Prophylactic Efficacy of Aqueous Extract of Curcuma longa against Indomethacin-Induced Ulcer in Male Wistar Rats

Augustine Airaodion 5 PAGES (2602 WORDS) Article
Subscribe to access this work and thousands more

Evaluation of the anti-ulcerogenic and
prophylactic efficacy of aqueous extract of
Curcuma longa on indomethacin-induced ulcer in
albino rats was the aim of this study. Thirty adult
male rats of body weight between 150 and 200g
were used and were divided into six groups of five
rats each. Group I was treated with 0.8mg/ml of
Omeprazole for seven days. Group II was treated
with a solution of 0.8 g/ml Curcuma longa for
seven days, while group III received distilled water
for seven days. This group served as the control
group. Groups IV, V and VI were treated similarly
as groups I, II and III respectively but were treated
for fourteen days. Gastric ulceration was induced
in the rats by the administration of 50 mg/kg
indomethacin after pre-treatment with distilled
water, omeprazole and Curcuma longa for 7 and
14 days respectively. Significant ulcer inhibition
was produced in the groups treated with Curcuma
longa and Omeprazole when compared with
control groups at p<0.05, but omeprazole-treated
group showed greater ulcer inhibition (72.60 %
and 74.29 %) when compared with the Curcuma
longa -treated groups (46.53% and 43.84%) after 7
and 14 days respectively. This study showed that
Curcuma longa possesses anti-ulcerogenic
properties and can be used as herbal remedy for
the prevention of gastro-intestinal ulcers
  

Subscribe to access this work and thousands more
Overall Rating

0

5 Star
(0)
4 Star
(0)
3 Star
(0)
2 Star
(0)
1 Star
(0)
APA

Augustine, A (2019). Prophylactic Efficacy of Aqueous Extract of Curcuma longa against Indomethacin-Induced Ulcer in Male Wistar Rats. Afribary.com: Retrieved March 09, 2021, from https://afribary.com/works/prophylactic-efficacy-of-aqueous-extract-of-curcuma-longa-against-indomethacin-induced-ulcer-in-male-wistar-rats

MLA 8th

Airaodion, Augustine. "Prophylactic Efficacy of Aqueous Extract of Curcuma longa against Indomethacin-Induced Ulcer in Male Wistar Rats" Afribary.com. Afribary.com, 29 Mar. 2019, https://afribary.com/works/prophylactic-efficacy-of-aqueous-extract-of-curcuma-longa-against-indomethacin-induced-ulcer-in-male-wistar-rats . Accessed 09 Mar. 2021.

MLA7

Airaodion, Augustine. "Prophylactic Efficacy of Aqueous Extract of Curcuma longa against Indomethacin-Induced Ulcer in Male Wistar Rats". Afribary.com, Afribary.com, 29 Mar. 2019. Web. 09 Mar. 2021. < https://afribary.com/works/prophylactic-efficacy-of-aqueous-extract-of-curcuma-longa-against-indomethacin-induced-ulcer-in-male-wistar-rats >.

Chicago

Airaodion, Augustine. "Prophylactic Efficacy of Aqueous Extract of Curcuma longa against Indomethacin-Induced Ulcer in Male Wistar Rats" Afribary.com (2019). Accessed March 09, 2021. https://afribary.com/works/prophylactic-efficacy-of-aqueous-extract-of-curcuma-longa-against-indomethacin-induced-ulcer-in-male-wistar-rats