Antihyperlipidemic and Antioxidant Effects of Phaseolus Vulgaris Linn in Wistar Rats

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ABSTRACT In this study, the antihyperlipidemic and antioxidants activities of the extract and fractions of Phaseolus vulgaris L. were evaluated. The crude extract (PVE) of dried pulverized plant material was obtained by maceration in methylene chloride/methanol (1:1) while the solvent fractions were obtained by successive solvent-solvent partition in separating funnel between the crude extract suspended in aqueous medium and solvents of increasing polarity to obtain the n-hexane fraction (PVHF), ethylacetate fraction (PVEF), and butanol fraction (PVBF) in that order.Antihyperlipidemic effects of the extracts and fractions were investigated using acute, subacute and chronic models. In all threemodels, treatment with (PVE) caused significantreduction (P0.05) increase or decrease in the serum MDA of both the treated and untreated group, while in catalase activity estimation showed significant (P

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