EFFECT OF FOOD CHAIN MEDIATED CHRONIC EXPOSURE TO ARSENIC AND CADMIUM ON REDUCED GLUTATHIONE (GSH) AND GLUTATHIONE S￾TRANSFERASE (GST) LEVELS IN THE BRAIN OF ALBINO RAT (WISTAR RAT)

ABSTRACT
The study aims to evaluate the effect of food chain mediated chronic exposure to arsenic and 
cadmium (singly and combined) on the level of reduced glutathione (GSH) and the activity of 
glutathione S-transferase (GST) in brains of rats. Fortymale Wistaralbino rats were fed with a diet 
containing fish fed with normal feed in water contaminated with 0.4 mg/100 ml cadmium (group B), 
arsenic (group C) and cadmium + arsenic (group D) respectively for three months. The control rats 
were fed with diet containing non-metal exposed fish. At the end of the experimental period, the rats 
were sacrificed; brains were harvested and centrifuged to get the supernatant which were used for 
biochemical assay of reduced glutathione (GSH) and glutathione S-transferase (GST) within 24 hours. 
There was a significant decrease (p