Medical & Health Sciences

Research Papers/Topics in Medical & Health Sciences

Atezolizumab Plus Bevacizumab Combination Therapy Compared to Sorafenib and Atezolizumab Monotherapies for Treatment of Unresectable or Metastatic Hepatocellular Carcinoma

Background/AimSorafenib has been the historical first-line treatment of choice for unresectable or metastatic hepatocellular carcinoma (HCC) since 2007. However, on May 29, 2020, FDA approved atezolizumab plus bevacizumab (AB) combination for HCC and gave it priority over sorafenib. Here, we performed a systematic review evaluating the efficacy and safety of combination immunogenic chemotherapy as first-line therapy as opposed to sorafenib (S) and atezolizumab (A) monotherapies.

Atezolizumab plus Bevacizumab vs Sorafenib or Atezolizumab Alone for Unresectable Hepatocellular Carcinoma: Systematic Review

AbstractBACKGROUNDDespite the use of the current standard therapy, the prognosis of unresectable hepatocellular carcinoma (HCC) patients is poor, with median survival times of 40 mo in intermediate HCC [Barcelona Clinic Liver Cancer (BCLC) stage B] and 6–8 mo in advanced HCC (BCLC stage C). Although patients with early-stage HCC are usually suitable for therapies with curative intention, up to 70% of patients may manifest disease relapses at 5-year surveillance. Within the past decade, ther...

Heavy Metals Contamination of an Oil Spilled Site in Niger Delta, Nigeria.

ABSTRACT Crude oil spillage is a big threat to the soil fertility. Spillage occurs due to the pipeline rupture, and traffic accidents involving tankers. An investigation was carried  to assess the effects of crude oil spillage on the physicochemical properties of soil in Nnagi-Ama, Niger Delta Nigeria. For this purpose soil samples were collected in the Nnagi-Ama, tested in a laboratory, and compared to non-polluted (control) soil sample. The pH values of the soil samples remained almost th...

Adherence to Infection Prevention Standard Precautions Among Health Care Workers in Embu Level 5 Hospital, Embu County, Kenya

ABSTRACT Standard precautions are a set of infection control practices used to prevent transmission of diseases that can be acquired by contact with blood, body fluids and non-intact skin. An effective Infection Prevention and Control (IPC) program is fundamental to quality health care. This is because it has the potential benefits of reducing disease burden on health care workers, patients, health institutions and the nation as a whole. This study was conducted with the main obj...

Bridging the Gap: An Analysis of the Food Safety and Hygienic Culture of International Fast Food Franchises and Local Fast Food Restaurants in Georgetown, Guyana

CONTENTSGENERAL INFORMATION.. 3Title of Study. 3Project Supervisor. 3Principal Investigator. 3PROJECT DEFINITION.. 4Definition of Terms. 4Project Summary. 4Research Question. 5Objectives. 5Anticipated ethical issues. 5Rationale. 6FINAL PROJECT OVERVIEW... 10Food Safety. 10The Codex Alimentarius. 11Restaurant Food Safety. 12UPDATED RESEARCH SUMMARY.. 14Participating Businesses. 14Demographics. 14Food Safe...

Investigation of Hypoglycemic Effects of Sonchus oleraceus (Moleta) in Normal Albino Rats

AbstractThe purpose of the study was to investigate the hypoglycemic effects of ethanolic and hexane extracts of Sonchus oleraceus in normal albino rats using fasting blood glucose and glucose tolerance tests. About 200 g leaves of S. oleraceus were macerated in 2 liters of hexane for two days, filtered and evaporated to dryness. Sixty albino rats were divided into six groups. Negative control group received water (5ml) and the positive control group administered by glibenclamide (5 mg/...

Assessment of the Diagnostic Performance of HIV Rapid Test Kits in Ghana

ABSTRACT Rapid diagnostic test kits are a crucial component of HIV diagnosis in resource limited settings. HIV RDTs are recommended because they are less expensive, require little expertise, require little sample volume and generate results in less than 20 minutes. The WHO, CDC, and UNAIDS recommend countries to undertake pre and post market evaluations of HIV RDTs used for HIV testing in that particular country. Little is known about post market evaluations of test used in Ghana. M...

