ABSTRACT This study was conducted to determine the prevalence of ESBL-producing enterobacteria in chickens and cattle slaughtered at Ikpa market, Nsukka; to identify the types of ESBL enzymes harboured by the ESBL-producing bacteria isolates and to determine the antibacterial résistance phenotype and genotype of the ESBL-producing isolates. This study adopted a survey design. It was conducted at Ikpa market, Nsukka, Enugu State Nigeria. The market was purposively selected because it is a ma...
Abstract This study evaluated the use of the methanolic leaf extract of Palisota hirsuta in postsurgical wound management using different wound models in rats. It also assessed the antibacterial activity of the plant extract as well as the possible toxic effects on the liver, kidney and blood. The yield of the methanolic leaf extract of Palisota hirsuta (PHLE) was 5.98 % w/w and it was dark green, pasty in consistency with a pungent smell. In the excision wound model, PHLE at 1% and 4 % sign...
ABSTRACT This study was conducted to document the occurrence and characteristics of mycotic agents isolated from trade horses and donkeys in Obollo-Afor, Enugu State. A total of 497 horses and 65 donkeys presented for sale at Obollo-Afor horse/donkey market during the wet season (June to August 2014) and dry season (January to March 2015) were examined for skin lesions. For each horse/donkey examined, the location of skin lesion as well as the sex of the animal was recorded. Each skin lesion...
ABSTRACT The high turn-over rate and quest for white meat have given more impetus to poultry production. The need to increase production and meet the demand for poultry meat has necessitated the use of veterinary drugs, especially antimicrobials, for therapeutic, prophylactic and growth promotion purposes in poultry farming. These drugs tend to accumulate in tissues and organs as residues. The presence of drug residues in tissues above the maximum residue limit (MRL) becomes violative if wit...
ABSTRACT The methanolic root bark extract of Afzelia Africana was tested for antidiabetic activities in-vivo. The acute toxicity of the extract was tested in mice and the result showed that the extract 6 has low toxicity. Investigation on the phytochemical constituents of the plant extract revealed the presence of flavonoids, tannins, alkaloids, steroids and saponins. The plant extract was tested for antidiabetic activities in alloxan-induced diabetic mice at doses; 62.5 mg/kg, 125 mg/kg, 25...
ABSTRACT Effect of stabilizing chloroquine phosphate in a synthetic Aluminium Magnesium silicate (Nanoparticles) on the antiplasmodial activity of the drug was investigated. Mice infected with Plasmodium berghei were treated with chloroquine phosphate at 7 mg/kg, 5 mg/kg and 3 mg/kg dose levels respectively. Two subgroups at each dose level were treated with chloroquine phosphate alone and with a drug formulation of 20% chloroquine phosphate in the synthetic Aluminium Magnesium Silicate (AMS...
ABSTRACT Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. It is a growing public health concern worldwide affecting humans and animals. Synthetic drugs available for the treatment of the ailment have serious side effects, complicated mode of intake and are costly. Literature search revealed that Cussonia arborea is used folklorically in the management of Diabetes mellitus....
ABSTRACT This study was carried out to evaluate the chemical composition and bacterial load of donkey meat as well as the prevalence of verotoxigenic Escherichia coli (VTEC). The study adopted the survey and experimental designs. A questionnaire, which comprised three sections, was developed to elicit information on the demographics, source of meat, and factors that influence choice of meat consumed by the respondents. The instrument for data collection was validated by three experts. A pilo...
ABSTRACT The contractile activity of M. pruriens and the relaxatory property of C. odorata was investigated using in vitro methods in the rat. M. pruriens caused a dose-dependent increase in uterine muscle contraction with a maximum peak in amplitude with 0.57 mg/ml of the extract and an EC50 of 2.7 mg/ml. The contraction was unaffected by atropine sulphate (0.042 µmol), but abolished by isoprenaline (0.06-0.23 µmol), salbutamol (0.012-0.4 µmol) and adrenaline (16 nmol).Uterine muscle con...
ABSTRACT The fusion between the “breakpoint cluster region” gene (BCR) and Abelson gene (ABL1) is the molecular hallmark of most cases of chronic myeloid leukaemia and some cases of acute lymphoblastic leukaemia. The objective of this study was to detect BCR-ABL1 in saliva of known CML patients collected in Oragene-RNA kit (DNA Genotek, Canada) and to see if mRNA could be preserved for a longer period in the saliva samples than in blood samples. A comparison of the BCR-ABL ratios in bloo...
ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered through the oral route. Rectal administration, which formed the basis of this work, is an alternative route of administration which overcomes the lim...
ABSTRACT This study was designed to assess the knowledge, attitude and adoption of appropriate infant feeding practices of mothers and the anthropometric indices of their children. Three hundred and seventy three mothers who attended infant welfare clinics at the three health settings (General hospital Ekwulobia, Primary health care Ekwulobia, and Primary health care Akpo) all in Aguata L.G.A were involved in the study. The study evaluated the nutritional status of the infants in relation to...
ABSTRACT This epidemiological study was to elicit information on the consumption pattern of antioxidant-rich foods among middle-aged adults in Enugu North local government area, Enugu State, Nigeria. Four hundred adult men and women aged 40-60 years were used for the study. Multiple- staged stratified random sampling technique was used for the selection of the subjects used for the study. The respondents were randomly selected from 10 streets in the 5 urban zones making up the Enugu North l...
ABSTRACT Reports show that most maternal deaths occur during the post natal period, yet this is when coverage and programmes of maternal and child health are at their lowest along the continuum of care in the local government, state, country and African region at large. Therefore it is important to investigate postnatal care practices carried out by mothers to reduce the trend. The aim of this is study was to assess postnatal care practices with respect to, perineal wound care, breast-feedin...
Abstract Fifty (50) Non-diabetic Hypertensive Patients in the medical out-patient (MOP) department of University of Nigeria Teaching Hospital (UNTH), Ituku Ozalla, Enugu, Nigeria aged 40-78 years comprising 25 males and 25 females were investigated. Also fifty age and sex-matched apparently healthy subjects served as the control group. The following variables were determined using standard methods: prothrombin Time, Activated partial Thromboplastin Time, Fibrinogen Assay, platelet Count, Fas...