Search result: One article, reporting on 2 clinical trials, was identified, concerning plaque pH-decrease after sucrose challenge: (a) comparison of CPP-ACP containing paste with no paste; (b) comparison of CPP-ACP containing paste with placebo. Clinical outcomes: The results show a significant reduction in plaque pH fall after sucrose challenge with CPP-ACP containing paste. The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are ...
Search result: No clinical trials or 2-arm (controlled) trials of any design (in-situ, in-vitro) could be found. Only one singlearm/longitudinal in-situ trial was identified. This trial used the test subjects as control group (without CPP-ACP). Clinical outcomes: The results of this trial showed an increase of the saliva pH in 16 out of 25 subjects after 3 weeks. A change from the initial level of pH 6.6 to the final level of around pH 7.6 was observed. The current level of clinical evidenc...
Search result: Ten clinical trials were found and traced concerning high-viscosity conventional GIC. No trials were identified comparing strontium or calcium low-viscosity conventional GIC. All identified trials compared Fuji IX for strontium and Ketac Molar for calcium based GIC. Clinical outcomes: The overall results suggest no difference between Fuji IX and Ketac Molar in the clinical outcomes of: recurrent caries, occlusal wear and colour match. Two of the 10 trials suggest a higher fa...
Search result: Three clinical trials with a laboratory component were found. Clinical outcomes: There appears to be no difference in the pulp response between conventional GIC and CaOH-cement (CaOH is considered to be the gold standard in pulp treatment due to its high tissue supporting properties. Lack of difference between C-GIC and CaOH suggest high biocompatibility of C-GIC concerning pulp tissue).The current level of clinical evidence to this topic is still limited in quantity and qua...
TABLE OF CONTENTS CONTENTS PAGE TITLE PAGE---------i DECLARATION--------ii CERTIFICATION--------iii DEDICATION--------iv ACKNOWLEDGEMENT-------v TABLE OF CONTENT-------vi LIST OF TABLES--------ix LIST OF FIGURES-------ix ABSTRACT---------x CHAPTER ONE INTRODUCTION AND LITERATURE REVIEW 1.1 TRADITIONAL MEDICINE-------1 1.2 MODERN MEDICINE--------4 1.2.1 The Role of Plants in Drug Development -----4 1.3 DESCRIPTION OF THE STUDY PLANT - -----5 1.3.1 Scientific Classification and Folkloric U...
Search result: One clinical trial was found. Clinical outcomes: There appears to be no difference in the success rate of both types.The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in ...
Search result: Five clinical trials were found. Clinical outcomes: There appears to be no difference in the survival rate of both types of restorations. Post-operative sensitivity appears to be reduced for a short-time period after restoration placement when a GIC liner is used.The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based...
Search result: Two clinical trials were found. Clinical outcomes: There appears to be no difference in the survival rate of both types of restorations after 2 years. The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing cl...
Search result: Four clinical trials were found. The limited number of clinical trials is surprising considering that the topic of GIC/Composite sandwich restorations was very popular 20 years ago. However, the bulk of research studies appeared to be limited to a very large number of laboratory (in-vitro) trials, only. Although important to clarify material characteristics, laboratory trials are unable to provide information how well these restorations really perform in the clinic, particu...
Search result: Three contradicting clinical trials were found so far. Clinical outcomes: Some results show that MI Paste Plus appears more effective in reducing white spot lesions than placebo and fluoride varnish after 3 months, while other results suggest that its effect appears to be equal to that of normal home care after 2 months. The quality of the existing evidence requires further assessment. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systemat...
Search result: 4 clinical trials were found. Clinical outcomes: The results indicate that additional selective enamel etching does not improve the clinical performance of restorations. The quality of the existing evidence requires further assessment. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evidence but are limited in the number of databases searched, as...
Search result: 15 clinical trials were found. Clinical outcomes: Minor or no improvements are reported when selective enamel etching was used. Selective enamel etching may not pose a hazard in terms of postoperative hypersensitivity. The current level of clinical evidence to this topic is still limited in quantity and quality and more trials are needed in order to confirm these results. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of...
Search result: Nine articles reporting on 4 clinical trials after different follow-up periods were found. Clinical outcomes: The results indicate no difference in retention and anatomic form of restorations after 1 – 3 years. Marginal adaptation appears to be superior for etch-and-rinse systems after 1 – 2 years and no difference was found after 3 years. Marginal discoloration is significantly more observed for (1-step) self-etch systems. Post-operative sensitivity was the same for bot...
Search result: Nine clinical studies were found. Clinical outcomes: The results suggest efficacy of resin-infiltration technique to stop caries progression and to improve aesthetic appearance of white spot lesions (WSL). However, discomfort levels appear to be higher than with other noninvasive interventions. [‘Preliminary Systematic Literature Searches’ are based on SYSTEM’s periodic systematic searches of the dental literature and provide first overviews over existing clinical evid...
Search result: As the topic of CPP-ACP is of high-priority a more intensive systematic literature search was conducted in order to produce this evidence sheet. 22 clinical studies were found. In-situ studies, as well as studies including ACP/casein materials not covered by the Recaldent technology, as included in the original systematic review, were not included. Clinical outcomes: Preventive effect: The results regarding the clinical efficacy of CPP-ACP in the prevention and treatment of...