Potential Biological Applications Of Bio-Based Anacardic Acids And Their Derivatives

Abstract: Cashew nut shells (CNS), which are agro wastes from cashew nut processing

factories, have proven to be among the most versatile bio-based renewable materials in the

search for functional materials and chemicals from renewable resources. CNS are produced

in the cashew nut processing process as waste, but they contain cashew nut shell liquid

(CNSL) up to about 30–35 wt. % of the nut shell weight depending on the method of

extraction. CNSL is a mixture of anacardic acid, cardanol, cardol, and methyl cardol, and

the structures of these phenols offer opportunities for the development of diverse products.

For anacardic acid, the combination of phenolic, carboxylic, and a 15-carbon alkyl side

chain functional group makes it attractive in biological applications or as a synthon for the

synthesis of a multitude of bioactive compounds. Anacardic acid, which is about 65% of

a CNSL mixture, can be extracted from the agro waste. This shows that CNS waste can be

used to extract useful chemicals and thus provide alternative green sources of chemicals,

apart from relying only on the otherwise declining petroleum based sources. This paper

reviews the potential of anacardic acids and their semi-synthetic derivatives for

antibacterial, antitumor, and antioxidant activities. The review focuses on natural anacardic

acids from CNS and other plants and their semi-synthetic derivatives as possible lead

compounds in medicine. In addition, the use of anacardic acid as a starting material for the

synthesis of various biologically active compounds and complexes is reported.