Abstract
Background: The use of conjunctiva autograft, adjunct antimetabolite therapy has been shown to be effective in preventing pterygium recurrence.
Objective :To compare 5 fluorouracil (5-FU) to conjunctival autograft in the treatment of large, fleshy pterygium.
Methods :A randomised controlled prospective study of outcome of pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. Thirty-five eyes with large pterygium treated with bare sclera conjunctival excision plus 5-FU were compared with 33 eyes treated with excision and conjunctival autograft alone.
Results: Post-operative pterygium recurrence was observed in four (11.4%) eyes treated with 5-FU and 4 (12.1%) eyes treated with conjunctiva autograft (P>0.05). The post-operative complications included, granuloma formation 11.4% for 5-FU and 3.0% for autograft and conjunctival discharge 5.7% for 5-FU group only.
Conclusion: 5-FU is marginally superior to conjunctival autograft in the prevention of pterygium recurrence but neither gives a more desirable single digit recurrence rate. Randomised studies combining both conjunctival autograft and 5-FU in pterygium treatment is advocated to further explore their effect.
Bekibele, C & Baiyeroju, A (2021). Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. Afribary. Retrieved from https://afribary.com/works/pterygium-treatment-using-5-fu-as-adjuvant-treatment-compared-to-conjunctiva-autograft
Bekibele, CO and A Baiyeroju "Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft" Afribary. Afribary, 20 Mar. 2021, https://afribary.com/works/pterygium-treatment-using-5-fu-as-adjuvant-treatment-compared-to-conjunctiva-autograft. Accessed 04 May. 2024.
Bekibele, CO, A Baiyeroju . "Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft". Afribary, Afribary, 20 Mar. 2021. Web. 04 May. 2024. < https://afribary.com/works/pterygium-treatment-using-5-fu-as-adjuvant-treatment-compared-to-conjunctiva-autograft >.
Bekibele, CO and Baiyeroju, A . "Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft" Afribary (2021). Accessed May 04, 2024. https://afribary.com/works/pterygium-treatment-using-5-fu-as-adjuvant-treatment-compared-to-conjunctiva-autograft