Medical & Health Sciences

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Medical & Health Sciences Research Papers/Topics

MI Paste PLUS effect to prevent white spot lesions associated with orthodontic treatment [October 17, 2017]

Search result: Five contradicting clinical trials were found so far. Clinical outcomes: Some results show that MI Paste Plus appears more effective in reducing white spot lesions than placebo and fluoride varnish, while other results suggest that its effect appears to be equal to that of normal home care. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence ...

Etch-rinse systems with and without selective enamel etching [October 23, 2017]

Search result: 5 clinical trials were found. Clinical outcomes: The results indicate that additional selective enamel etching does not improve the clinical performance of restorations. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of resu...

Selective enamel etching effect on clinical performance of self-etch / self-adhesive systems [October 22, 2017]

Search result: 16 clinical trials were found. Clinical outcomes: Minor or no improvements are reported when selective enamel etching was used. Selective enamel etching may not pose a hazard in terms of postoperative hypersensitivity. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the asse...

Advantages of Self-etch versus Etch-and-rinse systems [October 21, 2017]

Search result: 10 articles reporting on 5 clinical trials after different follow-up periods were found. Clinical outcomes: The results indicate no difference in retention and anatomic form of restorations after 1 – 3 years. Marginal adaptation appears to be superior for etch-and-rinse systems after 1 – 2 years and no difference was found after 3 years. Marginal discoloration is significantly more observed for (1-step) self-etch systems. Post-operative sensitivity was the same for both ...

Resin infiltration to stop carious lesion progression [October 20, 2017]

Search result: 11 clinical studies were found. Clinical outcomes: The results suggest efficacy of resin-infiltration technique to stop caries progression and to improve aesthetic appearance of white spot lesions (WSL). However, discomfort levels appear to be higher than with other noninvasive interventions. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical eviden...

Anticaries effect of CPP-ACP [October 18, 2017]

Search result: As the topic of CPP-ACP is of high-priority a more intensive systematic literature search was conducted in order to produce this evidence sheet. 25 clinical studies were found. In-situ studies, as well as studies including ACP/casein materials not covered by the Recaldent technology, as included in the original systematic review, were not included. Clinical outcomes: The results regarding the clinical efficacy of CPP-ACP in the prevention and treatment of dental caries, i.e....

GIC versus RM-GIC as fissure sealant [October 16, 2017]

Search result: Only one clinical study was found. Clinical outcomes: The results indicate no difference in the caries preventive effect between both materials as fissure sealants in permanent teeth. The retention rate of RM-GIC in pits and fissures was higher than for conventional GIC. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in t...

Have stannous ions any remineralising effect on dental tissues? (Therapeutic) [November 22, 2016]

Search result: 2 trials were found. Clinical outcomes: The results of the laboratory trials suggest that stannous ions have a remineralising (therapeutic) effect on dental tissue (particularly when stannous fluoride was compared to sodium fluoride). The quality of the existing evidence requires further assessment. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical...

Have stannous ions any antibiotic effect on oral bacteria? [November 22, 2016]

Search result: 8 trials were found. Clinical outcomes: The results of the mainly laboratory trials suggest that stannous ions have an inhibiting effect on oral bacteria (particularly when stannous fluoride was compared to sodium fluoride). The quality of the existing evidence requires further assessment. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence ...

Has zinc any antibiotic effect on oral bacteria? [November 21, 2016]

Search result: 13 trials were found. Clinical outcomes: The results of the mainly laboratory trials suggest that zinc has an inhibiting effect on oral bacteria. The quality of the existing evidence requires further assessment. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment ...

What are the clinical merits of chemically cured glass-ionomers (GIC) for placing cervical tooth restorations? [November 21, 2016]

Search result: Only trials with low-viscosity GIC were found. The results suggest that cervical restorations placed with chemically cured GICs have good survival rates when compared to composite but are less aesthetic. Clinical outcomes: The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searche...

Potential of adverse effects due to aluminium, barium and strontium in GIC [November 19, 2016]

Search result: No clinical evidence concerning adverse effects of aluminium, barium or strontium released from glassionomer cements (GICs) were found. Clinical outcomes: A review of the relevant laboratory literature, including a conservative calculation of any potential adverse clinical effect due to aluminium content, concludes that the amount of aluminum that could be leached into the body from glass-ionomer dental fillings is well below the permitted daily dose and almost certainly too...

What are the clinical differences between HVGIC restorations placed after handmix or capsule mix? [November 19, 2016]

Search result: Three articles could be found. Clinical outcomes: Capsule mixed HVGIC (high-viscosity glass-ionomer cement) restorations appear to be superior to that of hand mixed. The quality of the existing evidence requires further assessment. The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systemati...

What is the failure rate of GIC restorations placed after incomplete removal of infected carious dentine? [November 18, 2016]

Search result: Two clinical controlled trials were found. Clinical outcomes: The results suggest no difference in the failure rate of GIC restorations placed after either complete or incomplete removal of infected (soft) carious dentin. The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches...

What is the recent evidence that merit composite resin for direct tooth restorations (as compared to amalgam as current gold standard)? [November 18, 2016]

Search result: Four clinical controlled trials were found between the period of 2004 and 2015 (19.11.15). Clinical outcomes: The results show that composite resin performs less satisfactory when compared to amalgam.The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental litera...


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