Polymorphisms Of Toll Like Receptor 4 (-8984c/G And 299asp/Gly) And Interferon Gamma Levels In Children With Severe Plasmodium Falciparum Malaria Anaemia In Siaya County, Western Kenya

ABSTRACT

Plasmodium falciparum (P. falciparum) malaria is a major cause of childhood morbidity and mortality in Sub-Saharan Africa despite the integrated approaches put in place to control the disease. Most of the mortality in holoendemic transmission areas occurs due to severe P. falciparum disease complication of severe malarial anaemia (SMA), a condition which largely presents in children below five years. Molecular determinants have been implicated in the pathogenesis of SMA (Hb