COMPARATIVE EVALUATION OF THE DISINTEGRANT PROPERTIES OF STARCH DERIVED FROM Musa Acuminata (MATOOKE BANANA) AND Zea mays (MAIZE) IN PEDIATRIC PARACETAMOL TABLETS

ABSTRACT

The aim of the study was to formulate paracetamol tablets using starch from Musa acuminata

matoke banana as disintegrant in paracetamol tab lets. Paracetamol tablets were produced by wet

granu lation method using Musa acuminata starch as disintegrant in concentrations of 5%, 10%,

and 15% w/w in comparison with offici al corn starch. The physiochemical and material

properties of starches and granu les were evaluated and the properties of paracetamol tablets

prepared by wet granu lat ion using starches as endo -di si ntegrant were determined. The necessary

o !lie ial and non-o lfic ia I tests were performed on the tablets and that include uniformi ty of tablets

l~ight. di ~i ntegrati on te~t. hardness, friabi lity tests and dissolut ion. The results show that the

granules had a fair no''' and values obtained were with in the specified limits for the production

of fai rly good quality tablets. The percentage deviations obtained from the tablet weight

uniformity test were below 7.5%. Tablets disintegration time test ,friability test and hardness test

con formed to the specifications .. The dissolution test also showed that all the tablets in all the

batches had a good drug release profi I e.

Read Download