Carbon –U (C-11) radiotracers are widely used for the early diagnosis of cancer, monitoring therapeutic response to cancer treatment and pharmacokinetic investigations of anticancer drugs. PET imagining permits non-invasive monitoring of metabolic processes and molecular targets, while carbon-II radiotracers allow a “hot-for cold” substitution of biological active molecules. Advance in organic synthetic chemistry and radiochemistry as well as improved automated techniques for radiosynthesis have encouraged investigators in developing carbon-II tracers for use in oncology imagining studies. The short half-life of carbon –II (20.38 minutes) creates specially challanges for the synthesis of carbon –II labeled tracers: these include high radiochemical parity and high specific activity in a short time and on a very small scale. The optimization of conditions for makers a carbon-II tracer include the late introduction of the carbon-II Isotope, the rapid formation and purification of the target compound, and the used automated system to afford a high yield of the target compound in a short time. In this review paper, we first briefly introduced some basic principles.
PET imaging of cancer, we then discuss principles of C-II radiochemistry, focus on specific advances in radiochemistry and describe the synthesis of carbon-II radiopharmaceuticals developed for cancer imaging. The carbon-II radio chemistry approaches described include the N,D and S-alkylation of (C-II) methyl iodide (C-11) methyl triflate and analogues of (C-11) methyl iodide and heir application for making carbon-II tracers; we then address recent advances in exploring a trans metallic complied medicate (C-11) carbonyl reaction for oncologic targets.
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APA
Udebunu, F.
(2018). PRINCIPLES OF CARBON-U (C-11) RADIO-CHEMISTRY. Afribary. Retrieved from https://afribary.com/works/principles-of-carbon-u-c-11-radio-chemistry-6039
MLA 8th
Udebunu, Frederick
"PRINCIPLES OF CARBON-U (C-11) RADIO-CHEMISTRY" Afribary. Afribary, 29 Jan. 2018, https://afribary.com/works/principles-of-carbon-u-c-11-radio-chemistry-6039. Accessed 24 May. 2022.
MLA7
Udebunu, Frederick
. "PRINCIPLES OF CARBON-U (C-11) RADIO-CHEMISTRY". Afribary, Afribary, 29 Jan. 2018. Web. 24 May. 2022. < https://afribary.com/works/principles-of-carbon-u-c-11-radio-chemistry-6039 >.
Chicago
Udebunu, Frederick
. "PRINCIPLES OF CARBON-U (C-11) RADIO-CHEMISTRY" Afribary (2018). Accessed May 24, 2022. https://afribary.com/works/principles-of-carbon-u-c-11-radio-chemistry-6039
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