ABSTRACT
The metabolism of Paracetamol has been studied in Isoniazid pretreated albino rats and compared
with control. During this study, thirty-five (35) laboratory albino rats were used divided into five (5)
groups of seven (7) rats each. Group I served as control and the rats were only administered with
120mg/5ml/kg body weight dose of Paracetamol interperitoneally. However, Groups II-V served
as test groups and the members were pretreated with 10mg/kg body weight dose of Isoniazid
interperitoneally. Rats in group II were pretreated with the drug for 1 day, group III for 2days,
group IV for 3 days and finally group V received 4 days pretreatment. Moreover, pretreated groups
were also administered with 120mg/5ml/kg body weight dose of Paracetamol 24hours after each
pretreatment day(s). The mean serum Paracetamol concentrations were determined after each
pretreatment day(s) and compared with control. Therefore, the result of this work revealed a
significant increase (P
Ibrahim, L., , 1 , , I , , 2 , , 3 & 3Kabara, A (2018). EFFECT OF ISONIAZID ON THE METABOLISM OF PARACETAMOL IN RATS. Afribary. Retrieved from https://afribary.com/works/effect-of-isoniazid-on-the-metabolism-of-paracetamol-in-rats
Ibrahim, Labaran, et. al. "EFFECT OF ISONIAZID ON THE METABOLISM OF PARACETAMOL IN RATS" Afribary. Afribary, 11 Nov. 2018, https://afribary.com/works/effect-of-isoniazid-on-the-metabolism-of-paracetamol-in-rats. Accessed 19 May. 2024.
Ibrahim, Labaran, 1Labaran , I. , 2Lawan , 3Wudil and A.M. 3Kabara . "EFFECT OF ISONIAZID ON THE METABOLISM OF PARACETAMOL IN RATS". Afribary, Afribary, 11 Nov. 2018. Web. 19 May. 2024. < https://afribary.com/works/effect-of-isoniazid-on-the-metabolism-of-paracetamol-in-rats >.
Ibrahim, Labaran, 1Labaran , I. , 2Lawan , 3Wudil and A.M. 3Kabara . "EFFECT OF ISONIAZID ON THE METABOLISM OF PARACETAMOL IN RATS" Afribary (2018). Accessed May 19, 2024. https://afribary.com/works/effect-of-isoniazid-on-the-metabolism-of-paracetamol-in-rats