Research Papers/Topics in Chemistry

Preparation of Some 4- diazo (hetero aryl)phenyl pyrazole and 2-diazo(hetero

Abstract In the present work fifty six a new α, β - unsaturated carbonyl compounds and their cyclization reactions with varieties reagent (hydrazine derivatives, hydroxylamine and thio urea) pyrazole, isoxazole and thiopyrimidine derivatives were prepared. A process of the preparation of α, β – unsaturated carbonyl compounds by coupling to diazotized a p-aminoacetophenone with 1.3 di carbonyl compounds (ethyl acetoacetate, acetyl acetone, bezoylacetone and dimedone) in presence sodium...

Synthesis and Evaluation for Biological Activities of Npyridin-3-Yl Substituted [Phenylsulphonamido] Acetamide

ABSTRACT In this study, a series of N-pyridin-3-yl substituted [phenylsulphonamido] acetamide has been synthesized. The reaction of phenylsulphonyl chloride with various amino acids in basic medium yielded phenylsulphonamido alkanoic acid which, on chlorination with thionyl chloride, gave acid chloride derivatives of phenylsulphonamido alkanoic acid in situ. The acid chloride derivatives on condensation with 3-aminopyridine gave corresponding acetamide in good to excellent yield. The compoun...

ALPHA-AMYLASE INHIBITORY COMPOUNDS FROM LANNEA SCHWEINFURTHII STEM BARK AND THEIR MODES OF INHIBITION

ABSTRACT Management of hyperglycemia is an essential strategy in control of diabetes mellitus which remains a major health problem despite several therapeutic interventions particularly inhibitors of a-amylase. Use of ethnobotanical options has prominently been reported, for instance, Lannea schweinfurthii reported for management of hyperglycemia, although there is no scientific information to validate its anti-hyperglycemic potential. The study was to determine structures of compounds from L...

Effect of Occupational Lead Exposure on Zinc and Chromium Level among Factory Workers

Abstract Introduction: Lead is an oxidation reduction inactive metal however it interacts with a group of essential elements such as copper, zinc, selenium and chrome and iron. Accordingly current study aims to evaluate the effect of occupational Lead exposure on zinc and chromium level among factory workers. Materials and Methods: A cross-sectional study included 41 Lead exposure workers and 40 non exposure subjects as control group. Serum chromium and zinc were measured using Atomic Absorp...

Physico-chemical Parameter Review of Drinking Water Portability at Daranna Community, Bagudo LGA of Kebbi State, Nigeria

Drinking water quality was investigated at Daranna community the mineral rich part of Kaoje town in Kebbi state, to ensure the continuous supply of clean and safe drinking water for the public health protection. In this regard, a physical and chemical analysis of drinking water samples was carried out for samples collected at different locations within the community areas. A number of parameters such as colour, temperature, pH, electric conductivity, dissolved oxygen, total hardness, COD, ...

Potentially Toxic Elements in Food Crops Grown on Urban Waste Dump-Sites A Case Study of Wakaliga Dump-Site, Kampala City, Uganda.

ABSTRACT This study aimed at investigating the seasonal variation in the levels of contamination in soils, food crops, and domestic spring water samples from Wakaliga dumpsite in Kampala. Potentially Toxic Elements (PTE) and physicochemical properties were analysed during the dry season (May-July 2017) and the wet season (September-November 2017) and the results compared to standard limits set by international and local agencies. The results obtained indicated that some of the elements were ...

Assessment of Heavy Metal Concentrations in Food Crops from Pece Wet Land in Gulu Township, Northern Uganda

ABSTRACT The present study is aimed at assessing the concentrations of heavy metals in food crops from pece wet land Gulu town ship. The study investigated heavy metals which include Copper, Zinc, Lead, and Cadmium in the soil and in selected crops which were banana fruit, sugar cane, coco yam and green vegetables (Amaranthus dubius). Metals are essential for maintaining human health throughout life however, at high concentrations they become poisonous. In Gulu town ship, waste disposal and ...

Chemical Characterization of Some Flavonoids from Trianthema prot ulacstrum and phoenix dactylefrera and Their Biological Activity

Abstract  In the present work, the stems of Trianthema portulacastrum and Phoenix d actylefera pollens were extracted with 95% ethanol at ambient temperature. Qualitative tests on alcoholic extract of Trianthema portulacastrum stems re vealed the presence of flavonoids, alkaloids, tannins, saponins, steroids, carb ohydrates and glycosides. The crude extracts of Trianthema portulacastrum and Phoenix daclylefera w ere initially purified by column chromatography. Further purification was ac com...

