Research Papers/Topics in Biochemistry

ANTI-TRYPANOSOMAL ACTIVITY OF N-HEXANE AND DICHLOROMETHANE EXTRACTS OF VITELLARIA PARADOXA LEAVES ON TRYPANOSOMA BRUCEI BRUCEI INFECTED MICE

African trypanosomosis is a vector-borne disease that is caused by a flagellated protozoon of the genus Trypanosoma. Large populations of human and domestic animals are at risk of infections with trypanosomes in vast areas of sub-Saharan Africa where the disease is endemic. Human infections with trypanosomes are referred to as Human African Trypanosomosis (HAT) while animal infections are known as African Animal Trypanosomosis (AAT). These infections are more prevalent in the rural areas (Ato...

Investigation of the Pancreatic Effect of Buccholzia Coricacea Formulated Diet in Sucrose Fed Pregnant Rats and their Offspring

ABSTRACT Several plants have been used in the treatment of various disorders without scientific basis. The present study examine the pancreatic effect of Buchholzia coriacea formulated diet in sucrose-fed pregnant rats and their offspring. Buchholzia coriacea seeds were obtained from Ogbete main market, Enugu state, identified, dried and grounded using a miller machine. 10% of the seed powder was used to formulate their diet. Thirty (240) adult female and six (6) adult male albino rats (180-2...

Hypolipidemic and Antioxidant Capacity of Methanol Leaf Extract of Kigelia Africana in Alloxan Induced Diabetic Albino Rats

ABSTRACT Diabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats  and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves were g...

Determination of Heavy Metals and Proximate Analysis in Some Selected Cereals

ABSTRACT This research was conducted to determine the concentrations of heavy metals and proximate composition of different cereals (maize, millet and rice). Two different samples each sold in two different markets (Ogbete and Gariki) in Enugu, were used for this work, using atomic, absorption spectrophotometer. The heavy metal screening of the cereal samples showed the presence of arsenic in the range of 0.456ppm-0.955ppm but was not detected in sample E and f which are the two different ric...

Relationship Between Anaemia, Glucose-6-Phosphate Dehydrogenase Deficiency and Oxidative Stress Among Malaria Patients Visiting ESUT Teaching Hospital, Enugu Nigeria

ABSTRACT Malaria is a significant public health problem in the world especially in in sub-Saharan Africa. One of the key contributory factors to the development and progression of malaria and its complications is oxidative stress, a condition characterized by increased production of free radicals or impaired antioxidant defence system. Glucose-6-phosphate dehydrogenase (G-6-PD) produces NADPH which intends regenerate reduced glutathione (GSH), an antioxidant which helps in the removal of free...

Evaluation of Oxytocic Potential of Methanol Extracted sida acuta on Female Albino Rats

ABSTRACT Plants have long been a source of nutrition and therapy to man. The medicinal value of these plants lies in some chemical substances that produce a definite physiological action in the human body. This study evaluated the oxytocic potential of methanol extract of Sida acuta on female albino rats in vitro. Oxytocin was used as a standard drug though it is a biochemically synthesized hormone that act on distant hormone receptor to induce contractions. The methanol extract was prepared...

Phytochemical and heavy metals levels of selected vegetables (Carrot, Lettuce, and Tomato) grown at Kalambaina area Sokoto

The presence study aimed to investigate the phytochemical and heavy metals level in selected vegetables grown in Kalambaina area ,the phytochemical were determined using analytical methods and the heavy metals (Cd, Pb, Zn, Ni, Cr and Cu) concentration in vegetables and water were determined using atomic absorption spectroscopy (AAS). The study indicate the presence of flavanoid, alkaloids, steroids, volatile oil, saponin glycosides in all the vegetables. The concentration of copper was found ...

EFFECT OF CELLGEVITY ON CATALASE ACTIVITY OF RAT MODEL OF PARKINSON DISEASE

Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating the impact o...

Effect of Emilia Sonchifolia on Globulin and Bilirubin level of Winter rat

ABSTRACT  The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifo...

FERTILITY ENHANCING POTENTIAL AND METABOLIC EFFECT OF ETHANOLIC ROOT EXTRACT OF SPHENOCENTRUM JOLLYANUM IN MALE WISTAR RATS

The overall objective of this study is to scientifically evaluate the claimed fertility enhancing potential and to assess the metabolic effect of the ethanolic extract of  Sphenocentrum jollyanum pierre (Menispermaceae) root using male wistar rats as model. The specific objectives include the following ·         To determine the proximate and phytochemical composition of the ethanolic extract of Sphenocentrum jollyanum  (root) this will justify the ethno pharmacological  use of th...

EFFECT OF SWIMMING TRAINING ON COGNITIVE FUNCTION IN SCOPOLAMINE INDUCED DEMENTIA IN MICE.

ABSTRACT The present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on ...

NUTRITIONAL AND ANTI-NUTRITIONAL CONTENTS OF INGREDIENTS USED IN PREPARING GRANULATED DUMPLING (DAMBU)

ABSTRACT Nutritional and antinutritional content of ingredient used in preparing dambu were determined by proximate composition, vitamins, minerals and antinutritional contents analysis. Maize and Moringa flowers were used as the experimental samples and the work was conducted in triplicate which resulted in obtaining the experimental result in mean and standard deviation. Appreciable amount of nutritive composition were obtain in the used maize and Moringa samples. While the antinutritional...

KIDNEY FUNCTION PARAMETERS F PLASMODIUM PASSAGED MICE TREATED WITH CRUDE METHANOLEXTRACT OF AZADIRACHTA INDICA (NEEM)

ABSTRACT  Kidney function parameters were evaluated in plasmodium berghei infected mice treated with crude methanol extracts of Azadirachta indica leaves in this study. A total of  forty (40) male albino mice inoculated with quinine resistant strains of plasmodium berghei were randomized into nine (9) groups of (4) animals each while four additional mice serve as the uninfected control group. Group 1 was treated with tween 80, group 2 treated with 10mg/kg chloroquine while groups 3,4, and 5...

Consumption of green tea (Camellia sinensis)

ABSTRACT Consumption of green tea (Camellia sinensis) may provide protection against chronic diseases, including cancer. Green tea polyphenols are believed to be responsible for this cancer preventive effect, and the antioxidant activity of the green tea polyphenols has been implicated as a potential mechanism. This hypothesis has been difficult to study in vivo due to metabolism of these compounds and poor understanding of the redox environment in vivo. Green tea polyphenols can be direct an...

Antioxidant Defense System in a Germinating P.Vulgaris

Phaseolus vulgaris, Common Bean is a herbaceous annual plant grown worldwide for its edible dry seed (known as just "beans") or unripe fruit (green beans) and a member of the legume family Fabaceae.  They are quite popular amongst the natives because of its high protein, minerals and vitamins content (Gentry et al., 1999). The use of a wide range of chemicals to destroy pests and weeds is an important aspect of agricultural practice in both developed and developing countries but there is a w...


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