The goitrogenic potential of a plant or food depends upon the amount of active goitrogen present in it. Various procedures like soaking, washing, boiling and cooking can help in reducing the goitrogenic potency of these foods. These, along with the intake of iodide supplements are generally practiced in areas where goitrogenic foods are routinely consumed. In this experiment, goitrogenic contents of some commonly consumed vegetables were assayed and analysed.
The folding protein (and protein folder) is beset with a number of problems in translating the simple instructions encoded by DNA into the complex, three-dimensional structure of a correctly folded protein. Nature has solved these problems in an adequate, if not elegant, fashion, but we are just beginning to understand the variety of strategies that cells use to ensure efficient protein folding. This minireview will focus on several of the more general principles of assisted folding using the...
Extracts of J. gossypifolia L. have been reported to have several medicinal values, including potential anti-cancer and anti-inflammatory properties. In this study, we investigated the anti-clastogenic and hepatoprotective, effects of the ethanolic leaf extract of J. gossypifolia L. in potassium bromate (KBrO3)-induced toxicity in rats. The general trend of the results indicates significant increases (p
We evaluated the brain, lung, and heart oxidative stress in rats exposed to aerosol of an over-thecounter pyrethroid insecticide product in Nigeria. The experimental animals were randomly divided into four groups: group I (control) was not exposed to the insecticide aerosol, while groups II, III, and IV were exposed to 6.0 mL m-3, 12.0 mL m-3, and 18 mL m-3 of insecticide ae...
Background: The current upsurge in the use of polyherbal remedies and coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting also that many of the polyherbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity, hematotoxicity and ...
Extra-pulmonary oxidative stress investigations of exposure to aerosol, of an over-the-counter pyrethroid insecticide product in Nigeria in Wistar rats were carried out. Four groups of five animals each were used in this study, and were exposed to different concentrations of the insecticide aerosol. Malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined in the live...
Introduction: Raw edible camphor (EC), and as component of herbal infusions are widely used to treat pile, back pain, erectile dysfunction, and as an aphrodisiac especially in preparation for sexual intercourse by men. It has been traced in umbilical cord, blood, fetal, adipose, and other tissues including brain, where it bioaccumulates. Methods: The study, therefore, investigated the possible histopathological changes in brain, heart, and spleen that may result following ...
Increasing environmental pollution in the tropics is creating a breeding ground for mosquitoes, leading to increasingly frequent use of insecticides to combat home infestation of mosquitoes, the vector of malarial parasites. Household members are therefore more prone to aerosol exposure and subsequent health effects. We assessed the hepatotoxic and clastogenic effects in rats exposed to different levels of aerosols of one of the insecticides most commonly in used in Nigeria. There were signif...
Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. We therefore carried out this study to investigate the possible ameliorative effects of ginger against the clastogenicity, hepatotoxicity and oxidative stress induced by nitrobenzene (NB) administration in wistar rats. Twenty male wistar rats were divided into four g...
One interesting branch of biochemistry which scientists are still trying to completely unravel is the area of chronobiochemistry. The history of chronobiology is dated 400 B.C., when Androsthenes observes that leaves of certain trees open during the day and close at night. It was only recently that the first human clock gene was discovered. All living organisms possess an internal bio...
ABSTRACT Background: Edible camphor (EC) is one of the ingredients in the preparation of local infusion for the management and treatment of pile, back pain, and erectile dysfunction, which are practices commonly in the south-western part of Nigeria. Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal ...
In living cells, especially eukaryotes, mitochondria involvement appears to be important in the general status of every aspect of life. Apoptosis as a programmed cell death is mandatory to all life process thus, mitochondria might be describe as organelles that serves as a gatekeeper to trap a variety of proapototic protein and prevent the functions of this proteins in the cytosol...
ABSTRACT The present study investigated the ameliorative properties of Diospyroschloroxylon (methanolic) leaf extract (DCLE) in liver of rats intoxicated with N-Nitrosodimethylamine (NDMA). Antioxidant markers- Superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and lipid peroxidation were assayed spectrophotometrically. DNA fragmentation was determined spectrophotometrically. The Bcl-2, Ki-67 and ...
INTRODUCTION This is the good Bio-Technology project on "development of biochemistry liquid stable reagents used for the estimation of Sodium and Potassium electrolytes in blood serum", which covers study based on Sodium and Potassium reagents. Chemical pathology (more commonly known as clinical biochemistry or clinical chemistry) is the area of pathology that is generally concerned with analysis of body fluids and extracts and will be used in this report This research study is based on S...