Research Papers/Topics in Chemistry

THE DEVELOPMENT AND EVALUATION OF ANALYTICAL PROCEDURES FOR THE DETERMINATION OF HEAVY METALS IN INDUSTRIAL EFFLUENTS

This project is concerned with the development and evaluation of an atom trapping technique for determination of heavy metals in environmental samples. Modified atom-trapping technique using fabricated nickel tube/sample holder (crucible) was employed to increase the sensitivity of a flame atomic absorption spectrometry.MBasic performance data for different parameters, such as burner height and the height of the support, were studied. Different designs and ways of placing the atom trap ov...

Persistence And Accumulation Of Organochlorine Pesticides Inselectedcocoafarms In Southwestern Nigeria

ABSTRACT Organochlorine Pesticides (OCPs) are cyclic chlorinated hydrocarbons that are toxic and can bioaccumulate in the environment. Although, its usehas been prohibited in many countries including Nigeria; nevertheless they are still used extensively for pests control by cocoa (Theobroma cacaoL.) farmers in Nigeria. In addition, OCPs residual concentrations among other factors in cocoa bean influences their price in the World market. Therefore, this study was designed toassess the persist...

Impact Of Gold Mining Activities On The Water Quality Of The Lower Pra River

ABSTRACT  This study was conducted to assess the extent of Mercury (THg) contamination at four locations within the Shama-Mporhor Wassa catchment area of the Lower Pra River. Water, fish and sediment samples were taken twice with the longitudinal transect method at Daboase, Beposo, Bokorkope and Shama during the minor rainy season in October and at the apex of the dry season in March. Careful investigation of the Shama-Mporhor Wassa catchment area revealed that two of the locations Daboase a...

Investigation Of The Efficacy And Chemistry Of Selected Traditional Medicines Used In The Treatment Of Schistosomiasis And Their Antitrypanosomal Potential

ABSTRACT This research investigated the efficacy and chemistry of selected traditional medicines (TM) used in the treatment of schistosomiasis and also explored their antitrypanosomal potential. Crude extracts were obtained by successive extraction of dried herbs with dichloromethane and methanol while aqueous herbal preparations were extracted with dichloromethane and butanol. Biological activity was conducted by screening the crude extracts against the schistosomula (NTS) and adult worms of...

Kinetics And Thermodynamic Studies Of Nadp* Binding Reactions Of Genetic Variants Of Human Erythrocyte Glucose 6—Phosphate Dehydrogenase.

ABSTRACT Inherited Glucose-6-Phosphate dehydrogenase (G6PD) deficiency in humans results in hemolytic anaemia. The enzyme G6PD provides a crucial link in a series of biochemical reactions which occur in the red blood cell that leads to the steady state accuralation of NADPH, reduced glutathione by glutathione reductase, and the removal of potentially dangerous organic peroxides which, if not scanvenged, may result in the formation of radical species of oxygen which damage the energy generatio...

Kinetic And Equilibrium Studies Of The Reaction Of 5,5'-Dithiobis(2-Nitrobenzoate) With Haemoglobins Of Dog And Donkey

ABSTRACT The CysF9[93]β sulphydryl group is an indicator for tertiary and quaternary structure change in haemoglobin. Allosteric effectors such as proton and inositol hexakisphosphate (inositol-P6) influence its reactivity. This work was undertaken to study the effects of inositol-P6 and pH on the kinetics and equilibrium of the reaction of CysF9[93]β of dog (Canis familiaris) and donkey (Equus asinus) haemoglobins with 5,5'-dithiobis(2-nitrobenzoate) (DTNB). The number of sulphydryl groups...

The Synthesis Of Some Natural Products Of Medicinal Value Using Organometallic Complexes

ABSTRACT The challenge of accomplishing C-C bond formation while protecting sensitive functional groups and overcoming problems of stereo-control has led to the use of transition-metal organometallic compounds in organic compounds synthesis. Nucleophilic additions to cationic dienyliron carbonyl complexes provide a convenient means of C-C bond formation. It is highly regioselective and stereospecific making it useful for the synthesis of natural products and compounds with biological activiti...

ME EFFECT OF LEACHATE FROM SOLID WASTE DISPOSAL SITES ON THE CAPE COAST MUNICIPAL ENVIRONMENT

ABSTRACT As a developing countJy, Ghana is faced with the problem of management of her solid waste. Disposal ofsolid waste in open dumps and swampy areas in a bid to reclaim the land is the most common method used. This research was carried out at the Cape Coast Municipality to investigate the effect of disposed solid waste on the environment. The methodologies are purposive sampling for the solid waste evaluation, titrimetric and spectrophotometric for the analysis of the leachate from the ...

