Natural & Applied Sciences

Research Papers/Topics Natural & Applied Sciences

Application of the Vector Autoregressive Model Incorporating New Measurements Using the Bayesian Approach

Abstract In this paper, an application of the updated vector autoregresive model incorporating new information or measurements is considered. We consider secondary data obtained from the Kenya National Bureau of statistics, Statistical Abstract reports from 2000-2021 which is on monetary value marketed at current prices from crops, horticulture, livestock and related products, fisheries and forestry. A VAR(1) model is fitted to the data and then the model updated to incorporate the measureme...

Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region

Abstract Plasmodium falciparum infections remain among the leading causes of morbidity and mortality in holoendemic transmission areas. Located within region 5q31.1, the colony-stimulating factor 2 gene (CSF2) encodes granulocyte–macrophage colony-stimulating factor (GM-CSF), a hematopoietic growth factor that mediates host immune responses. Since the effect of CSF2 variation on malaria pathogenesis remains unreported, we investigated the impact of two genetic variants in the 5q31.1 gene r...

Comparison of the Performance of Logistic Regression Model in the Presence and Absence of Mediation

Abstract Over the last decade major global efforts mounted to address the HIV epidemic has realized notable successes in combating the pandemic. Sub Saharan Africa (SSA) still remains a global epicenter of the disease, accounting for more than 70% of the global burden of infections. Despite wide spread use of various intervention strategies that act as mediation factors in Human Immunodeficiency Virus (HIV) prevention, HIV prevalence still remains a challenge especially in some geographic ar...

Bloodmeal host identities among sympatric Glossina austeni and Glossina pallidipes tsetse flies in Shimba Hills National Reserve, Kwale, Kenya

Abstract Odor from preferred/non-preferred tsetse fly vertebrate hosts have been exploited in R&D of attractants/repellents of the fly for human and livestock protection. Odors from vertebrate hosts of Glossina austeni and Glossina pallidipes tsetse flies can facilitate formulation of novel attractants effective against G. austeni or improvement of existing attractant blends for G. pallidipes. We compared vertebrate blood meal sources of both fly species at Shimba Hills National Reserve, Ken...

Evidence of Climate Change and Seasonal Agricultural Drought in Kakamega South Sub-County, Kakamega County, Kenya

Abstract Changes in climate have led to shifts in weather patterns outside the normal range of variation over a given time period, attributed to either human action or natural causes. This has led to reduced precipitation, which consequently results in reduced water availability for farming in some seasons, hence the seasonal agricultural drought. This has greatly impacted smallholder farmers, lowering their agricultural productivity. This study was undertaken in Kakamega South Sub-County in...

Queuing Model for Hospital Congestion with Application

Abstract The emergence of Covid-19 posed a great health challenge worldwide. Health care facilitieswere stretched beyond limit, with no space to admit new critical patients. This motivated thisstudy, which sought to understand the dynamics around queues, particularly in hospitals. Themain objective was to analyze the queuing process between the Emergency Department (ED)and Internal Wards (IW) at Moi Teaching and Referral Hospital, in order to understand patientflow with the view to minimizin...

Differential Gene Expression in Host Ubiquitination Processes in Childhood Malarial Anemia

Abstract Background: Malaria remains one of the leading global causes of childhood morbidity and mortality. In holoendemic Plasmodium falciparum transmission regions, such as western Kenya, severe malarial anemia [SMA, hemoglobin (Hb) < 6.0 g/dl] is the primary form of severe disease. Ubiquitination is essential for regulating intracellular processes involved in innate and adaptive immunity. Although dysregulation in ubiquitin molecular processes is central to the pathogenesis of multiple hu...

Evaluation of a pilot interprofessional train-the-trainer workshop to enhance sickle cell anemia community education in Kenya

Abstract Background: To assess the implementation of a pilot interprofessional train-the-trainer workshop (TTT) on sickle cell anemia (SCA) for feasibility, capacity building, and program sustainment. Methods: The TTT was used to enhance the capacity for community education about SCA in Kenya. An interprofessional team from the USA and Kenya developed the TTT and participants were recruited in Kenya. Participants evaluated the TTT at three and six months after training. Results: The TTT wa...

