Medical & Health Sciences

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Research Papers/Topics Medical & Health Sciences

A survey of mosquito-borne and insect- specific viruses in hospitals and livestock markets in western Kenya

Abstract: Aedes aegypti and Culex pipiens complex mosquitoes are prolific vectors of arboviruses that are a global threat to human and animal health. Increased globalization and ease of travel have facilitated the worldwide dissemination of these mosquitoes and the viruses they transmit. To assess disease risk, we determined the frequency of arboviruses in western Kenyan counties bordering an area of high arboviral activity. In addition to pathogenic viruses, insect-specific flaviviruses (IS...

Ehrlichia spp. close to Ehrlichia ruminantium, Ehrlichia canis, and “Candidatus Ehrlichia regneryi” linked to heartwater-like disease in Kenyan camels (Camelus dromedarius)

Abstract: We present findings from an outbreak of a heartwater-like disease in camels that killed at least 2000 adult animals in Kenya in 2016. Clinical signs included excitability, head pressing, aimless wandering, recumbency, and fast breathing followed by death after about 4 days. The observed morbidity in one herd was 40% with an average mortality of 7.5% in animals that received early antibiotic treatments. In untreated adults, the case fatality rate reached 100%. Gross pathology showed...

Molecular characterization of Trypanosoma vivax in tsetse flies confirms the presence of the virulent Tvv4 genotype in Kenya: Potential implications for the control of trypanosomiasis in Shim

Abstract: Trypanosoma vivax is a vector-borne protozoan parasite of livestock endemic to Africa and South America. To date, fifteen genotypes of the parasite have been described in vertebrate and insect hosts in East Africa. However, information regarding T. vivax diversity remains limited in many endemic countries in the sub-region, including Kenya. Such information could deepen insight into the local epidemiology of animal trypanosomiasis in Shimba Hills, a wildlife area in southeast Kenya...

Anaplasma and Theileria Pathogens in Cattle of Lambwe Valley, Kenya: A Case for Pro-Active Surveillance in the Wildlife-Livestock Interface

Abstract: Tick-borne pathogens (TBPs) are major constraints to livestock production and a threat to public health in Africa. This cross-sectional study investigated the risk of infection with TBPs in cattle of Lambwe Valley, Kenya. Blood samples of 680 zebu cattle from 95 herds in six geospatial clusters within 5 km of Ruma National Park were screened for bacterial and protozoan TBPs by high-resolution melting analysis and sequencing of PCR products. We detected Anaplasma bovis (17.4%), Anap...

Tick-borne pathogens, including Crimean-Congo haemorrhagic fever virus, at livestock markets and slaughterhouses in western Kenya

Abstract: Vectors of emerging infectious diseases have expanded their distributional ranges in recent decades due to increased global travel, trade connectivity and climate change. Transboundary range shifts, arising from the continuous movement of humans and livestock across borders, are of particular disease control concern. Several tick-borne diseases are known to circulate between eastern Uganda and the western counties of Kenya, with one fatal case of Crimean-Congo haemorrhagic fever (C...

Evaluating the efficacy of Mazao Tickoff (Metarhizium anisopliae ICIPE 7) in controlling natural tick infestations on cattle in coastal Kenya: Study protocol for a randomized controlled trial

Abstract: Ticks and tick-borne diseases cause substantial economic losses to the livestock industry in sub-Saharan Africa. Mazao Tickoff is a novel bioacaricide developed for tick control and is based on the entomopathogenic fungus Metarhizium anisopliae sensu lato (s.l.) isolate ICIPE 7. To date, no randomized controlled study has been undertaken to demonstrate the efficacy of this bioacaricide in reducing natural tick infestation on cattle. To this end, this field trial is designed to eval...

Survival rate, blood feeding habits and sibling species composition of Aedes simpsoni complex: Implications for arbovirus transmission risk in East Africa

Abstract: Aedes simpsoni complex has a wide distribution in Africa and comprises at least three described sub-species including the yellow fever virus (YFV) vector Ae. bromeliae. To date, the distribution and relative contributions of the sub-species and/or subpopulations including bionomic characteristics in relation to YF transmission dynamics remain poorly studied. In this study conducted in two areas with divergent ecosystems: peri-urban (coastal Rabai) and rural (Rift Valley Kerio Valle...

