Street vended foods are the major source of food borne diseases in most parts of sub-Saharan Africa including Nigeria. In this study, six samples each of six different vended foods obtained in Calabar municipality were evaluated for bacteriological quality and presence of Staphylococcus aureususing standard microbiological techniques. Each food was examined macroscopically for evidence of spoilage, followed by culture isolation for Staphylococcus aureus. The organisms isolated were subjected ...
Extracts of J. gossypifolia L. have been reported to have several medicinal values, including potential anti-cancer and anti-inflammatory properties. In this study, we investigated the anti-clastogenic and hepatoprotective, effects of the ethanolic leaf extract of J. gossypifolia L. in potassium bromate (KBrO3)-induced toxicity in rats. The general trend of the results indicates significant increases (p
We evaluated the brain, lung, and heart oxidative stress in rats exposed to aerosol of an over-thecounter pyrethroid insecticide product in Nigeria. The experimental animals were randomly divided into four groups: group I (control) was not exposed to the insecticide aerosol, while groups II, III, and IV were exposed to 6.0 mL m-3, 12.0 mL m-3, and 18 mL m-3 of insecticide ae...
Background: The current upsurge in the use of polyherbal remedies and coupled with loose regulation on public access to these products underscore research efforts to evaluate their biochemical effect, noting also that many of the polyherbal medicines lack scientific evidence to support their medicinal claims. Objective: We therefore investigated the potential genotoxicity, hematotoxicity and ...
Extra-pulmonary oxidative stress investigations of exposure to aerosol, of an over-the-counter pyrethroid insecticide product in Nigeria in Wistar rats were carried out. Four groups of five animals each were used in this study, and were exposed to different concentrations of the insecticide aerosol. Malondialdehyde (MDA) and reduced glutathione (GSH) concentrations were determined in the live...
Introduction: Raw edible camphor (EC), and as component of herbal infusions are widely used to treat pile, back pain, erectile dysfunction, and as an aphrodisiac especially in preparation for sexual intercourse by men. It has been traced in umbilical cord, blood, fetal, adipose, and other tissues including brain, where it bioaccumulates. Methods: The study, therefore, investigated the possible histopathological changes in brain, heart, and spleen that may result following ...
Increasing environmental pollution in the tropics is creating a breeding ground for mosquitoes, leading to increasingly frequent use of insecticides to combat home infestation of mosquitoes, the vector of malarial parasites. Household members are therefore more prone to aerosol exposure and subsequent health effects. We assessed the hepatotoxic and clastogenic effects in rats exposed to different levels of aerosols of one of the insecticides most commonly in used in Nigeria. There were signif...
Ginger or Zingiber officinale has been reported to possess antioxidant activities that can protect against free radical damage. We therefore carried out this study to investigate the possible ameliorative effects of ginger against the clastogenicity, hepatotoxicity and oxidative stress induced by nitrobenzene (NB) administration in wistar rats. Twenty male wistar rats were divided into four g...
One interesting branch of biochemistry which scientists are still trying to completely unravel is the area of chronobiochemistry. The history of chronobiology is dated 400 B.C., when Androsthenes observes that leaves of certain trees open during the day and close at night. It was only recently that the first human clock gene was discovered. All living organisms possess an internal bio...
ABSTRACT Background: Edible camphor (EC) is one of the ingredients in the preparation of local infusion for the management and treatment of pile, back pain, and erectile dysfunction, which are practices commonly in the south-western part of Nigeria. Methods: Thirty rats were used for the study, and were divided into six groups of five rats each. Group I animals served as normal ...
In living cells, especially eukaryotes, mitochondria involvement appears to be important in the general status of every aspect of life. Apoptosis as a programmed cell death is mandatory to all life process thus, mitochondria might be describe as organelles that serves as a gatekeeper to trap a variety of proapototic protein and prevent the functions of this proteins in the cytosol...
The purpose of this research work is to isolate and identify Using ID 32C API kit and to determine the antifungal sensitivity profile of fungi isolated from the mother and child dump site Akure, Ondo state, Nigeria. Ten isolates (Yeast, Aspergiliusflavus, Aspergiliusniger, Fusariumsolani, Candida albucan, Candida kruise, Phytoptera, Rhizopusstolonifer, Trichodermhorizianum,Fusariumvortezelium) were used for this research work.Potato Dextrose Agar was used to isolate and prepared for enume...
This work was carried out to evaluate the antibacterial and Phytochemical activities of Caesalpiniapulcherrima leaf and stem bark on some clinical isolates. The plant parts were collected from St. Benedict Catholic Church premises, Owena Barracks, Akure, Ondo State. Crude ethyl acetate extracts of Caesalpinia pulcherrima leaves and stem bark was assayed for its antibacterial activity against Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa, Bacillus subtilis, Escheric...
Abstract Essential oils (EO), according to the International Standard Organization (ISO) defines essential oil as the product obtained from parts of plants by distillation with water steam and the product obtained by expression from pericarp of medicinal plant. The rapid growth and increase of the knowledge of identification, extraction, purification and characterization of essential oils in most local plant species is fast becoming an important aspect of the drug production process. ...
Abstract This study evaluated the antimicrobial activity, of Alstonia boonei leaf, stem bark and the synergistic efficacy of A. boonei leaf plus stem bark on seven bacteria (Gram positive and Gram negative bacteria) which are strains of Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Proteus viridans, Salmonella typhi and Klebsiella pneumoniae, and three fungal isolates which are Candida albicans, Aspergillus flavus and Trichophyton rubrum. This study also ...