TRADE-OFFS IN TREE SPECIES SELECTION AND CARBON OFFSET ON FARMS ADJACENT TO KAKAMEGA-NANDI FOREST ECOSYSTEM IN KENYA

Abstract Background: Growing of trees on-farms has contributed significantly in easing pressure on the Kakamega–Nandi Forest Ecosystem. There are however concerns that Eucalyptus species is becoming the dominant tree in this landscape and may have adverse effects on the environment. Objectives: To determine the trade-offs in tree species selection and carbon offsets on farms in the margins of the Kakamega - Nandi Forest Ecosystem. Methodology: It employed a nested experimental design where...

Stocking Density Induced Stress on Plasma Cortisol and Whole Blood Glucose Concentration in Nile Tilapia Fish (Oreochromis niloticus) of Lake Victoria, Kenya

Abstract Effects of high stocking densities (HSDs) were evaluated for Nile tilapia fish (Oreochromis niloticus) under culture to determine its influence on plasma cortisol and whole blood glucose concentration. Plasma cortisol levels (ng/ml) were assayed by Enzyme-Linked Immunosorbent Assay (ELISA). Whole blood glucose levels were determined using a hand-held one touch ultraglucose meter (MD-300) and test strips. Plasma cortisol and whole blood glucose level determinations were replicated th...

Linkage between nutritional status of children 6-59 months and some socio-demographic and economic characteristics of mothers in Malava sub-county, Kakamega County

Abstract The world is currently battling the triple burden of malnutrition across all age groups including children. In Kenya, household socio-demographic and economic characteristics have been shown to contribute to malnutrition among children, but there is little known about the magnitude of their contribution at the sub-county level. This study aimed at determining the association between socio-demographic and economic characteristics of mothers and the nutritional status of their childre...

Pangenomics of the cichlid species (Oreochromis niloticus) reveals genetic admixture ancestry with potential for aquaculture improvement in Kenya

Abstract Background Nile tilapia has a variety of phenotypes suitable for aquaculture farming, yet its entire gene pool with potential for breeding climate ready strains in resource-limited settings remains scanty and poorly documented. SNP calling has become increasingly popular in molecular genetic studies due to their abundance and precision in estimating and identifying an organism’s genetic makeup. SNPs are versatile in trait-specific breeding, which, in contrast to pedigree breeding,...

Molecular Diversity of a Seemingly Altitude Restricted Ustilago kamerunensis Isolates in Kenya: A Pathogen of Napier Grass

Abstract The Central region of Kenya which is the second largest market oriented dairy zone, faces a threat in milk production. The challenge is a disease known as the napier head smut caused by Ustilago kamerunensis. This fungal microorganism is a facultative pathogen which has been reported to cause yield losses in napier grass (Pennisetum purpureum) ranging from 25% to 46% across the affected areas. Additionally, there are reports of the continual spread of the disease into neighbouring c...

Assessment of Available Phosphates and Nitrates Levels in Water and Sediments of River Isiukhu, Kenya

Abstract Surface water contamination has become one of the main environmental issues of concern and a challenge to the world population, especially in the developing world, that face potable or usable water security. In this study concentrations of available nutrients (PO4 3- and NO3 - ) in sediments and water along River Isiukhu, within Lake Victoria catchment area in Kenya are presented. Sediments and water samples were collected from 11 sampling sites along River Isiukhu. Available phosph...

Rhizobia Contribute to Salinity Tolerance in Common Beans (Phaseolus vulgaris L.)

Abstract Rhizobia are soil bacteria that induce nodule formation on leguminous plants. In the nodules, they reduce dinitrogen to ammonium that can be utilized by plants. Besides nitrogen fixation, rhizobia have other symbiotic functions in plants including phosphorus and iron mobilization and protection of the plants against various abiotic stresses including salinity. Worldwide, about 20% of cultivable and 33% of irrigation land is saline, and it is estimated that around 50% of the arable l...


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