ABSTRACT The aim was to investigate the effect of Sphenocentrum jollyanum (SJ) extract on alloxan-induced diabetic and hyperglycaemic rabbits. The prophylactic effect and the hypoglycaemic activity of SJ extracts were equally evaluated. Other biochemical parameters evaluated included lipid profile. The acute and chronic toxicity tests were also conducted to ascertain the plant's toxicity level. In diabetic study, alloxan diabetic rabbits were treated with graded doses of SJ at 50, 100 and 200...
ABSTRACT The commonly used antituberculosis (anti-TB) drugs, pyrazinamide (PZA), isoniazid (INH), ethambutol (EMB), and rifampicin (RMP) were administered to albino rats for the purpose of investigating the toxic consequences of combination therapies on the hematological and hepatic systems. The drugs were evaluated by simulating the normal clinical dosage. A 24-week oral administration studies of standard therapy with anti-TB drugs in albino rats without disease were carried out. The doses e...
ABSTRACT The data emerging from some of the cancer registries in sub-Saharan Africa indicate that the burden of cancer is increasing rapidly. Life style, environmental, dietary and chemical factors have all been suspected to play significant roles in the occurrence of malignancies. Rifampicin which is a first line antituberculous agent has been identified as a class three mutagen by the International Agency for Research on Cancer (IARC). Genotoxic investigation of both environmental pollutant...
ABSTRACT Diabetes Mellitus Foot Syndrome (DMFS) occurs against a background infection, neuropathy and peripheral arterial disease (PAD). Clinical assessment often under diagnoses PAD. However, the use of a hand held Doppler 10 calculate the ankle brachial index (ABI) is an inexpensive, non- invasive and quantitative method of determining the presence of PAD. A retrospective analysis of patients with DMFS who had PAD assessment with a hand held Doppler was done. Data retrieved from the doppler...
ABSTRACT Cryptorchidism is the commonest congential cause of male infertility. Male infertility is on the increase in Nigeria and current available modalities of treatment are not easily accessible but also expensive. The fertility enhancing potential of aqueous extract of the stem of Cissus populnea on the cryptorchid testes and the morphological detailing was the overall objective of this research work. One hundred and eighty male Sprague-Dawley rats were divided into twelve groups of fifte...
ABSTRACT The research investigated the state of maintenance management of public hospital buildings in South-west, Nigeria, and in the process, identified factors militating against their effective contribution to health care delivery. A total of 552 questionnaires comprising 206 for maintenance staff and 346 for users of public hospital buildings were collected and used for study. The survey covered 46 public hospitals representing 40% of the total number of existing public hospitals in Sout...
ABSTRACT Kenya has seen a drastic growth in nursing education sector recording high rates of enrolment of students to training while their performance in Nursing Council of Kenya (NCK) examination remained variable. This study investigated performance of BSc nursing students in NCK examinations by determining student characteristics, examining institutional characteristics and analyzing regulatory body characteristics in relation to performance. NCK identified it as priority area of research....
Abstract Uptake of VCT and other HIV prevention strategies among rural African women is affected by various socio-cultural and economic factors which need elucidation. Our aim was to establish the responsiveness to HIV education among rural women attending three dispensaries in Kenya. This study was designed to assess gender and psycho-social factors that influence HIV dynamics in rural Kenya. This was a cross-sectional questionnaire based study of 1347 women, conducted in October 2009. Socio...
ABSTRACT It is estimated that nearly 300,000 women die from pregnancy related complications and childbirth. Globally 34% of deliveries take place without skilled birth attendant. In Kenya more than 50% of deliveries are conducted by unskilled persons. These high indices of maternal mortality are reason for launching incentive use and digital programme in Kakamega County commonly known as “Oparanya care services”. Despite the commitment provided by the county government in resource allocat...
ABSTRACT Breast-feeding lays the foundation for healthy growth and child development. Despite the documented benefits of exclusively breast-feeding, studies have found that several predictors influence the duration of breast-feeding and few researches have assessed the predictors of exclusive breast-feeding among women informal employment in Kenya. The objective of this study was to determine the predictors of exclusive breast-feeding among mothers in formal employment attending child welfare...
ABSTRACT Since independence, the Government of Kenya has made lots of efforts to reduce maternal mortality and morbidity through some women-oriented programs. These programs are included in the marginalized groups like Ogiek in Mt. Elgon Constituency in Bungoma County. Despite this, Mt. Elgon constituency in Bungoma County still had high maternal mortality and morbidity together with low utilization of maternal health care services. Reports showed low levels of skilled delivery in Mt Elgon Co...
ABSTRACT Tuberculosis (TB) contributes 2.7% of total Disability Adjusted Life Years (DALY) in low income countries. It is also the leading infectious cause of mortality and morbidity in these countries. Kenya is one of the countries with the highest burden of tuberculosis globally. The country still has poor treatment outcomes in a significant number of patients. These poor treatment outcomes have been considerably linked to TB treatment adherence problems. The study area, Kisumu East sub-Cou...
ABSTRACT Despite the important advances in perinatal care in the past decades, asphyxia remains a severe condition leading to significant mortality and morbidity. Perinatal asphyxia has an incidence of 1 to 6 per 1,000 live full-term births, and represents the third most common cause of neonatal death (23%) after preterm birth (28%) and severe infections (26%). Each year approximately 24% of neonatal deaths occur due to birth asphyxia with an equal number of survivors with serious neurologica...
ABSTRACT Contraceptives uptake among the youth has been a sensitive and controversial issue in the society that has resulted to various social problems that include unwanted pregnancies and sexual transmitted infections among others. This calls for intervention measures that will promote contraceptive use in order to reduce unwanted pregnancies, sexual transmitted diseases and slow down the spread of HIV/AIDS among university students. The main objective of this study was to determine the uti...
Abstract Occupational Health Assessment Series (OHSAS) 18001 was recognized internationally as an auditable system to manage safety and health risks at workplaces since 1999. The purpose of the study was to assess the impact of OSHAS 18001 management system on safety performance at How Mine, a gold mining company in Zimbabwe. The objectives of the study were to analyze the occupational accidents before and after the adoption of OHSAS 18001 and to evaluate occupational injury frequency rate a...