ABSTRACT
Starch is a naturally occurring polymer found in parts of the plants such as
leaves, stems, tubers, and fruits. It is a commonly used excipient in
pharmaceutical formulations because of its availability, affordability and
inertness. Cyperus esculentus (tiger nut) is widely cultivated in the country
especially in the northern part of Nigeria. Until recently, the use of tiger nut had
been limited to food products and few pharmaceutical applications. This
research is aimed at characterizing the starch isolated from Cyperus esculentus
tubers, ascertaining its use as a binder and disintegrant in paracetamol tablet
formulations, and to compare it with corn starch BP. Cyperus esculentus tubers,
paracetamol powder, corn starch, gelatin, talc, magnesium stearate, and sodium
benzoate were used for the study. Starch was isolated from Cyperus esculentus
tubers. Physicochemical tests such as determination of densities, viscosity, pH,
ash value, loss on drying, paste clarity, freeze thaw stability, browning and
charring temperatures were done on the starch. Wet granulation method of
tablet formulation was used to prepare paracetamol granules. The granules
produced were characterized and then compressed into tablets. The formulated
tablets were evaluated for various tablet properties such as hardness, thickness,
friability, weight variation, disintegration time, dissolution rate as quality
control measures. The physicochemical properties of starch from Cyperus
esculentus were found to conform to BP standards for pharmaceutical grade
starch. Results obtained from micromeritic studies such as angle of repose of
58.74 o, compressibility index of 16.0 % and Hausner’s quotient of 1.19
revealed that Cyperus esculentus is a poorly flowing powder. Paracetamol
granules produced had good flowability as shown by angle of repose being
< 50 o, Hausner’s quotient of
CHINWEOLU, O (2021). Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets. Afribary. Retrieved from https://afribary.com/works/preformulation-studies-of-cyperus-esculentus-starch-used-as-disintegrant-and-as-binder-in-the-production-of-paracetamol-tablets-1
CHINWEOLU, OKWUCHUKWU-MADUKA "Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets" Afribary. Afribary, 14 May. 2021, https://afribary.com/works/preformulation-studies-of-cyperus-esculentus-starch-used-as-disintegrant-and-as-binder-in-the-production-of-paracetamol-tablets-1. Accessed 22 Nov. 2024.
CHINWEOLU, OKWUCHUKWU-MADUKA . "Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets". Afribary, Afribary, 14 May. 2021. Web. 22 Nov. 2024. < https://afribary.com/works/preformulation-studies-of-cyperus-esculentus-starch-used-as-disintegrant-and-as-binder-in-the-production-of-paracetamol-tablets-1 >.
CHINWEOLU, OKWUCHUKWU-MADUKA . "Preformulation Studies Of Cyperus Esculentus Starch Used As Disintegrant And As Binder In The Production Of Paracetamol Tablets" Afribary (2021). Accessed November 22, 2024. https://afribary.com/works/preformulation-studies-of-cyperus-esculentus-starch-used-as-disintegrant-and-as-binder-in-the-production-of-paracetamol-tablets-1