Sex Differences in the Efficacy of Anti Malaria Drugs and Related Changes in the Haemoglobin Levels of Children under Five in Ghana

ABSTRACT

Background: One of the consequences of drug resistance to malaria parasites, is poor haematological recovery (Bloland et al., 1993; Verhoeff et al., 1997; Ekvall et al., 1998). Use of the right antimalarial is the key to avert this situation. Few studies have explored sex differences of these drug interventions in pediatric populations. ( Domellöf  M et al 2002 and Songül S et al 2009). Methods: This study is a descriptive study analyzing secondary data collected from a primary comparative efficacy study of four antimalarials in Ghanaian children under five in 2005. Age, sex, haemoglobin levels, parasite counts and temperature between sexes were used for the analysis. Pearson Chi square test, ANOVA and paired t-test were performed between sexes and day of treatment. Comparison of means, standard deviation, risk difference and mean difference were done where it applies stating p values of