ABSTRACT: The study evaluated effect of aqueous leaf extracts of C. articulata and M. aethiopicum on serum levels of testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin in male albino rats as well as on organ weights and histological structure of the testis. The phytochemical composition of the extracts was also qualitatively determined. This was an experimental study. Shade dried C. articulata and M. aethiopicum leaves were pounded and crude extracts were prepared using distilled water; then boiled at 100°C for 20 minutes. Adult male rats were randomly divided into eight groups (n=6) and kept in separate cages. The rats from group i-vii were orally dosed daily with 5mg/kg of flutamide to induce erectile dysfunction one hour prior to the administration of the extracts at doses of 150, 300 and 450 mg/kg body weight respectively of each extract. Group vii rats received testosterone, 100μg/kg intraperitoneally while those in group 8 were administered with 10mg/kg of normal saline (negative control). On days 0, 7, 14 and 21 the males from different groups were subjected to estrus induced females in separate cages. The sexual behavior of the rats i.e. mounting and intromission frequencies were recorded. Serum levels of testosterone, LH, FSH and prolactin; organ weights and the histological structure of the testis were determined on day 22 post last treatment. The extracts were also screened for phytochemical composition.Rats treated with 450mg/kg of C. articulata and M. aethiopicum had a significant increase in level of serum testosterone level (p
Ndukui, J., Gakunga1, N , , 2 , Mugisha4, K , Owiny3, D & Waako1, A (2019). Effects of Crude Aqueous Leaf Extracts of Citropsis Articulata and Mystroxylon Aethiopicum on Sex Hormone Levels In Male Albino Rats. Afribary. Retrieved from https://afribary.com/works/effects-of-crude-aqueous-leaf-extracts-of-citropsis-articulata-and-mystroxylon-aethiopicum-on-sex-hormone-levels-in-male-albino-rats
Ndukui, James, et. al. "Effects of Crude Aqueous Leaf Extracts of Citropsis Articulata and Mystroxylon Aethiopicum on Sex Hormone Levels In Male Albino Rats" Afribary. Afribary, 24 Jun. 2019, https://afribary.com/works/effects-of-crude-aqueous-leaf-extracts-of-citropsis-articulata-and-mystroxylon-aethiopicum-on-sex-hormone-levels-in-male-albino-rats. Accessed 07 May. 2024.
Ndukui, James, Ndukui Gakunga1 , 2* , Kamatenesi Mugisha4 , David Owiny3 and And Waako1 . "Effects of Crude Aqueous Leaf Extracts of Citropsis Articulata and Mystroxylon Aethiopicum on Sex Hormone Levels In Male Albino Rats". Afribary, Afribary, 24 Jun. 2019. Web. 07 May. 2024. < https://afribary.com/works/effects-of-crude-aqueous-leaf-extracts-of-citropsis-articulata-and-mystroxylon-aethiopicum-on-sex-hormone-levels-in-male-albino-rats >.
Ndukui, James, Ndukui Gakunga1 , 2* , Kamatenesi Mugisha4 , David Owiny3 and And Waako1 . "Effects of Crude Aqueous Leaf Extracts of Citropsis Articulata and Mystroxylon Aethiopicum on Sex Hormone Levels In Male Albino Rats" Afribary (2019). Accessed May 07, 2024. https://afribary.com/works/effects-of-crude-aqueous-leaf-extracts-of-citropsis-articulata-and-mystroxylon-aethiopicum-on-sex-hormone-levels-in-male-albino-rats