Quantization of Hemoglobin Types among sickle Cell Anemia Patients Attending Medical Army Hospital in Khartoum State

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This is prospective, analytical and cross- sectional study carried out in Medical Army hospital in Khartoum State, during April 2015 - July 2015. Forty sickle cell disease patients were studied, 18 were males and 22 were females, their ages 1-13 years, 23(58%) were sickle cell anemia (HbSS), 17(42%) were sickle cell trait (HbAS) as known cases by hemoglobin electrophoresis. The aim of this study to measure the level different hemoglobin types in the study group and comparison of this hemoglobin types in both homozygote and heterozygote states of sickle cell disease patients. Estimation hemoglobin types were carried out by CAPILLARYS 2 FLEX PIERCING instrument and the results were analyzed by SPSS computer

programme. The result revealed that the level of HbF in sickle cell disease patients is (7.2 ± 4.9) where as the level of HbA ,HbA2 and HbS were )78.5 ± 19.2), (3.1± 0.64) and (11.2 ± 21.5). The level of HbS is the higher indicate that most patients have large level of HbS which is the diagnostic hemoglobin for sickle cell anemia. The mean of HbF is increased because all patients given hydroxyurea and other supportive treatment. HbA2 show normal value, while HbA is decreased. HbF, HbS, HbA2 and HbA (%) show different means and std Deviations in males and females as HbF % in males (6.3 ± 3.5) while in females (8.1± 5.7), HbS % inmales (75.4 ± 24.6) while in females (80.9 ± 13.3), HbA2 (%) in males (3.3 ± 0.66) while in females (2.9 ± 0.60) and HbA (%) in males (14.9 ± 27.5) while in females (8.2 ± 15.0).

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Quantization of Hemoglobin Types among sickle Cell Anemia Patients Attending Medical Army Hospital in Khartoum State

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