Assessmemt of Anticardiolipin Antibody and Urine Albumin Creatinine Ratio in Sudanese Pregnant Women with Preeclampsia

Abstract

Hypertensive disorders of pregnancy is an umbrella term that includes

preeclampsia (PE) which complicates up to 10% of pregnancies, is the cause of

9% to 26% of global maternal mortality, and represent a significant proportion

of preterm delivery, and maternal and neonatal morbidity.

Is a potentially serious complication of pregnancy as suspected preeclampsia is

the most frequent clinical presentation to obstetric unit. It is associated with

severe complications such as seizures, stroke, and multiple organ failure.

The aim of this study is to assess anticardiolipin antibody and spot urinary

albumin: creatinine ratio in pregnant women patients with preeclampsia.

This cross sectional study was conducted at Omdurman Hospital of Obstetrics

and Gynecology on 80 Sudanese pregnant women according to selection

criteria, and the study carried out in Omdurman Militarily Hospital in Khartoum

State, on a total of 80 samples including 40 Preclamptic females as case group

and 40 healthy pregnant females as controls. Serum anticardiolipin antibody

(IgG aCL) levels was estimated using ELISA method, and urine albumin:

creatinine ratio was estimated using Cobas Integra 400 plus automated analyzer.

Data was analyzed by using the SPSS computer software program version 24.

This study showed that the levels of urine albumin: creatinine ratio was

significantly increased with (P-value= 0.000); while there was insignificant

decrease in levels of IgG anticardiolipin antibody (IgG aCL) with (P-value=

0.517) in preeclampsia patients compared to control group.

Insignificant negative correlation was observed between urine albumin

creatinine ratio level and blood pressure (R=-0.002, P-value=0.989), also an

association between IgG anticardiolipin antibody level and blood pressure was

revealed insignificant negative correlation (R=-0.179, P-value =0.269).

There was insignificant weak positive correlation between levels of urinary

albumin: creatinine ratio and IgG anticardiolipin antibody with value (R =0.295,

P-value =0.064).

From the results and findings of this study, it is concluded that: The urinary

levels of albumin: creatinine ratio are higher in preeclampsia patients, and the

levels of IgG anticardiolipin antibody remained within the normal range in both

case and control groups.

Negative correlation were found between blood pressure of preeclamptic

pregnant women and their levels of urinary albumin: creatinine ratio and IgG anticardiolipin antibody.