MOTHERS’ KNOWLEDGE, ATTITUDES, BELIEFS AND PRATICES RELATED TO CHILDHOOD ANAEMIA IN THE KINTAMPO DISTRICT

ABSTRACT The prevalence of childhood anaemia remains high in the Kintampo district despite various intervention programs adopted in the past to reduce it. A cross-sectional study investigating knowledge, attitudes, beliefs and practices was carried out among seventy randomly selected mothers to find out why childhood anaemia is still a major problem in the district. Data were also collected from six traditional healers who specialize in treating childhood diseases including anaemia. ...

THE EFFECT OF HONEY, WHITE AND BROWN TABLE SUGAR ON LIPID PROFILE AND GLUCOSE LEVEL IN RATS

ABSTRACT  Background: Honey and table sugar are commonly used sweeteners by many consumers. These sweeteners are examples of disaccharide sugar which forms part of the complex macromolecule, carbohydrate. Excessive consumption of dietary sugars including table sugar and honey is associated with several metabolic abnormalities and adverse health conditions such as obesity, diabetes and cardiovascular disease. There is a general debate by many researchers and consumers that honey is ...

Condom Use By Senior High Technical School Students In Sandema, Upper East Region, Ghana

ABSTRACT For over a decade now, adolescent sexual and reproductive health and more especially condom use, has increasingly been on national agendas. In many countries especially in Sub Saharan Africa, this concern has been driven by the high prevalence of HIV and AIDS among young people. Other driving forces of comparable magnitude have been the following;  - 800 women died every day in 2013 due to pregnancy related causes. A chunk of it occurred in Sub – Saharan Africa (SSA). - O...

Implementation Challenges Of The Millennium Development Goal To Improve Maternal Health By Health Care Providers In The Tamale Metropolis Of Ghana

ABSTRACT This study examined the implementation challenges of the Millennium Development Goal to improve maternal health in the Tamale Metropolis. The study used a qualitative descriptive study. Purposive sampling was used in the selection of participants for the study. The methods for data collection included in-depth interviews, focus group discussions and a review of documents. The study participants included midwives and health managers at the facility level. The study revealed ...

Determinants Of Preterm Delivery In Ridge Regional Hospital, Greater Accra

ABSTRACT Introduction: Globally, prematurity is a major determinant of neonatal morbidity and mortality contributing about 30%-40% of neonatal mortality and 20% to 30% of infant and under-five mortality. The world‟s preterm birth rate keeps rising since the last two decades with an increase of 20% since 1990 in high-income countries. Major risk factors remain unknown. The consequences are enormous with developmental and childhood complications as well as high economic and psycho-soci...

Management Of Childhood Burns And Fall-Related Injuries In The New Juaben Municipality Of Ghana

ABSTRACT The study explored how childhood burns and falls are managed in the New Juaben Municipality in the Eastern Region of Ghana. This was against the background that childhood burns and fall-related injuries are major public health concerns that manifest in frequent hospitalization, high treatment cost, long period of recovery, pain, scar and disabilities. To address these concerns, the study set out to determine the risk factors for these childhood mishaps, to explore the treatment ...

Male Partner Involvement In Maternal Health Care In The Effutu Municipality Of The Central Region Of Ghana

ABSTRACT BACKGROUND Globally, men play critical role in women‘s ability to seek health care, including maternal health care. Male partner involvement is a key factor that cannot be ignored in the quest for improvement in maternal health. Male participation has been shown to yield substantial influence in decisions and health outcomes in several other areas of maternal health care, including antenatal, labour and delivery and postnatal care. However, male involvement has been found to ...

Factors Affecting Patient Waiting Time in the Out Patient Department in Health Care Delivery in Mokwa

ABSTRACT Patient waiting time is the time interval between when a patient presents him/herself for health care services and when he/she finally leaves the health facilities. This project work examined the causes of patient waiting time in the outpatient department at the General Hospital Mokwa. Using simple random of twenty one questionnaires to elicit information from health record officer, physician and patient attending consultative outpatient department. The results obtained indicat...


61 - 75 Of 4925 Results