Antihaemolytic effect of ethanolic leaf extract ofVernonia amygdalina in Wistar rats is the aim of thisstudy. Fresh plants of V. amygdalina were harvestedfrom the Institute of Agricultural Research andTraining, Ibadan. The leaves were carefully removedfrom the stem and washed in running water toremove contaminants. They were air dried at roomtemperature in an open laboratory space for 14 daysand milled into powder. The extraction was doneusing soxhlet apparatus and ethanol as the solvent.Etha...
Preventive and therapeutic activities of methanolicextract of Talinum triangulare leaves againstethanol-induced oxidative stress in wistar rats is theaim of this study. Fresh plants of T. triangulare werepurchased at a local market in Orita-Challenge,Ibadan. The leaves were dried and extracted usingsoxhlet apparatus and methanol as the solvent. Themethanol was evaporated in a rotary evaporator at35 oC with a yield of 2.76 g which represents apercentage yield of 11.04%. Twenty Wistar rats with...
Objective: To determine the noxious attribute of methanol extract of Nigeria bee propolis at 300 and 600 mg/kg body weight in rats. Methods: Healthy Wistar rats were indiscriminately assigned into three groups (A-C) of five rats each. The control rats (Group A) were orally given 0.5 mL of dimethyl sulfoxide daily for 21 days while rats in Groups B and C were administered the same 0.5 mL dimethyl sulfoxide containing 300 and 600 mg/kg body weight methanol extract of bee propolis respective...
Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome ...
Te study aims to determine the association of malaria infection with ABO blood groups and genotype and also to detect point mutations at positions 86, 184, 1034, and 1042 of the Plasmodium falciparum multidrug resistance gene (pfmdr1) in blood samples collected from pregnant women attending General Hospital Minna. Out of 250 pregnant women screened, 39 (15.60%) had malaria infection. Prevalence was higher in women, during the third trimester (46.15%), genotype AA (64.10%), and O blood group (...
Abstract The enhanced safe drug delivery properties of polyethylene glycol (PEG) – modified Diaminazene aceturate nanocomposite against Trypanosoma brucei infected rats were evaluated. The drug conjugation was carried out by adding gold nanoparticle to PEG and diminazene aceturate. A group of infected rats were treated with free diaminazene aceturate, while other groups were treated with conjugated drug at different drug release time interval. Results revealed complete parasite clear...
Abstract Disruption of electrolyte, redox and neurochemical homeostasis alongside cellular energy crisis is a hallmark of cerebral ischaemia and reperfusion injury. This study investigated the effect of kolaviron (KV) on cortical and striatal cation imbalance, oxidative stress and neurochemical disturbances as well as neurobehavioural deficits in animals subjected to bilateral common carotid artery occlusion (BCCAO)-induced ischaemia/reperfusion injury. KV was administered at a dose of 100...
Aim: This study is aimed at investigating the prophylactic efficacy of combined extract of Curcumalonga and Moringa oleifera leaf against indomethacin–induced ulcer in albino rats.Place and Duration of Study: This research was carried out in Ibadan Nigeria betweenNovember 2017 and January, 2018.Methods: Fifty (50) healthy male albino rats with body weights between 150 and 200 g were usedfor this study. They were randomly divided into ten groups of five rats each. Group I was administered...
Aim: This study is aimed at investigating the hepatoprotective effect of Parkia biglobosa on acuteethanol-induced oxidative stress in wistar rats.Methods: P. biglobosa was purchased from a local market at Orita-Challenge area of Ibadan,Nigeria. They were sun dried and milled into powder using an electronic blender (Moulinex). Thepowder was extracted using n-hexane. Twenty adult male wistar rats with body weight between120 and 150 g were purchased from the Central Animal House, College of Medi...
Aim: The aim of this study is to evaluate the nutritional and anti-nutritional composition of garriprocessed by traditional and instant mechanical methods.Place and Duration of Study: This study was carried out in Achara, Uturu and analyses weredone at the Biochemistry and Central Laboratories of Gregory University, Uturu, Abia Statebetween March and July, 2017.Methods: Cassava was harvested and processed in Achara area of Uturu, Abia State. For garriprocessed by instant mechanical method, ca...
Background: African locust bean is a condiment believed to be for the people of low class. Itshealth importance has not been fully known especially to the so-called high class.Aim: This study is aimed at investigating the effect of African locust bean on fasting blood sugar andlipid profile of albino rats.Methods: African locust bean (ALB) was purchased from a local market at Orita-Challenge area ofIbadan, Nigeria. They were sun dried and milled into powder using an electronic blender. Thepow...
The use of seasonings to enhance the flavor of food has been on the increase in recent time. Different types of seasonings are produced daily. Theconstituent of these flavor-enhancers is unknown to ignorant consumers. They only want to eat food with good taste without consideration of theeffect of these additives on their health. These seasonings contain monosodium glutamate (MSG) which really spiced the food. This review focuses onthe toxicological effect of monosodium glutamate in seasoning...
Background: Access to potable water has become a difficult task in many countries of the worldincluding Nigeria. In Nigeria, the government is trying her best to make water supply available tothe masses but till now this vision has never been accomplished. If those living in urban areascould not have access to portable water supply by the government, what is the fate of the peopleliving in rural areas? This has led to increased usage of sachet and bottled water as portabledrinking water.Aim: ...
Background: With the recent increase in the consumption of sachet and bottled water in major cities and towns of Nigeria due to lack of portable drinking water, there is need to investigate the prevalence of possible contaminants in these water that may have toxicological effect on human when consumed.Aim: Quality assessment of sachet and bottled water produced and/or sold in Ibadan, Nigeria was the aim of this study.Place and Duration of Study: This research was carried out in Ibadan, the Oy...
Aim: The aim of this study is to compare the phytochemical content and antioxidant potential of Ocimum gratissimum and Telfairia occidentalis leaves.Study Design: This study was made to fit a one-way Analysis of Variance.Place and Duration of Study: This research was carried out in the Department of Premedical Science, Educational Advancement Centre, Ibadan and Pharmaceutical Laboratory of the University of Ibadan, Nigeria between January and June, 2018.Methods: Both plants were purchased fr...