Prevalence And Predictors Of Haemodialysis Adequacy Among Patients With End Stage Kidney Disease Attending Haemodialysis Centres In Dodoma, Tanzania

ABSTRACT

Background: The prevalence and mortality due to end stage kidney disease (ESKD) are estimated to be high in Sub-Saharan Africa. Effective haemodialysis reduces complications and promotes better outcomes. Achieving haemodialysis adequacy is challenging in haemodialysis management. In Tanzania, little is known on hemodialysis adequacy in patients with ESKD particularly in Dodoma city. Haemodialysis adequacy refers to the dose of dialysis measured enough to uphold an optimal long-term clinical outcome.

Objective: To determine the prevalence and predictors of haemodialysis adequacy among patients with End Stage Kidney Disease attending haemodialysis centres in Dodoma city, Tanzania.

Methods: A cross-sectional analytical hospital based study was conducted from February, 2020 to July, 2020. Convenience sampling method was used to enroll the study participant. Haemodialysis adequacy was measured using clearance of urea multiplying with treatment duration in hours and then dividing by volume distribution of urea (Kt/v) and Urea Reduction Ratio (URR) levels, the minimum optimal dose targeted for adequacy haemodialysis is Kt/v of ≥ 1.2 and URR is ≥ 65% for thrice weekly dialysis patients. Data were analyzed using SPSS version 25. Chi-square test was used to determine bivariate association of the key selected variables and Logistic regression was used to determine the independent predictors of hemodialysis adequacy. A 95% Confidence interval and P-value of less than 5% was considered statistically significant.