Anti-Infl ammatory Dietary Combo in Overweight and Obese Women with Polycystic Ovary Syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is of clinical and public health importance, affecting up to one in fi ve women of reproductive

age. It has signifi cant and diverse clinical implications including reproductive, metabolic, and psychological features. Aim: The study was to

investigate the effect of anti-infl ammatory dietary combo on metabolic, endocrine, infl ammatory, and reproductive profi les in overweight

and obese women with PCOS. Materials and Methods: A total of 100 nonpregnant, overweight, and obese adult females with PCOS

according to the Rotterdam criteria, were screened during the year 2012, and 75 completed the trial. At baseline and study end, fasting blood

samples were drawn to measure biological markers, body fat percent (BFP), and visceral fat area (VFA) were assessed by the InBody720

device and anthropometric measurements were done for all participants who were subjected to an anti-infl ammatory hypocaloric diet and

physical activity for 12 weeks. Results: At study completion, we achieved moderate weight loss of (± 7%) and signifi cant improvements

in body composition, hormones and menstrual cyclicity, blood pressure, glucose homeostasis, dyslipidemia, C-reactive protein (CRP), and

serum amyloid A (SAA) (surrogate measures of cardiovascular risk (CVR)). This was a clinically relevant weight loss that is associated with

a reduced prevalence of type 2 diabetes mellitus (DM2) and metabolic syndrome (MS) in the general population and improved fertility

outcomes in PCOS. We achieved 63% regain of menstrual cyclicity and 12% spontaneous pregnancy rate within 12 week. Conclusions:

We have explored an additional dietary treatment option with good prognostic metabolic and reproductive responses to weight loss that

occur in overweight and obese PCOS.

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