Synthesis and Characterization of Some Antibiotic-Silver Nanoparticles Complexes and their Antibacterial Efficiency

Abstract

Over the last few decades, the applications of nanotechnology in medicine have been extensively explored in many medical areas, especially in drug delivery. Nanotechnology concerns the understanding and control of matters in the 1-100 nm range, at which scale materials have unique physicochemical properties including ultra-small size, large surface to mass ratio, high reactivity and unique interactions with biological systems [1]. Drug-loaded nanoparticles can be achieved through physical encapsulation, adsorption, or chemical conjugation, the pharmacokinetics and therapeutic index of the drugs can be significantly improved in contrast to the free drug counterparts. Many advantages of nanoparticle-based drug delivery have been recognized, including improving serum solubility of the drugs, prolonging the systemic circulation lifetime, releasing drugs at a sustained and controlled manner, preferentially delivering drugs to the tissues and cells of interest, and concurrently delivering multiple therapeutic agents to the same cells for combination therapy [2]. Moreover, drug-loaded nanoparticles can enter host cells through endocytosis and then release drug payloads to treat microbes-induced intracellular infections. As a result, a number of nanoparticle-based drug delivery systems have been approved for clinical uses to treat a variety of diseases and many other therapeutic nanoparticle formulations are currently under various stages of clinical tests