Prevalence Of Virological Failure And Associated Factors Among Hivinfectedadults Receiving Second Line Antiretroviral Therapy In Dodoma City, Tanzania

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ABSTRACT

Introduction: Virological failure is one of the common challenges facing HIVinfected adultsonantiretroviral therapy programmes particularly in resource limited settings. Objective: This study was done to determine the prevalence of virological failure and associated factors among HIV-infected adults receiving second line antiretroviral therapy in Dodoma city, Tanzania. Methodology: A cross-sectional analytical hospital-basedstudy of HIV-infected adults on second line antiretroviral therapy was conducted at care and treatment centres of, Dodoma Regional Referral Hospital and Makole Health Centre.Data collected included social demographic characteristics, antiretroviral drug history, body mass index, Full Blood Picture, CD4 cell counts and viral load.Data were analysed using SPSS version 23. Correlation between viral load and CD4 cell counts were done by using Pearson correlation test. Association between categorical variables and continuous variablesweredone by chi-square test and t-test respectively.Logistic regression analysis was done to determinepredictors of virological failure.A two-tailed P

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