ABSTRACT
Human immunodeficiency virus-1(HIV-1) and hepatitis C virus (HCV) co-infection are two rapidly growing epidemics and health concerns strongly driven by injection drug use (IDU) in Kenya and the entire world. Inflammatory cytokines are important mediators of the host response to HIV-1 and HCV infections including injection drugs. However, the molecular interaction between HIV-1 and HCV co-infection and correlation with injection drug use is largely undefined. Therefore, this cross-sectional study determined plasma levels of interferon (IFN)-, interleukin (IL)-10, adiponectin and their association with CD4+ T cell count, HIV-1 viral load and basal metabolic index (BMI) in HIV-1 and HCV mono-infected antiretroviral (ART)-naive (n=18) and -exposed (n=38); and co-infected ART-naive (n=5) and -exposed (n=14); and uninfected (n=24) IDUs and healthy controls (n=27). One hundred and thirty five injection drug users and 27 healthy controls were recruited from Bomu Medical Center, Mombasa, Kenya through outreach and respondent driven sampling methods. Social demographic information including drug use histories were collected from the study subjects upon enrolment into the study through structured interview schedules with open- and closed-ended questions. Plasma cytokines levels were determined using Enzyme linked Immunosorbent assay (ELISA) technique, CD4 T cell count were enumerated using FacsCaliburTM flow cytometry, HIV-1 viral load through polymerase chain reaction (PCR), and HIV-1 and HCV infections determined by rapid sero-diagnosis. Interferon (IFN)- levels differed across-group (P
KARANJA, J (2021). Cytokines Levels And Their Relationship With Clinical Correlates In Human Immunodeficiency Virus/Hepatitis C Co-Infected Drug Users From Mombasa County, Kenya. Afribary. Retrieved from https://afribary.com/works/cytokines-levels-and-their-relationship-with-clinical-correlates-in-human-immunodeficiency-virus-hepatitis-c-co-infected-drug-users-from-mombasa-county-kenya
KARANJA, JOSEPH "Cytokines Levels And Their Relationship With Clinical Correlates In Human Immunodeficiency Virus/Hepatitis C Co-Infected Drug Users From Mombasa County, Kenya" Afribary. Afribary, 31 May. 2021, https://afribary.com/works/cytokines-levels-and-their-relationship-with-clinical-correlates-in-human-immunodeficiency-virus-hepatitis-c-co-infected-drug-users-from-mombasa-county-kenya. Accessed 22 Nov. 2024.
KARANJA, JOSEPH . "Cytokines Levels And Their Relationship With Clinical Correlates In Human Immunodeficiency Virus/Hepatitis C Co-Infected Drug Users From Mombasa County, Kenya". Afribary, Afribary, 31 May. 2021. Web. 22 Nov. 2024. < https://afribary.com/works/cytokines-levels-and-their-relationship-with-clinical-correlates-in-human-immunodeficiency-virus-hepatitis-c-co-infected-drug-users-from-mombasa-county-kenya >.
KARANJA, JOSEPH . "Cytokines Levels And Their Relationship With Clinical Correlates In Human Immunodeficiency Virus/Hepatitis C Co-Infected Drug Users From Mombasa County, Kenya" Afribary (2021). Accessed November 22, 2024. https://afribary.com/works/cytokines-levels-and-their-relationship-with-clinical-correlates-in-human-immunodeficiency-virus-hepatitis-c-co-infected-drug-users-from-mombasa-county-kenya