SYNTHESIS OF THE COMPLEXES OF 4-CY ANOBENZALDEHYDECYCLOHEXYLACE TIC ACIDHYDRAZONE WITH M(II) SULPHATES AND ACETATES. (M= Ni, cu, Co, Zn)

Complexes of 4 - Cyanobenzaldehydecylohexyl acetic acid hydrazone ( 4-CBAH) with M(II) sulphates and acetates have been synthesized (M=Ni, Cu, Co and Zn). The complexes were characterized by elemental analyses, conductance, infrared and electronic spectral studies. The sulphate ions are in the outer coordination sphere, so also the acetate 10ns. The electronic spectral studies of the isolated complexes indicate an octahedral coordination for Ni 2 + and Co 2 + complexes while Cu 2 +...

SYNTHESIS OF A QUATERNARY AMMONIUM SALT FROM EPOXIDE AND FATTY AMINE AND EVALUATION OF ITS ANTIMICROBIAL PROPERTIES

Quaternary ammonium compound was synthesized from epoxy and fatty amine reaction. Fourier Transform Infrared(FTIR) spectrometric analysis of the starting materials, and the final product(N-benzyl-N,N-dioctyl-2-hydroxy-3 phenoxypropylammonium chloride) were conducted, and results showed a disappearance of sharp N-H peak of 2oamine, and appearance of broad O-H peak of alcohol in the spectrum of the final product. Mass spectrometric(MS)analysis of the final product was also conducted, and ...

ASSESSMENT OF THE LEVELS OF HEAVY METALS IN SEDIMENTS, WATER AND FISH FROM THE WEIJA DAM

ABSTRACT This study was conducted to assess the levels of heavy metal contaminations within the Weija dam area of the Weija Lake. Sediments, water and fish samples were taken from ten different sites within the Weija dam in March, 2014 (dry season) and August, 2014 (wet season). The sediment, water and fish samples were analysed for Hg, Se, Fe, Cd, Mn and Pb using Atomic Absorption spectroscopy (AAS). Mercury was determined using a cold vapour technique with the AAS equipped with hydride gene...

SYNTHESIS AND CHARACTERISATION OF NOVEL SEMICONDUCTING SMALL MOLECULES FOR APPLICATIONS IN ORGANIC SOLAR CELLS.

Abstract Five novel semiconducting organic small molecules have been synthesised, fully characterised, and their photovoltaic performance tested in fabricated organic solar cells. Three (molecules 5, 7 and 9) were acceptor-donor-acceptor (A-D-A) small molecules bearing an electron-rich (3,4- ethylenedioxythiophene) EDOT central core with different terminal groups. The additional two (molecules 20 and 21) were truxene derivatives which have been differentiated by the alkyl chain length on the ...

POST MARKETING SURVEILLANCE OF ACTIVE PHARMACEUTICAL INGREDIENTS (API) IN ANTIMALARIAL DRUGS USED IN MALAWI

ABSTRACT The use of poor quality antimalarials causes low bioavailability of the active pharmaceutical ingredients (APIs) to the drug targets resulting in treatment ineffectiveness or failure and parasite resistance over a short period of drug usage. Resistance has rendered the hitherto cheap and effective drugs like chloroquine and sulphadoxine/pyrimethamine ineffective, resulting in their replacement with the more expensive artemisinin-based combination therapy (ACT) for malaria treatment. ...

STUDIES OF VALEROHYDROXAMIC AND ' ISOVALEROHYDROXAMIC ACIDS AND OF THEIR COMPLEXES WITH SOME BIOLOGICALY IMPORTANT METAL IONS

Valerohydroxamic and Isovalerohydroxamic acids were synthesised and recrystallised from ethylacetate. They were characterised by melting point, pka and spectral (IR NMR) studies. Their melting points are 77.78°C and 76.77°C for valerohydroxamic acid and isovalerohydroxamic acid respectively and their pka values at 0.1mol dm-3 at 28°C are 9.50+0.01 and 9.51+0.01 for valerohydroxamic acid and isovalerohydroxamic acid respectively. The IR and NMR (1H and 13C) for both valerohydroxamic...


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