Alochol Fatty Disease - ALD

ABSTRACT

Unnecessarily high alcohol consumption is linked to a range of diseases, from common steatosis to steatohepatitis, cirrhosis, and, in some situations, hepatocellular carcinoma. Although the histological description of alcoholic steatohepatitis varies, one common characteristic is the presence of shrinking hepatocyte degeneration. Perivenular, centrilobular, and pericellular fibrosis are all present in varying degrees. There may be precirrhotic portal hypertension if the condition is serious and correlated with perivenular liver cell necrosis (central sclerosing hyaline necrosis). The fibrosis pattern can be diffuse at first, with little nodule formation, but micronodular cirrhosis usually develops over time. Hepatocellular carcinoma occurs in about 15% of patients with known cirrhosis; some precursor lesions have now been identified and can be detected clinically. Additional components of the range of alcoholic liver disease, such as vascular changes, portal tract inflammation and fibrosis, ductular reaction, and iron overload, have been identified by several researchers. Avoidance may have a massive effect on the morphology of alcoholic liver disease; additionally, the presence of comorbid conditions such as non-alcoholic fatty liver disease or viral hepatitis could have a significant impact on clinical and morphological phenotype. In alcoholic liver disease, biopsy appearances may provide valuable prognostic details, and this analysis includes a proposed grading and staging framework for evaluating histological severity.

KEY WORDS: Alcoholic liver disease, Alcoholic hepatitis, Cirrhosis, Fatty liver, Alcoholic hepatitis

TABLE OF CONTENT

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Content

Abstract

Introduction

Disease Burden Around the World

Phases and Spectrum of ALD

Etiologies of ALD

Medical Manifestations

Complications of ALD

Treatment of ALD

Conclusion

References