ABSTRACT Most commercially available assays for diagnosis of HIV infection have shown shortcomings in the detection and quantification of rare genotypes of the virus. Most of the assays do not detect subtype O (outlier) and/or N (nonmajor, nonoutlier) or new circulating recombinant forms (CRFs), which are becoming more important in sub-Saharan Africa. Furthermore, the commonly available tests require costly measuring devices and expensive test kits, which are not easily affordable for develop...
ABSTRACT We compared the premorbid social adjustment of 38 schizophrenic patients with that of 20 manic patients. Even though the small sample size affected the number of significant differences obtained, schizophrenic patients consistently showed evidence of poorer premorbid functioning than manics at various stages of social development. Schizophrenic men also tended to have functioned more poorly than women. Poor premorbid functioning was associated with negative syndrome, but not with pos...
ABSTRACT The practice of early marriage has persisted in some Nigerian tribes, despite its associated negative health effects. There is however inadequate information on adolescents‟ knowledge and attitude towards this practice. This study was therefore conducted to determine knowledge, attitude and the prevalence of early marriage among adolescents in Sasa, a multi-ethnic community in Akinyele Local Government Area Nigeria. Using a three-stage sampling technique, 400 adolescents were rec...
ABSTRACT Records of 15 patients presenting with pressurised bottled drinks related eye injuries between January 1996 and 2001 were reviewed to identify factors contributing to accidental eye injuries from pressurised bottled drinks, reason for poor outcome and to make recommendations. In all, 16 eyes of 15 patients were studied out of which 7 were males (M:F, ratio I:1.1). Age range, 3 years-49 years, mean 23.6 years. The majority of those affected were students 46.7%, and traders 26.7%. The ...
ABSTRACT Background: A palliative care and Hospice service is a neglected aspect of medical discipline especially in a developing country like Nigeria. With the global increase in incidence of cancer and HIV/A IDS and 70% of them presenting late, coupled with limited resources, for effective symptom control, palliative care therefore remains the only option left to improve the quality of life of the patients Objective: To assess the, knowledge and attitudes of patients and their relations to...
ABSTRACT Objectives: This case-control study was done to determine the association and prevalence of p53 codon 249 mutation using cell-free DNA in the plasma of patients with hepatocellular carcinoma (HCC) in South-Western Nigeria. Method: Eighty-five adults with HCC and seventy-seven age and gender matched controls without evidence of liver disease or malignancy involving any part of the body, were recruited. Plasma DNA was analyzed for p53 codon 249 by restriction fragment length polymorphi...
ABSTRACT The concentration levels of selected heavy metals, (Cu, Cd, Zn, As and Cr) were determined in the soil (µg/g) and water (ppm) samples collected at Ikogosi Warm Spring, Ekiti State, Nigeria. After digestion, Atomic Absorption Spectrophotometer (AAS) was employed for the determination. The study area was at Latitude of 7o 35' 38.9'' , Longitude of 4o 58' 52.6'' and at average elevation of 479m above mean sea level (msl). The average concentrations (µg/g) of the heavy metals in the so...
ABSTRACT The amount of international biomedical research is increasing and much of this is happening in developing countries. It is important to place adequate focus on the issue of obtaining voluntary informed consent. Researchers need to understand local socio-cultural realities and also respect local cultural beliefs and indigenous research guidelines. Through examples from India, Iran and Nigeria the authors highlight the diversity within and between developing country situations. Emphasi...
ABSTRACT BACKGROUND: The aim of this study was to determine the sero-prevalence of Cag-A strains of Helicobacter pylori in both dyspeptic and nondyspeptic individuals and also correlate the serological status of Cag-A strain of H. pylori with the various graded histological variables of chronic gastritis in the dyspeptic patients.
ABSTRACT Use of Emergency Contraceptive Pills (ECP) is desirable in Nigeria where there is high rate of unwanted pregnancy. Pharmacists are expected to play important role in promoting use of ECP but few studies have assessed their knowledge, attitude and dispensing practice of this product in Nigeria. A total of 211 randomly selected pharmacists practicing in Ibadan and Lagos metropolis completed a questionnaire that assessed knowledge about ECP, attitude towards this contraceptive and actu...
Abstract Aims: This study aimed to describe the prevalence and pattern of lipid abnormalities among antiretroviral therapy (ART)- naive HIV patients, understand if there is any relationship to virologic and immunologic status, and discuss the implications for care. Methods: This was a cross-sectional study in which baseline demographic, clinical, and laboratory data of all ART-naive HIV-infected individuals recruited into the adult ARV clinic, University College Hospital, Ibadan, between Janu...
ABSTRACT Background: Magnetic resonance imaging (MRI), an advancement which followed computed tomography (CT) is expensive and inaccessible in most developing countries. However it is the procedure of choice in evaluating sellar and parasellar lesions. Its major advantages are its superior soft tissue contrast differentiation, its capacity for multiplanar imaging and nonexistence of ionising radiation. Its use is relatively new in Nigeria, a developing economy in Africa. Since its introductio...
ABSTRACT Drug-use pattern of anti-malarial has been associated with development of resistant strain and therapeutic failure. This descriptive cross-sectional study was carried out to assess anti-malarial drug-use practices among dwellers of Adigbe communities within Abeokuta environment. The study documented the knowledge, the attitude and behaviour of three hundred and fifty (350) respondents in terms of drug preference, attitude to drug use and the effects of non-compliance to antimalarial...
ABSTRACT Background: HIV-2 is comparatively less pathogenic with slow progression of infection to clinical disease and consequently there is less of information on the occurrence of HIV-2 associated disease than HIV-1. We hereby describe some laboratory profiles of individuals presenting with HIV-2 and dual HIV-1/2 related AIDS at the University College hospital in Ibadan over a period of seven years. Methodology: Blood samples from patients presenting with the AIDS defining illness at the U...
ABSTRACT Background: Pulmonary diseases are commonly seen in children with HIV infection, and their etioiogy is often' unclear. The-radioloqical appearances of these conditions are often non-specific. Conventional radiographs play an important role in the management of chest conditions especially in resource poor settings. Objective: This retrospective study was carried out to determine the chest radiographic pattern in children with HIV infection. Materials and Methods: The baseline chest X-...