The growing number of diabetes coupled with the harsh side effects of some synthetic drugs has led to the increasing search for alternativeswhich are relatively cheap with minimal side effects. This study sought to investigate the antidiabetic effect of ethanolic extract of Carica papaya leavesin alloxan-induced diabetic rats. Thirty adult male albino rats were induced intraperitoneally with alloxan. The rats were grouped into six groups offive animals per group: Group A was not induced with ...
Background: The search for newer sources of antibiotics is a global challenge pre-occupyingresearch institutions, pharmaceutical companies and academia, since many infectious agents arebecoming resistant to synthetic drugs.Aim: This present study sought to investigate the antibacterial potential of ethanolic and aqueousextracts of Carica papaya leaves.Materials and Methods: Fresh and healthy leaves of C. papaya were harvested, air dried andmilled into powder. The powder was extracted using et...
There is a general believe that bitter kola isan aphrodisiac agent, thus men consume it to enhancetheir libido. This study is aimed at assessing theeffect of bitter kola on male sex hormones. Twentyfour adult male Wistar rats were randomly dividedinto four groups of six each after seven daysacclimatization period. Animals in group 1 wereadministered normal saline solution while those ingroups 2, 3 and 4 were administered 100, 200 and400 mg/kg body weight of bitter kola extractsrespectively fo...
This study is aimed at evaluating theameliorative effect of Parkia biglobosa againstegg-yolk induced hypertension. In order toachieve this, 30 Wistar rats were divided intothree groups of 10 each. Rats in group Areceived normal feed diet and they served as thecontrol group while those in groups B and Creceived a special prepared egg feed diet (24 eggyolk mixed with 1 kg of normal rat diet).Animals in group C were administered400mg/kg body weight of P. biglobosa extractsimultaneously with the ...
The presence study aimed to investigate the phytochemical and heavy metals level in selected vegetables grown in Kalambaina area ,the phytochemical were determined using analytical methods and the heavy metals (Cd, Pb, Zn, Ni, Cr and Cu) concentration in vegetables and water were determined using atomic absorption spectroscopy (AAS). The study indicate the presence of flavanoid, alkaloids, steroids, volatile oil, saponin glycosides in all the vegetables. The concentration of copper was found ...
ABSRACT Chlorpyrifos [CPF; O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothionate] is a widely used organophosphate pesticide that is known to be toxic to the environment and to living beings. It affects several organs of the body especially the brain leading to impairment of normal functioning of the body. Diphenyl diselenide (DPDS), an organsoselenium compound is the simplest of the synthetic diaryldiselenides. Studies have shown that DPDS exhibits anti-inflammatory and antioxidant e...
INTRODUCTION Oxygen is an indispensable element for life. Oxidative property of oxygen plays a vital role in various biological phenomena; being essential for life, oxygen can also aggravate the damage within the cell by oxidative events. Oxygen is used by the cell to generate energy and free radicals are formed as a consequence of ATP (adenosine triphosphate) production by the mitochondria. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are the by-products resulting from t...
ABSTRACT The neuromuscular junction (NMJ) is a unique, specialized chemical synapse that plays a crucial role in transmitting and amplifying information from spinal motor neurons to skeletal muscles. NMJ complexity ensures closely intertwined interactions between numerous synaptic vesicles, signaling molecules, ion channels, motor neurons, glia, and muscle fibers, making it difficult to dissect the underlying mechanisms and factors affecting neuro-degeneration and muscle loss. Muscle fiber...
Parkinson’s disease is a degenerative neurological disease, which is characterized by the preferential death of dopaminergic neurons in the Substantia Nigra. Current drug treatments are aimed primarily for the treatment of symptoms to improve the quality of life. Therefore, there is a need to find out new therapeutic strategies that not only provide relief but also halt or reverse the neuronal damage hampering PD progression, thus this research therefore aimed at investigating the impact o...
ABSTRACT The place of adequate nutrition in the live of the young especially in the recently weaned cannot be overemphasized. The abrupt change in diet, leading to possible immune system weakness and disease conditions, is a focal point in the care of the young. This project examined serum globulin and bilirubin levels in weanling rats whose feed was supplemented with Emilia sonchifolia leaf extract.Present investigation were carried out on the effect of ethanolic extract of Emilia Sonchifo...
The overall objective of this study is to scientifically evaluate the claimed fertility enhancing potential and to assess the metabolic effect of the ethanolic extract of Sphenocentrum jollyanum pierre (Menispermaceae) root using male wistar rats as model. The specific objectives include the following · To determine the proximate and phytochemical composition of the ethanolic extract of Sphenocentrum jollyanum (root) this will justify the ethno pharmacological use of th...
ABSTRACT The present study investigated the effects of a 2-week swimming exercise on scopolamine-induced dementia in a mice model. Thirty-two mice, were randomly divided into four groups (8 rats in each). Group A served as control without exercise and received saline only; Group B served as induced control and receive a single dose of scopolamine (1 mg/kg, i.p.) only on the last day; group C mice were subjected to short-term exercise (swimming) + single dose of scopolamine (1 mg/kg, i.p.) on ...
ABSTRACT Ginkgo biloba (GB) leaves and extracts have been recognized worldwide for its renowned nutritional and medicinal properties. GB tree is highly grown and used in Asian and South American countries unlike Nigeria. In this study, we examined the nutritional and anti-nutritional compositions of GB leaves (whole dried, and aqueous and ethanol extracts) grown in Nigeria. Association of Official Analytical Chemists (AOAC) method was used to determine the proximate and vitamin compositions w...
Citrullus lanatus (water melon) is a commonly consumed fruit worldwide. The seeds are often thrown away without considering its potential nutritional and medicinal benefits. In this study, a methanol extract of citrullus lanatus seeds was analyzed for the presence of bioactive secondary metabolites and to determine its ability to scavenge 2, 2‐ diphenyl ‐1‐ picrylhydrazyl (DPPH.) radical, superoxide anion radical (O2.‐), and nitric oxide radical (NO.). Quantitative phytochemical a...
Docking is a structure-based technique which attempts to find the “best” match, between two molecules. Molecular docking can be thought of as a problem of “lock-and-key”, in which one wants to find the correct relative orientation of the “key” which will open up the “lock” (where on the surface of the lock is the key hole, which direction to turn the key after it is inserted, etc.). The explosion of structural informatics, genomics and proteomic plays a major role in leading t...