Examining the Intersection between Gender, Community Health Workers, and Vector Control Policies: A Text Mining Literature Review

Abstract: Gender intersects with healthcare systems; this is equally true for arboviral vector control efforts. However,there is as yet no comprehensive analysis as to how vector control is gendered. Hence, our objective is to provide thefirst thematic scoping and spatial distribution of the literature on gender, community health workers, and vector control.The authors use a systematic review approach to collect the academic literature on gender, community health workers,and vector control i...

Susceptibility of Immature Stages of the Locusts Schistocerca Gregaria and Locusta Migratoria Migratorioides to the Microsporidium Johenrea Locustae and Effects of Infection on Feeding and Fe

Abstract: Second instar nymphs of African migratory locust, Locusta migratoria migratorioides, and desert locust, Schistocerca gregaria, were tested for their susceptibility to the microsporidium pathogen Johenrea locustae (Lange et al. 1996, Journal of Invertebrate Pathology, 68, 28) in the laboratory. Spores of J. locustae were produced from live L.m. migratorioides, a conspecific to L. migratoria capito. Locusta m. migratorioides and S. gregaria were exposed to wheat seedlings sprayed wit...

Resolving taxonomic ambiguity and crypticspeciation of Hypotrigona species throughmorphometrics and DNA barcoding

Abstract: Stingless bees are important pollinators of cultivated and wild plants, contributing significantly to biodiversity and foodsecurity. Conserving pollinator plant interactions is essential to secure these ecosystems services. The use ofmorphological features in the identification of stingless bees in the genusHypotrigonais extremely difficult, due to manysimilarities among species resulting in taxonomic ambiguity. Here, we apply both traditional morphometrics and DNAbarcoding as ompl...

The effects of crude propolis, its volatiles andethanolic extracts on the ecto-parasitic mite,Varroa destructorand health of the Africansavannah honey bee,Apis mellifera scutellata

Abstract: Propolis is a hive product composed of biologically active plant resins, and has been shown toenhance individual honey bee (Apis melliferaL.) health. Propolis has also been demonstratedto mitigate, in part, the negative effects caused by the ecto-parasitic miteVarroa destructorand its associated viruses on the health of managed European honey bee colonies.However, its effect on the health status of African honey bees remains largely unknown.Here, we found that the African savannah ...

Can encroached rangelands enhance carbon sequestration in the African Savannah?

Abstract: Climate change and bush encroachment pose huge challenges to rangeland management in Namibia. These challenges require a holistic management approach that ensures consistent and optimum forage productivity and sustainability. Mechanical and chemical control methods are the most used techniques in controlling woody encroaching species to improve pastoral properties in the Namibian savannas. However, there is very little information regarding the management options that concurrently ...

The effect of climate variability in the efficacy of the entomopathogenic fungus Metarhizium acridum against the desert locust Schistocerca gregaria

Abstract: Despite substantial efforts to control locusts they remain periodically a major burden in Africa, causing severe yield loss and hence loss of food and income. Distribution maps indicating the value of the basic reproduction number R0 was used to identify areas where an insect pest can be controlled by a natural enemy. A dynamic process-based mathematical model integrating essential features of a natural enemy and its interaction with the pest is used to generate R0 risk maps for in...

Developing low-cost house floors to control tungiasis in Kenya – a feasibility study

Abstract: Context Tungiasis is a neglected tropical skin disease endemic in resource-poor communities. It is caused by the penetration of the female sand flea, Tunga penetrans, into the skin causing immense pain, itching, difficulty walking, sleeping and concentrating on school or work. Infection is associated with living in a house with unsealed earthen house floors. Methods This feasibility study used a community-based co-creation approach to develop and test simple, locally appropriate, a...

Socioeconomic burden of trypanosomiasis: Evidence from crop and livestock production in Ethiopia

Abstract: This paper estimates the impact of trypanosomiasis on crop-livestock production, economic loss and poverty in Ethiopia. We use unique panel data to estimate how the disease affects livestock deaths, production costs and crop production. We then use these estimates to evaluate the disease's total economic loss and its implications on poverty in the study districts and the country. Estimates of the fixed effect regression models indicate that trypanosomiasis increases the value of li...


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