ABSTRACT
The syntheses of benzoxazinophenothiazine was thoroughly explored. Condensation of 2,3-dichloro-1,4-naphthoquinone with 2-amino-4-nitrophenol, 4,5-diamino-6-hydroxypyrimidin-2-thiol and 2-amino-6-chlorophenol, respectively in alkaline medium yielded the intermediates: chloro-10-nitrobenzo[a]phenoxazin-5-one(136), 11-amino-6-chloro-9-thiol-8,9-diazabenzo[a]phenoxazin-5-one (148) and 6,8-dichlorobenzo[a]phenoxazin-5-one (160). Further
treatment of the intermediates with 2-aminothiophenol and 3-amino-6-methoxypyridin-2-thiol gave the complex derivatives: 14-nitrobenzo[a][1,4]benzoxazino[3,2-c]phenothiazine (137), 15- amino-13-thiol-12,14-diazabenzo[a][1,4]benzoxazino[3,2 c]phenothiazine (149) and 12-chloro-9-methoxy-8-azabenzo[a][1,4]benzoxazino[3,2-c]phenothiazine (161). The compounds were characterized by UV/Visible, FT-IR, (1H and 13C-NMR) spectroscopy and elemental analysis. The synthesized compounds were screened against eight (8) micro-organisms viz: Bacillus subtilis, Bacillus cereus, Staphylococcus aureus,Pseudomonas aeruginosa, Escherichia coli,
Kebsiella pneumonia, Asperigellus niger and Candida albicans using agar-cup diffusion method.
The results showed that the complex derivatives were significantly active against the microorganisms when compared to anti-bacterial and anti-fungal drugs
, I & CHRISTIAN, O (2021). Synthesis And Antimicrobial Activity Of Branched Benzoxazinophenothiazines And Their Derivatives. Afribary. Retrieved from https://afribary.com/works/synthesis-and-antimicrobial-activity-of-branched-benzoxazinophenothiazines-and-their-derivatives
, IKE and OZOEMENA CHRISTIAN "Synthesis And Antimicrobial Activity Of Branched Benzoxazinophenothiazines And Their Derivatives" Afribary. Afribary, 21 May. 2021, https://afribary.com/works/synthesis-and-antimicrobial-activity-of-branched-benzoxazinophenothiazines-and-their-derivatives. Accessed 19 May. 2024.
, IKE, OZOEMENA CHRISTIAN . "Synthesis And Antimicrobial Activity Of Branched Benzoxazinophenothiazines And Their Derivatives". Afribary, Afribary, 21 May. 2021. Web. 19 May. 2024. < https://afribary.com/works/synthesis-and-antimicrobial-activity-of-branched-benzoxazinophenothiazines-and-their-derivatives >.
, IKE and CHRISTIAN, OZOEMENA . "Synthesis And Antimicrobial Activity Of Branched Benzoxazinophenothiazines And Their Derivatives" Afribary (2021). Accessed May 19, 2024. https://afribary.com/works/synthesis-and-antimicrobial-activity-of-branched-benzoxazinophenothiazines-and-their-derivatives