidemia-in-male-albino-rats