ABSTRACT
Targeting apoptosisisan attractive approach in cancertherapy. Induction of apoptosis can be carried out by the BH3-only proteins of the BCL-2 family(having only the BCL-2 homology domain BH3) by binding to the pro-survival members and neutralizing their functional activity (sequestration of the pro-apoptotic Bcl-2 family members).
In this review, brief summary of the current models of Bcl-2 family function and the work demonstrating the influence of deregulated Bcl-2 family member expression on tumorigenesis and cancer therapy was done. Possible implications of the additional role of the expression of Bcl-2 family members in tumor cells, as it influence apoptotic behavior, and impinge on cell cycle was also discussed.
Olagunju, A. (2018). Molecular Mechanism of Carcinogenesis-Review Article. Afribary. Retrieved from https://afribary.com/works/molecular-mechanism-of-carcinogenesis-review-article
Olagunju, Abolaji "Molecular Mechanism of Carcinogenesis-Review Article" Afribary. Afribary, 12 Mar. 2018, https://afribary.com/works/molecular-mechanism-of-carcinogenesis-review-article. Accessed 07 May. 2024.
Olagunju, Abolaji . "Molecular Mechanism of Carcinogenesis-Review Article". Afribary, Afribary, 12 Mar. 2018. Web. 07 May. 2024. < https://afribary.com/works/molecular-mechanism-of-carcinogenesis-review-article >.
Olagunju, Abolaji . "Molecular Mechanism of Carcinogenesis-Review Article" Afribary (2018). Accessed May 07, 2024. https://afribary.com/works/molecular-mechanism-of-carcinogenesis-review-article