ABSTRACT Joloo is a formulation extracted from seven medicinal plants used in folk medicine practice for the management and treatment of breast cancer and some other health malaise in southwestern Nigeria. The study evaluates some of its traditionally acclaimed pharmacological properties in mice and rats as well as the safety of Joloo. Three toxicity levels of study which included acute, subchronic and chronic toxicity were undertaken to evaluate the extract. Joloo was prepared using plants i...
ABSTRACT Accessions Tvu 3788 and IT 99K-377-1, Tvsu 102 and Tvsu 1685 and ACR.91SUWANI-SRC1 and DMR-LSRW of Cowpea (Vigna unguiculata), Bambara groundnut (Vigna subterranean) and Maize (Zea mays) respectively were subjected to lead (Pb) and zinc (Zn) treatment and screened for their ability to tolerate these metals. Accessions Tvu 3788, Tvsu 102 and ACR.91SUWANI-SRC1 of cowpea, bambara groundnut and maize respectively were chosen and used for the experiment. The toxic effects of lead and zinc...
Abstract The marine bacterium Vibrio cholerae produces pyomelanin through the catabolism of L-tyrosine to homogentisic acid. Various types of melanins are used by microbes as defense mechanisms against a variety of environmental stresses. This thesis investigated the defensive role of V. cholerae pyomelanin against exogenous stresses, particularly hydrogen-peroxide (HzOz). A V. cholerae 569B melanin-deficient mutant was created by insertional inactivation of ppdA, which encodes for p-hydroxyp...
ABSTRACT Malaria caused by P. falciparum, is the most life-threatening human parasitic disease, claiming over 400,000 deaths from about 200 million cases in 2017. Despite the yet unsuccessful efforts in the quest for an effective malaria vaccine, antigens expressed in the erythrocytic stage of P. falciparum represent highly promising vaccine candidates given their natural exposure to the immune system. Understanding the mechanism of erythrocyte invasion by P. falciparum mainly during active c...
ABSTRACT Background Placental malaria and preeclampsia are major complications of pregnancy associated with high incidence of maternal/foetal morbidity and mortality particularly in sub-Saharan Africa. Similarities in pathophysiology such as systemic inflammation and generalized endothelial activation/dysfunction exist and are exacerbated in concurrent situations. The combined pathologic and immunologic effects of these pregnancy disorders, prevalent in malaria endemic regions, have not been ...
ABSTRACT The resistance of Plasmodium falciparum to artemisinin and its derivatives underscore the need for new sets of antimalarials with novel mechanisms of action. Towards the development of new, affordable and easily accessible antimalarial drugs for endemic regions, there is the need to screen more compounds for their antimalarial activity. Several studies on different compound classes have been conducted using laboratory strains of P. falciparum. However, not much is known of their pote...
ABSTRACT People living with type 2 diabetes mellitus is on the increase and research has established that there is decreased secretion of testosterone in Type 2 Diabetic Mellitus males which may be linked to decreased levels of kisspeptin secretion that can cause the development of diabetic complications such as erectile dysfunction. Decreased kisspeptin levels have strongly been linked to decreased secretion of gonadotropins from the pituitary gland and this causes type 2 diabetic males to...
ABSTRACT Malaria still poses a global threat despite the enormous research and intervention strategies that have been employed to curb the menace of the disease over the years. This has necessitated the characterization of novel drug targets for the development of new intervention against malaria. In this study, I identified two novel P. falciparum proteins (PF3D7_0410600 and PF3D7_1459400) and used cellular/biochemical approaches to characterize the proteins. Analysis of the protein sequenc...
ABSTRACT Hepatitis B virus (HBV) infection is a major cause of liver inflammation accounting for 887,000 deaths annually. The introduction of HBV vaccines has significantly reduced new cases of the infection, but there are still 65 million people living with the virus in Sub-Saharan Africa. Currently, 10 genotypes (A-J) of HBV have been classified. Several studies have shown that the different HBV genotypes differently influence clinical presentation, progression of liver diseases and respons...
Abstract Every year thousands of people died due to malarial infection, mainly in developingcountries and under developed countries. In most of these places, the infected persons ‘age isbelow five and pregnant women are also affected by malaria, this is due to weak and poorimmunity. Another important reason is lack of awareness about malarial infection. In future, dueto climatic change, disease spreading population of mosquito will increase. It leads to a chanc...
Table of ContentsAcknowledgements .................................................................................................................. IIAbstract ................................................................................................................................... III List of tables ........................................................................................................................... VIList of figures ...............................................
The chromosomes of two cyprinid fishes of the genus Barbus; B. callipterus and B. parablabes were assessed in this study with a view to providing baseline information about the diploid chromosome number, karyotype and morphology. This study reveals that B. callipterus has a diploid chromosome number of 2n = 50, fundamental number of autosomal arms (NFa) of 66, and karyotype formula: 2n = 4m + 6sm + 6st +34T. On the other hand, B. parablabes has a diploid chromosome number of 2n = 50, fundamen...
Background: ABO and Rhesus factor (Rh) blood type are germane in human life in genetics and clinicalstudies.Aim of the study: The review was undertaken with the objective to provide data on the ABO and Rh(D)blood group distribution and gene frequency across Nigeria which is vital for blood transfusion and susceptibility to disease.Materials and methods: Literature search for ABO/Rh blood distribution in Nigeria was done and allele frequencies of A, B, O, D and d were calculated from the frequ...
Chapter one : introductionApplication of nanotechnologyConclusion
ABSTRACT Sunflower (Helianthus annuus L.) is a genus of plants comprising about 70 species. It is famous for its unique nature of heliotropism and is the world’s most important source of oil. Around the world, sunflower production is 31.1m tons,with more than 26 ha under sunflower cultivation. Sunflower stalks have been used as fuel, fodder for livestock, food for poultry, and ensilage. Sunflower seeds were and still are eaten raw, roasted, cooked, ...