Medical & Health Sciences

Research Papers/Topics in Medical & Health Sciences

Has zinc any antibiotic effect on oral bacteria? [November 8, 2017]

Search result: 13 trials were found.Clinical outcomes: The results of the mainly laboratory trials suggest that zinc has an inhibiting effect on oral bacteria.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of results and thus do not...

What are the clinical merits of chemically cured glassionomers (GIC) for placing cervical tooth restorations? [November 07, 2017]

Search result: Only trials with low-viscosity GIC were found.Clinical outcomes: The results suggest that cervical restorations placed with chemically cured GICs have good survival rates when compared to composite but are less aesthetic.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as we...

Potential of adverse effects due to aluminium, barium and strontium in GIC [November 06, 2017]

Search result: No clinical evidence concerning adverse effects of aluminium, barium or strontium released from GICs were found.Clinical outcomes: A review of the relevant laboratory literature, including a conservative calculation of any potential adverse clinical effect due to aluminium content, concludes that the amount of aluminum that could be leached into the body from glass-ionomer dental fillings is well below the permitted daily dose and almost certainly too small to ha...

What are the clinical differences between HVGIC restorations placed after handmix or capsule mix? [November 05, 2017]

Search result: Three articles could be found.Clinical outcomes: Capsule mixed HVGIC restorations appear to be superior to that of hand mixed. The quality of the existing evidence requires further assessment.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of preci...

What is the failure rate of GIC restorations placed after incomplete removal of infected carious dentine? [November 04, 2017]

Search result: Two clinical controlled trials were found.Clinical outcomes: The results suggest no difference in the failure rate of GIC restorations placed after either complete or incomplete removal of infected (soft) carious dentin.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as wel...

What is the recent evidence that merit composite resin for direct tooth restorations (as compared to amalgam as current gold standard)? [November 03, 2017]

Search result: Four clinical controlled trials were found.Clinical outcomes: The results show that composite resin performs less satisfactory when compared to amalgam. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of results a...

What effect has CPP-ACP on the plaque pH? [October 31, 2017]

Search result: One article, reporting on 2 clinical trials, was identified, concerning plaque pH-decrease after sucrose challenge: (a) comparison of CPP-ACP containing paste with no paste; (b) comparison of CPP-ACP containing paste with placebo.Clinical outcomes: The results show a significant reduction in plaque pH fall after sucrose challenge with CPP-ACP containing paste. The results of both reported trials need to be regarded with caution due to: unclear reporting of study&...

What effect has CPP-ACP on the salivary pH? [October 30, 2017]

Search result: No clinical trials or 2-arm (controlled) trials of any design (in-situ, in-vitro) could be found. Only one singlearm/longitudinal in-situ trial was identified. This trial used the test subjects as control group (without CPP-ACP).Clinical outcomes: The results of this trial showed an increase of the saliva pH in 16 out of 25 subjects after 3 weeks. A change from the initial level of pH 6.6 to the final level of around pH 7.6 was observed.[‘Preliminary Systematic Literatur...

How do both Strontium and calcium-based GIC compare clinically? [October 29, 2017]

Search result: Ten clinical trials were found and traced concerning high-viscosity conventional GIC. No trials were identified comparing strontium or calcium low-viscosity conventional GIC. All identified trials compared Fuji IX for strontium and Ketac Molar for calcium based GIC.Clinical outcomes: The overall results suggest no difference between Fuji IX and Ketac Molar in the clinical outcomes of: recurrent caries, occlusal wear and colour match. Two of the 10 trials suggest ...

Pulp response conventional GIC versus Calcium hydroxide (CaOH) cement [October 28, 2017]

Search result: Three clinical trials with a laboratory component were found.Clinical outcomes: There appears to be no difference in the pulp response between conventional GIC and CaOH-cement (CaOH is considered to be the gold standard in pulp treatment due to its high tissue supporting properties. Lack of difference between C-GIC and CaOH suggest high biocompatibility of C-GIC concerning pulp tissue).[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic ...

Survival rate of restorations with GIC cavity liners versus GIC restorations [October 27, 2017]

Search result: One clinical trial was found.Clinical outcomes: There appears to be no difference in the success rate of both types.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of results and thus do not replace the need for a&nbsp...

Survival rate of restorations with GIC cavity liners versus restorations with no-GIC liners [October 26, 2017]

Search result: Five clinical trials were found.Clinical outcomes: There appears to be no difference in the survival rate of both types of restorations. Post-operative sensitivity appears to be reduced for a short-time period after restoration placement when a GIC liner is used.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in th...

Restoration longevity of conventional high - viscosity GIC restorations versus direct composite filings [October 25, 2017]

Search result: Two clinical trials were found.Clinical outcomes: There appears to be no difference in the survival rate of both types of restorations after 2 years. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as well as the assessment of precision and internal validity of results and ...

Failure rates of direct composite versus GIC/Composite sandwich restorations [October 24, 2017]

Search result: Four clinical trials were found. The limited number of clinical trials is surprising considering that the topic of GIC/Composite sandwich restorations was very popular 20 years ago. However, the bulk of research studies appeared to be limited to a very large number of laboratory (in-vitro) trials, only. Although important to clarify material characteristics, laboratory trials are unable to provide information how well these restorations really perform in the clin...

MI Paste PLUS effect to prevent white spot lesions associated with orthodontic treatment [October 17, 2017]

Search result: Five contradicting clinical trials were found so far.Clinical outcomes: Some results show that MI Paste Plus appears more effective in reducing white spot lesions than placebo and fluoride varnish, while other results suggest that its effect appears to be equal to that of normal home care.[‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evi...


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