ABSTRACT The effect of PGE^, P5P?a and PGI0 on tilu lion induced by different mechanisms was studied in the isolated rat mesenteric arteiy as described by McGregor (1965) Vasoconstriction was induced by mechanisms involving dii modes of calcium utilization viz: (i) Pharmaccnechanical pathway by low doses of the adrenergic neurotransm.itter, noradrenaline acting at - receptor; (ii) electromechanical pathway by 1.1 b potassium-and” (iip.) agents which facilitate Ca influx e.g. A23187. ! The p...
ABSTRACT The fusion between the “breakpoint cluster region” gene (BCR) and Abelson gene (ABL1) is the molecular hallmark of most cases of chronic myeloid leukaemia and some cases of acute lymphoblastic leukaemia. The objective of this study was to detect BCR-ABL1 in saliva of known CML patients collected in Oragene-RNA kit (DNA Genotek, Canada) and to see if mRNA could be preserved for a longer period in the saliva samples than in blood samples. A comparison of the BCR-ABL ratios in bloo...
ABSTRACT Globally, an estimated 3.4 billion people are at risk of malaria, including Nigerians. The current World Health Organization (WHO) Guideline for the treatment of malaria recommends the use of artemisinin combination therapy (ACT) for the treatment of uncomplicated malaria. Presently, the available formulations of ACTs are administered through the oral route. Rectal administration, which formed the basis of this work, is an alternative route of administration which overcomes the lim...
ABSTRACT Involving men in Maternal Health Care (MHC) has become important because of the realization that men‟s behaviour can significantly affect health outcomes of women and children. Male involvement in MHC is generally poor in many developing countries including Nigeria. Reasons for poor male involvement in MHC services have not been adequately documented. This study was therefore designed to determine hindrances to male involvement in MHC in Kwali Area Council, Abuja, Nigeria. A commun...
ABSTRACT The prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. This prevalence might, even, be higher in patients with human immunodeficiency virus infection. Hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled HIV infected pregnant women attending PMTCT unit of Antiretrovi...
ABSTRACT Pregelatinized Chinese yam (Dioscorea oppositifolia) starch has been evaluated as a polymer for the formulation of floating gastroretentive beads for the controlled delivery of metformin hydrochloride. Floating microbeads were prepared by the ionotropic gelation method using a blend of modified Chinese yam starch and sodium alginate at different ratios. Sodium bicarbonate was added as a gas-generating agent. The floating microbeads were characterized by SEM, DSC, FTIR analyses and...
ABSTRACT Eimeria species are important coccidian parasites worldwide causing significant economic losses from clinical and subclinical coccidiosis in poultry. Vaccines for its control in Nigeria are imported without consideration of the local species often resulting in vaccine failure. This study determined the prevalence of and characterised the Eimeria species present in Oyo and Ogun States towards an effective control and prevention of coccidiosis. A semi-structured questionnaire was admin...
ABSTRACT Schools are great platforms where children can learn hygiene skills, behaviours and practices, and when these become part of children’ daily lives, this may lead to a positive impact in families and communities at large. However, effective hygiene promotion in school can be severely affected if sanitation facilities are not adequately managed. UNICEF indicated that, despite the provision of water to schools in Ohangwena region, there are still a high proportion of schools without ...
Abstract Background: Unacceptably high maternal and perinatal mortality remains a major challenge in many low-income countries. Early detection and management of danger signs through improved access to maternal services are highly needed for better maternal and infant outcomes. The aim of this study was to test the effectiveness of an interactive mobile messaging alert system on improving knowledge on danger signs, birth preparedness, and complication readiness practices among pregnant wome...
ABSTRACT Namibia has achieved great success in the reduction of malaria case numbers from over 500 per 1000 population in 2000 to between 1 -2 per 1000 population in 2013 (MoHSS-NVDCP, 2009). The gains in the reduction of malaria case numbers have seen the country transitioning from the control phase of malaria epidemiology to the pre-elimination phase, and has subsequently adopted the goal of malaria elimination by 2020 (MoHSS-NVDCP, 2010; Pindolia et al., 2012). Since the year 2008, there ...
ABSTRACT Phenomena such as urbanisation and individual traits such as health literacy, affect people’s exposure and vulnerability to coronary artery disease risk factors. Namibia, as a developing country, is no exception. Although studies have indicated significant effects of predictor variables such as knowledge, attitudes and practices (KAP) on coronary artery diseases, none has been reported in the Namibian context. The purpose of this study was to determine and describe the knowledge, ...
Background:Cancer in children in Tanzania is a concerning health issue, yet there is a shortage of information about the experiences of the guardians of children who receive cancer treatment. Objective:To explore concerns and needs of support among guardians of children on cancer treatment in Dares Salaam, Tanzania. Method:Using a qualitative design,3 focus group discussions were held with 22 guardians of children aged 9 to 17 years. Guardians were recruited from Muhimbili National Hospital, ...
ABSTRACT In this study, the researcher explored and described the views of health care professionals who are managing children with foetal alcohol syndrome at public health facilities in the Khomas Region in Namibia. The purpose of this research project was to develop and evaluate foetal alcohol syndrome guidelines. This study was qualitative, explorative, descriptive, and contextual in nature and was conducted in four phases.
ABSTRACT Communication is the ideas and information exchanged and actions or reactions that arise from that exchange and contact. What really defines the communication is the relationship between the communicator and the recipient. Therefore, for a good nurse-patient relationship to be established, nurse patient communication must be effective. The study described in this paper was to thoroughly investigate the factors influencing communication between registered nurses and patients at Inter...
ABSTRACT Background: Globally, malnutrition is a public health problem and more than one-third of mortality among children aged below five years is attributable to malnutrition. Therefore a comprehensive nutritional assessment for early diagnosis of malnutrition and care is important. Methods: A cross-sectional study was carried out in a health facility (dispensary) among children aged below five years of age. A total of 302 children were randomly selected from twelve dispensaries in Chamwi...