ABSTRACT Leishmaniasis is widely considered among neglected tropical disease and threatens about 350 million people globally. In spite of advances in drug discovery, high toxicity, and drug resistance limits current drugs. With current emphasizes on use of medicinal plants worldwide, three novel tetracyclic iridoids, Molucidin, ML-2-3 and ML-F52 were identified from Morinda lucida, a medicinal plant, to have anti-trypanosomal activity. This study sought to determine the activity of irido...
ABSTRACT Mycobacterium ulcerans’ mycolactone, is reported to mediate the production of ROS in keratinocytes; cells that play critical role in wound healing. The key stimulatory function of macrophages in the production of keratinocytes and fibroblasts during wound healing may also be impaired by mycolactone-mediated ROS. To ensure regeneration of tissues with proper and timely healing of the wounds, antioxidants that can combat the effects of ROS ought to be investigated. This study was the...
ABSTRACT Fault seal analysis in fault dependent reservoirs were carried out at different reservoir levels in the Baka Field, Niger Delta. These involved stratigraphic correlation, 3-D seismic interpretation of faults and horizons, time-depth conversion of all interpreted faults and structural maps using both check-shot and synthetic seismogram. Also, static models of all interpreted reservoir levels, and 3-D deterministic and stochastic fault seal integrity models were carried out. The deter...
SUMMARY An assessment of the fishery of five major commercial species which together contribute more than 70% of the catches in stratum VII (near Yeji) of the Lake Volta has been made based on studies undertaken between March, 1995 and December, 1996. The species studied are: Hemisynodontis membranaceus (Geoffroy St. Hilaire, 1809), Chrysichthys nigrodigitatus (Lacepede, 1809), Chrysichthys auratus (Geoffroy St. Hilaire, 1809), Oreochromis niloticus (Linne, 1757), and Schilbe intermedius (Rup...
ABSTRACT This study reports for the first time in Ghana long-term monitoring of heavy metal contamination of vegetables. As reliable residue data analysis resulting from monitoring programs in foods is of great value to the general populace; this could address the possible risk of heavy metal exposure to human health. In this study, monitoring of heavy metals (As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb and Zn) in consumable vegetables was assessed for a period of 2 years, 2013-2014. In all, a total o...
ABSTRACT In this work, the production of biogas from local biomass has been studied through the design, construction and operation of a single-stage, multi-feedstock anaerobic digester, with the aim of providing the scientific and technological bases for the mass assembly and deployment of modular and scalable bio-digester system, using components obtainable in Ghana. A horizontal cylindrical plastic tank (1 m3) with torispherical ends has been developed into an air-tight (sealed) anaerobic d...
ABSTRACT During radiotherapy, some accessories used gets into the path of the photon beams. These somehow attenuate the beam to some extent. Therefore it is imperative that every radiotherapy facility quantifies the degree by which these accessories attenuate the beams. This informs the facility operators on the necessary corrections to make to achieve the desired dose to the target area. The purpose of this study was to evaluate the attenuation effects of 6 MV and 15 MV photon beam by an iBe...
ABSTRACT This study is about community participation in the Primary Health Care programme in Akwapim North District. Twenty-four years have passed since Primary Health Care (PHC) was first introduced at the Alma-Ata conference. In 1985 the World Health Organization (WHO) completed a ‘Review of PHC’. Such evaluations have shown that many o f the problems o f the PHC are concerned with the management of PHC. An analysis of some of the management problems shows that they are deep seated and ...
ABSTRACT Introduction: Meningitis is one of the leading causes of death among patients living with HIV in sub-Saharan Africa. Based on clinical presentations, the different types of meningitis may not be distinguished from each other therefore, accurate laboratory diagnosis is extremely essential. Viruses such as Enteroviruses, Mumps virus and Herpes Simplex Virus-1 are implicated in cases of meningitis. Aim: The aim of the study was to determine the prevalence of viral meningitis among hospi...
ABSTRACT Some selected tropical root and stem tubers (cassava, cocoyam, sweet potato and yam) were dried and processed into flours. The cassava tuber was processed into flour using the high quality grading method. Bambara groundnut was processed to obtain the conventional bambara groundnut flour, bambara groundnut cotyledon flour and the steamed bambara groundnut cotyledon flour. Composite flours were formulated using each of the root tubers and each of the bambara groundnut treatments in th...
ABSTRACT The antimicrobial activities and preservative potentials of crude plant extracts of stem bark of Alstonia boonei, leaves of Euphorbia hirta and seeds of Moringa oleifera were studied. Soxhlet extraction method and cold ethanol extraction method were used for the extraction of the dried and ground plant samples. The well in agar diffusion method was used for the antibacterial screening at different concentrations of 25mg/ml, 50mg/ml, 100mg/ml and 200mg/ml on Eschericia coli, Bacillus...
ABSTRACT Cancer remains a killer disease worldwide and research into various anticancer agents must continue unabated to assuage the devastating effects of the disease. Medicinal plants have been utilised since antiquity to cure various ailments and plant species continue to serve as sources of prototypes for drug discovery. The study sought to screen Ghanaian traditional medicinal plants for their antiproliferative effect on MCF7 breast cancer cell line and determine the mechanism of inducti...
ABSTRACT “Internet banking” is a product offered by commercial banks to enable clients carry out banking transaction at their convenience and at any time. It enables banks to reduce operational cost by reducing the cost of stationary and also number of staff. However, clients of commercial banks in Ghana still prefer conducting transaction at the branches of the banks rather than signing on to internet banking. This is evident in the queues by clients in commercial banks in order to carry...
ABSTRACT The effects of water and methanol extracts of 19 Ghanaian plants belonging to 12 families on some aspects of the physiology of five fungi (Scopulariopsis brevicaulis, Aspergillus niger, A. flavus, Sclerotium rolfsii, Nigrospora sp.), and five bacterial species (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella (Group C,), Escherichia coli (EPEC 0:43), E. coli (ETEC OK5)) were investigated in vitro in either liquid or agar medium amended with varying dilutions (1:1 - 1:5 v/v)...
Abstract Schistosomiasis is the second most prevalent parasitic infection apart from malaria. Unlike the latter, whose prevalence tends to fluctuate with the rains in many areas of high endemicity for the year, schistosome infection prevalence may be usually high throughout the year in areas where the disease is endemic. Available WHO(1991) document indicates that the disease afflicts more than 200million people while 500-600million are considered to be at risk of infection in 76 countries. F...