Synthesis, Characterization and Solvent Extraction Studies of 3,5-Bis[(2-Hydroxybenzylidene)-Amino]-Benzoic Acid and Its Co(Ii) and Ni(Ii) Complexes

ABSTRACT 3,5-Bis[(2-hydroxy-benzylidene)-amino]-benzoic acid (H2B) and its cobalt(II) and nickel(II) complexes were synthesized and characterized via: electronic, IR, 1 H NMR and 13C NMR. Job’s continuous variation method was used to determine the mole ratio for both metal complexes. Solvent extraction studies were carried out on H2B in 5% DMF with its cobalt(II) and nickel(II) complexes using CHCl3 as organic solvent; with variable condition effects of equilibrium time, buffer pH, mineral ...

Toxicological Studies on Organic Manures Derived from Municipal Solid Waste in Makindye, Rubaga and Kawempe Divisions of Kampala, Uganda

ABSTRACT The study was carried out to estimate the levels of contamination and marketability of organic compost manures, derived from Kampala municipal solid wastes (MSW), sold along roads in the various suburbs of Kampala. The organic composts were sampled from five locations: Kawempe (KWP); Bwaise (BWS); Kitebi (KTB); Wankulukuku (WKK) and Ggaba-Kansanga (GGK~. The overall quality of the compost manures was determined by investigating selected physicochemical, trace metals and fertilizing p...

Potentially Toxic Elements in Food Crops Grown on Urban Waste Dump-Sites A Case Study of Wakaliga Dump-Site, Kampala City, Uganda

ABSTRACT  This study aimed at investigating the seasonal variation in the levels of contamination in soils, food crops, and domestic spring water samples from Wakaliga dumpsite in Kampala. Potentially Toxic Elements (PTE) and physicochemical properties were analysed during the dry season (May-July 2017) and the wet season (September-November 2017) and the results compared to standard limits set by international and local agencies. The results obtained indicated that some of the elements were...

Assessment of Heavy Metal Pollution in Pece Channelized Stream Water Gulu Town, Northern-Uganda

ABSTRACT Water quality monitoring in developing countries is inadequate, especially in stream water affected by urban effluents and runoff. The purpose of this study was to investigate heavy metal contaminants in the Pece Stream water in Gulu Municipality, Northern-Uganda. Water samples were collected along the channel of Pece stream and other samples from Nakaseke River which served as a control site. Selected heavy metals (Zinc, Copper, Lead and Cadmium) were determined using Atomic Absorp...

Investigation of The Physicochemical, Microbial and Trace Metals Properties of Selected Packaged Drinking Water Sold in Kansanga, Kampala, Uganda.

ABSTRACT This study aimed at investigating the physicochemical and microbial properties of Packaged Drinking Water, sold in Kansanga, Kampala. Seventy-two samples were selected by systematic random sampling from local stores in the study area. Three types of Packaged Drinking Water samples (bottled, sachet and handtied) were selected. Spring water samples were used as control samples. Titrimetric techniques were used to determine the Chlorides, Alkalinity and the Total Hardness, while Nitroge...

Effect of sintering additives on the densification and dielectric properties of Sr0.5Ba0.5Nb2O6 ceramics synthesized by a soft-chemistry method

Nano-crystalline Sr0.5Ba0.5Nb2O6 powders with addition of LiNbO3 or LiF as sintering additives were prepared by a soft-chemistry synthesis using polyethylene glycol. Calcination at 600 C results in nanocrystalline powders (dcryst. 30 nm) which were sintered between 1000 and 1300 C to ceramic bodies. By addition of 10 and 20 mol % LiNbO3, the sintering temperature was reduced by about 200 K and the activation energy of the initial stage of sintering decreases from 386 to 271 kJ mol1. The sinte...

In-vivo Anti-inflammatory Activity Studies of Some P-nitrophenyl Hydrazones

The goal of this research was the discovery of newer anti-inflammatory drug. Four hydrazones with p-nitrophenyl moiety were synthesized by solvent-free and conventional synthetic methods with good to excellent yields. The synthesized hydrazones were evaluated for their anti-inflammatory activities using carrageenan-induced paw edema in mice. All the compounds indicated significant anti-inflammatory activity, demonstrating slow onset of action and longer duration of action compared to celecoxi...


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