Abstract The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such properties. However, very limited information is available about their mechanism of action. The aim of this study was to determine the mechanism of action of tyrocidine peptides, tyrocidine A, tyrocidine B and tyrocidine C. Chapter 3 explored the structur...
ABSTRACT Three medicinal plant parts, including the leaves of Senna alata, Ricinus communis and the stem bark of Lannea barteri were used for the current study. The aim was to investigate the antimicrobial effect of the crude extracts alone, their combinations and the crude extracts formulated individually with polyethylene glycol (PEG) and Shea butter, as well as phytochemical screening of the medicinal plants crude extracts. The microorganisms employed in this study were E. coli, S. aureus...
ABSTRACT The adsorptive ability of mUCIn onto hydroxyapatite was evaluated based on its adsorptive amount and adsorptive strength. The adsorptive amount was determined by measuring the amount of mucin adsorbed onto hydroxyapatite while adsorptive strength was determined by measuring the amount of mucin remaining adsorbed after rinsing. The amount of mucin adsorbed onto the substrates in all cases followed the order Sigma grade HAP> synthesized HAP> CHP and generally increased with increa...
ABSTRACT The continuous production of antibodies with desired properties has become very important in fields, such as biomedical research and in medicine. Methods for making such useful antibodies include the hybridoma technology and Epstein-Barr virus (EBV) transformation of antibody- secreting cells (ASCs) to make them live longer in ex vivo culture. Transformed cells are then capable of multiplying rapidly over longer periods and producing large amounts of the desired antibodies. The aim ...
ABSTRACT Euphorbia balsamifera plant belongs to the family of Euphorbiaceae. Leaves, stems and roots of Euphorbia balsamifera were extracted using ethanol and the extracts were screened for phytochemical components. The phytochemical results indicated that the plant contained tannins, flavonoids, saponins, steroids, glycosides, terpenoids, alkaloids, and anthraquinones. Ethanol extract of leaves and its fractions were tested for antibacterial activity using agar well diffusion method an...
Abstract Characterization and analysis of Gwandu clay deposits has been conducted with a view to finding its possible industrial applications. The chemical analysis was carried out using XRF and thermal stability was determined using TGA. While the physical property tests such as firing shrinkage, porosity, cold crushing strength, bulk density, thermal shock resistance and refractoriness were done. The results of chemical analysis indicates that Dabagi clay is composed of SiO2 (64.50%), ...
Abstract Attempt was made to determine the nutritional and anti nutritional composition of Wild melon (C. ecirrhosus ) popularly known as “Gunar shanu in Hausa land, using suitable methods of analyses. The results for proximate analyses (% DW) showed a composition of 3.73 ± moisture, 2.12 ± 0.08 ash content, 26.36 ± 0.10 crude protein, 50.67 ± crude lipid, 2.17 ± 0.29 crude fibre, 18.69 ± 0.82 carbohydrate and energy value of 601.7 ± 8.75 Kcal/ 100g. Amino acids determination re...
ABSTRACT Coconut seeds was investigated for its use as biodiesel feedstock. Oil was extracted from coconut seeds using soxhlet extraction method where 67.2% yield of oil was obtained. Biodiesel synthesis was developed and optimized using Box-Behnken design in Response Surface Methodology to study the effect of experimental variables such as methanol to oil ratio, catalyst concentration, reaction temperature and reaction time on the extracted oil from coconut seeds. The model shows optim...
ABSTRACT Quaternary ammonium compound was synthesized from epoxy and fatty amine reaction. Fourier Transform Infrared(FTIR) spectrometric analysis of the starting materials, and the final product(N-benzyl-N,N-dioctyl-2-hydroxy-3 phenoxypropylammonium chloride) were conducted, and results showed a disappearance of sharp N-H peak of 2o amine, and appearance of broad O-H peak of alcohol in the spectrum of the final product. Mass spectrometric(MS)analysis of the final product was also conducted, ...
ABSTRACT This study examined the nephrotic effect of Buchholzia coriacea formulated diet in sucrose-fed pregnant rats and their offspring. Buchholzia coriacea (B. coriacea) (family, capparidaceae) is a perennial plant commonly known as wonderful kola. Seeds were obtained from ogbete main market, Enugu state, identified, dried and grounded using a miller machine. 10% of the seed powder was used to formulate their diet. Thirty (240) adult female and six (6) adult male albino rats (180-250 g...
ABSTRACT Sample of waste collected at Kanwuri Area Sokoto, was analyzed using a groundnut shell and tea bag as natural adsorbent, by adopting the method of atomic absorption spectrophotometry. And this research showed that groundnut shell and tea bag can be effectively used as an excellent adsorbent for the removal of Cu, Zn, Pb, and Cr, from aqueous solution. This study also highlights the effect of different parameters such as, contact time, PH, adsorbent dose initial concentration of heav...
ABSTRACT The potentials of large scale solar photovoltaic power generation in Sokoto State, North-Western Nigeria and Port Harcourt, Southern Nigeria were evaluated through the application of solar PV Sys computer software. Daily average solar radiation in both locations and average relative humidity from 2001 to 2010 was obtained from Nigerian Metrological Weather Forecast Centre, Abuja. The data together with recorded Minimum/Maximum Temperatures were applied as simulation input param...
Abstract Eighteen trace heavy metals were quantitatively analyzed using atomic absorption spectroscopy; five samples of petroleum products were collected from Kaduna Refining and Petrochemical Company. Three different preparation methods were adopted for the determination of trace and heavy metals present in the various petroleum products viz: Direct sample aspiration into the flame after solvent dilution, Total acid (wet) digestion of the sample, Ashing of the sample and dissolution wi...
Bioconversion of agricultural waste products to produce value-added food products like simple sugar; fuels and chemicals offers potential economic, environmental and strategic advantages over traditional fossil-based products. A comparative study on the effect of temperature and concentration on waste cellulose biomass degradation to glucose was studied at temperature range of 80 – 1300C and concentration range of 2, 4, 4.5, 5.0, 5.5 and 6Mol/dm3 for a period of 48hours. The percent...
Nanocellulose prepared from the natural material has a promising wide range of opportunities to obtain the superior material properties towards various end-products. In this study, commercially available natural cotton was treated with aqueous sodium hydroxide solution to eliminate the hemicellulose and lignin, then cellulose was collected. The collected cellulose was subjected to acid hydrolysis using sulphuric acid to obtain nanocellulose. The prepared nanocellulose was further characterize...